2. Search Result
Search Result
Results for "

corneal

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

4

Biochemical Assay Reagents

4

Peptides

1

Inhibitory Antibodies

5

Natural
Products

1

Isotope-Labeled Compounds

1

Click Chemistry

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-102032
    Butyryltimolol

    		Adrenergic Receptor Endocrinology
    Butyryltimolol, an effective precursor of Timolol, improves the corneal penetration of Timolol . Butyryltimolol is a β-adrenergic blocker .
    Butyryltimolol
  • HY-102032A
    (RS)-Butyryltimolol

    		Adrenergic Receptor Others
    (RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol, an effective proagent of Timolol, improves the corneal penetration of Timolol . Butyryltimolol is a β-adrenergic blocker .
    (RS)-Butyryltimolol
  • HY-111406
    Omidenepag isopropyl

    DE-117

    		 Prostaglandin Receptor Cardiovascular Disease Inflammation/Immunology
    Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration, and Omidenepag is a highly selective EP2 receptor agonist. Omidenepag isopropyl shows only weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as an intraocular pressure (IOP)-lowering agent.
    Omidenepag isopropyl
  • HY-17639
    Navamepent

    RX-10045

    		 Biochemical Assay Reagents Inflammation/Immunology
    Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Navamepent
  • HY-P99578
    Tanfanercept

    HL036337; HBM9036

    		 TNF Receptor Inflammation/Immunology
    Tanfanercept (HL036337) is an TNF-α receptor fusion protein that targets TNF-α. Tanfanercept is effective in ameliorating corneal erosions in a dry eye (DE) mouse model .
    Tanfanercept
  • HY-135627
    JBP485

    cyclo(L-Hyp-L-Ser)

    		 Endogenous Metabolite Others
    JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases .
    JBP485
  • HY-123195
    CK-119

    		Interleukin Related Cancer
    CK-119 is a potent interleukin-1 blocker. CK-119 inhibits the cell growth of fibroblast-like corneal and conjunctival cells, mainly by inhibiting DNA and RNA syntheses .
    CK-119
  • HY-P10797
    TAT-N24

    		NF-κB HIF/HIF Prolyl-Hydroxylase VEGFR TNF Receptor Interleukin Related Cardiovascular Disease Inflammation/Immunology
    TAT-N24 is a cell-permeable TAT peptide as a p55PIK signaling inhibitor. TAT-N24 is effective for corneal neovascularization (CNV) and ocular inflammation by inhibiting the HIF-1α/NF-κB signaling pathway in corneal suture (CS). TAT-N24 also inhibits corneal neovascularization .
    TAT-N24
  • HY-131420
    12-Methyltridecanoic acid

    Aseanostatin P1; Isotetradecanoic acid

    		 Biochemical Assay Reagents Others
    12-Methyltridecanoic acid is a methylated fatty acid that has been found in milk. 12-Methyltridecanoic acid (200 μM) reduces angiogenesis and corneal opacity in alkaline or Pseudomonas aeruginosa-induced ocular mouse models.
    12-Methyltridecanoic acid
  • HY-B0964A
    Riboflavin phosphate

    Riboflavine phosphate; Riboflavin 5'-phosphate; Riboflavine 5'-phosphate

    		 Endogenous Metabolite Metabolic Disease
    Riboflavine phosphate is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate is a very effective NAD +-recycling agent .
    Riboflavin phosphate
  • HY-B0964
    Riboflavin phosphate sodium

    Riboflavine phosphate sodium; Riboflavin 5'-phosphate sodium; Riboflavine 5'-phosphate sodium

    		 Endogenous Metabolite Others
    Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium is a very effective NAD +-recycling agent .
    Riboflavin phosphate sodium
  • HY-13813
    Blebbistatin
    Maximum Cited Publications
    22 Publications Verification

    		 Myosin Others
    Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration .
    Blebbistatin
  • HY-W013713
    Riboflavin phosphate sodium hydrate

    Riboflavine phosphate sodium hydrate; Riboflavin 5'-phosphate sodium hydrate; Riboflavine 5'-phosphate sodium hydrate

    		 Endogenous Metabolite Others
    Riboflavine phosphate sodium hydrate (Riboflavine 5'-phosphate sodium hydrate) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavine phosphate sodium hydrate can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium hydrate is a very effective NAD +-recycling agent .
    Riboflavin phosphate sodium hydrate
  • HY-162171
    Antibacterial agent 179

    		Bacterial Infection
    Antibacterial agent 179 (Compound 23) is a potent antibacterial agent, which effectively kills both Gram-negative and Gram-positive bacteria. Antibacterial agent 179 shows potent in vivo antibacterial efficacy in murine corneal infection models caused by Staphylococcus aureus or Pseudomonas aeruginosa .
    Antibacterial agent 179
  • HY-B0964R
    Riboflavin phosphate (sodium) (Standard)

    		Endogenous Metabolite Others
    Riboflavin phosphate (sodium) (Standard) is the analytical standard of Riboflavin phosphate (sodium). This product is intended for research and analytical applications. Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium is a very effective NAD+-recycling agent .
    Riboflavin phosphate (sodium) (Standard)
  • HY-17495
    Carteolol

    OPC-1085

    		 Adrenergic Receptor Caspase Bcl-2 Family Neurological Disease
    Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research .
    Carteolol
  • HY-129934
    Latanoprost ethyl amide

    Lat-NEt

    		 Prostaglandin Receptor Endocrinology
    Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
    Latanoprost ethyl amide
  • HY-P1194
    Spantide I

    		Neurokinin Receptor Inflammation/Immunology
    Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .
    Spantide I
  • HY-W013713R
    Riboflavin phosphate sodium hydrate (Standard)

    		Endogenous Metabolite Others
    Riboflavin phosphate (sodium hydrate) (Standard) is the analytical standard of Riboflavin phosphate (sodium hydrate). This product is intended for research and analytical applications. Riboflavine phosphate sodium hydrate (Riboflavine 5'-phosphate sodium hydrate) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavine phosphate sodium hydrate can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium hydrate is a very effective NAD+-recycling agent .
    Riboflavin phosphate sodium hydrate (Standard)
  • HY-P1194A
    Spantide I TFA

    		Neurokinin Receptor Inflammation/Immunology
    Spantide I TFA, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .
    Spantide I TFA
  • HY-131617
    Prostaglandin F2α 1,11-lactone

    PGF2α 1,11-lactone

    		 Prostaglandin Receptor Others
    Prostaglandin F2α 1,11-lactone is a prostaglandin. Prostaglandin F2α 1,11-lactone is absorbed by the eye. Prostaglandin F2α 1, 11-Lactone has metabolic stability on the corneal surface and conjunctiva. Prostaglandin F2α 1,11-lactone can be used in the treatment of glaucoma .
    Prostaglandin F2α 1,11-lactone
  • HY-124404
    12(R)-HETE

    		Na+/K+ ATPase Aryl Hydrocarbon Receptor Others Inflammation/Immunology
    12(R)-HETE is a metabolite of Arachidonic acid, AA (HY-109590) and can be found in skin from psoriatic lesions. 12(R)-HETE induces lymphocytes chemotaxis, stimulates calcium mobilization and chemotaxis in neutrophils via the BLT1 receptor, activates the aryl hydrocarbon receptor, and inhibits Na+/K+ ATPase activity in the corneal epithelium .
    12(R)-HETE
  • HY-142980
    Dioleoylphosphatidylglycerol

    DOPG

    		 Liposome Inflammation/Immunology
    Dioleoylphosphatidylglycerol (DOPG) is a naturally occurring phospholipid that can be produced by the combined action of aquaporin 3 (AQP3) and phospholipase D2 (PLD2). Dioleoylphosphatidylglycerol inhibits macrophage inflammatory mediator production in response to heat shock protein B4 (HSPB4) activation of toll-like receptor 2 (TLR2) .
    Dioleoylphosphatidylglycerol
  • HY-123639
    LM-4108

    N-(2-Phenylethyl)-indomethacin amide

    		 COX Inflammation/Immunology Cancer
    LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively .
    LM-4108
  • HY-129934S
    Latanoprost ethyl amide-d4

    Lat-NEt-d4

    		 Isotope-Labeled Compounds Prostaglandin Receptor Endocrinology
    Latanoprost ethyl amide-d4 (Lat-NEt-d4) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .
    Latanoprost ethyl amide-d4
  • HY-17642
    Omidenepag
    1 Publications Verification

    UR-7276

    		 Prostaglandin Receptor Endocrinology
    Omidenepag (UR-7276), a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM. Omidenepag shows binding affinities (IC50) 10 nM for h-EP2 .
    Omidenepag
  • HY-111751
    JNJ-61432059
    1 Publications Verification

    		 iGluR Neurological Disease
    JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models .
    JNJ-61432059
  • HY-164525
    SD-7300

    SC-81490; PF-02881307

    		 MMP Cancer
    SD-7300 (SC-81490) is an orally active inhibitor of MMP-2, MMP-9, and MMP-13 with Ki values ??of 0.03, 0.01, and 0.03 nM, respectively. SD-7300 can reduce the degradation of extracellular matrix by tumor cells, thereby inhibiting the invasion and metastasis of tumor cells. In addition, SD-7300 is also a dose-dependent inhibitor of mouse corneal angiogenesis and an inhibitor of interleukin-1-induced bovine cartilage degradation. SD-7300 can be used in breast cancer research .
    SD-7300
  • HY-10801
    CAY10650
    5+ Cited Publications

    		 Phospholipase Inflammation/Immunology
    CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion .
    CAY10650
  • HY-116116
    Tafetinib

    SIM010603

    		 c-Kit RET VEGFR Cancer
    Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC50values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis .
    Tafetinib
  • HY-157666
    13:0 PC

    PC(13:0/13:0)

    		 Endogenous Metabolite Others
    13:0 PC (PC(13:0/13:0)), also known as ditridecanoyl phosphatidyl choline (DTPC), is a phospholipid characterized by its unique structure that includes a polar head with a positively charged quaternary amine and a negatively charged phosphate, along with two non-polar fatty acid tails. This composition allows 13:0 PC to function effectively as a surfactant in mucus, while its amphiphilic nature makes it an essential component of cell membranes, particularly in endothelial cells, corneal epithelial cells, and fibroblasts. The liver synthesizes 13:0 PC, and it is also found in dietary sources such as eggs and soybeans. In addition, Avanti offers a diverse range of phosphatidylcholine products, including 13:0 PC, which are meticulously purified by HPLC to maintain their stability against oxidation and hydrolysis.
    13:0 PC

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: