decay

By Targets:	Apoptosis (1) Bacterial (1) CFTR (1) Cholinesterase (ChE) (1) DNA Stain (1) Eukaryotic Initiation Factor (eIF) (1) Fungal (1) GABA Receptor (2) IRE1 (3) Sodium Channel (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (1) Neurological Disease (4)
Oligonucleotides:	Antisense Oligonucleotides (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W012642

2-Aminopurine	DNA Stain	Others
2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics .

HY-161111

KVS0001	Others	Cancer
KVS0001 is a potent inhibitor of SMG1 and nonsense mediated decay (NMD) that has anti-tumor activity .

HY-111374

NMDI14 3 Publications Verification	Others	Cancer
NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD.

HY-B2053

Tolclofos-methyl	Bacterial	Infection
Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is used as a see treatment for protection against soil-borne and seed borne fungal pathogens that caused seed decay and seedling blights.

HY-153475

IRE1α kinase-IN-9	IRE1	Cancer
IRE1α kinase-IN-9 (compound 2) is a potent IRE-1α inhibitor，exhibits an average IC₅₀ value of <0.1 μM. IRE1α kinase-IN-9 can be used for research in diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) .

HY-153474

IRE1α kinase-IN-8	IRE1	Others
IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor. IRE1α kinase-IN-8 can be used for research in diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) .

HY-167695

Propiosyringone	Others	Others
Propiosyringone is derived from the breakdown of Eucalyptus globulus wood by wood-decaying fungi.

HY-118202

(-)-Gallopamil (-)-Methoxyverapamil	Others	Cardiovascular Disease
(-)-Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil also accelerates the voltage-dependent phase of I_Ca decay (as well as the voltage-dependent decay of Ba ²⁺ currents). (-)-Gallopamil is promising for research of antiarrhythmics .

HY-118202A

(-)-Gallopamil hydrochloride (-)-Methoxyverapamil hydrochloride	Others	Cardiovascular Disease
(-)-Gallopamil (hydrochloride) exerts a selective modulation of the fast voltage-dependent inactivation. (-)-Gallopamil (hydrochloride) inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation). (-)-Gallopamil (hydrochloride) also accelerates the voltage-dependent phase of I_Ca decay (as well as the voltage-dependent decay of Ba ²⁺ currents). (-)-Gallopamil (hydrochloride) is promising for research of antiarrhythmics .

HY-103501

SB-205384	GABA Receptor	Neurological Disease
SB-205384 is a GABAA receptor modulator. The primary effect of SB-205384 on GABAA-activated currents is a prolonged response decay half-life upon removal of the agonist .

HY-138100

Hyalodendrin (+)-Hyalodendrin	Fungal	Infection
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-100686

U93631	GABA Receptor	Neurological Disease
U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.

HY-145422

KIRA9	IRE1 Apoptosis	Others
KIRA9 is a potent IRE1 inhibitor (IC₅₀=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis .

HY-126429

Nav1.1 activator 1	Sodium Channel	Neurological Disease
Nav1.1 activator 1 (compound 4), a highly potent Na_v1.1 activator with BBB penetration, increases decay time constant τ of Na_v1.1 currents at 0.03 μM along with significant selectivity against Na_v1.2, Na_v1.5, and Na_v1.6 .

HY-101513

eIF4A3-IN-1 3 Publications Verification	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC₅₀=0.26 μM; K_d=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD .

HY-150090

SRI-41315 1 Publications Verification	CFTR	Inflammation/Immunology
SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity .

HY-121143

Bis-Q	Cholinesterase (ChE)	Neurological Disease
Bis-Q is an acetylcholine (ACh) agonist that targets voltage-clamped muscle fibers of the fish Xenomystus nigris. Bis-Q exists in two forms: cis-Bis-Q (non-agonist) and trans-Bis-Q (agonist). Photoisomerization converts cis-Bis-Q to trans-Bis-Q, which induces agonist-induced currents. Channels activated by trans-Bis-Q and ACh have similar conductances and open times. Flashes increase the ratio of trans-Bis-Q to cis-Bis-Q until light equilibrium is reached. Further flashes transiently increase agonist-induced currents, indicating binding of trans-Bis-Q to desensitized receptors. Higher concentrations of cis-Bis-Q produce larger agonist-induced currents that decay exponentially. .

Cat. No.	Product Name	Type

HY-W012642

2-Aminopurine	Fluorescent Dyes/Probes
2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics .

Cat. No.	Product Name	Target	Research Area

HY-P3983

[Cys(Bzl)84] CD (81-92)	Peptides	Others
[Cys(Bzl)84] CD (81-92) is an acidic peptide. [Cys(Bzl)84] CD (81-92) can be sequencing by negative ion postsource decay (PSD) spectra .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-138100

Hyalodendrin (+)-Hyalodendrin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

Species:	Human (2) Mouse (1) Rat (1)
Tag:	His (2) Fc (2)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P72721

	CD55/DAF Protein, Human (HEK293, His) Complement decay-Accelerating factor; CD55; CR; DAF	Human	HEK293
	The CD55/DAF protein is critical in the immune system, recognizing C4b and C3b fragments, interfering with their enzymatic conversion and preventing the formation of complement cascade amplifying convertase. This regulatory mechanism alleviates complement-induced damage by inhibiting complement activation. CD55/DAF Protein, Human (HEK293, His) is the recombinant human-derived CD55/DAF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD55/DAF Protein, Human (HEK293, His) is 319 a.a., with molecular weight of 50-75 kDa.

HY-P75394

	CD55/DAF Protein, Human (HEK293, hFc) Complement decay-Accelerating factor; CD55; CR; DAF	Human	HEK293
	The CD55/DAF protein is critical in the immune system, recognizing C4b and C3b fragments, interfering with their enzymatic conversion and preventing the formation of complement cascade amplifying convertase. This regulatory mechanism alleviates complement-induced damage by inhibiting complement activation. CD55/DAF Protein, Human (HEK293, hFc) is the recombinant human-derived CD55/DAF protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD55/DAF Protein, Human (HEK293, hFc) is 319 a.a., with molecular weight of 95-105 kDa.

HY-P75655

	CD55/DAF Protein, Mouse (HEK293, His) Complement decay-Accelerating factor; CD55; CR; DAF	Mouse	HEK293
	The CD55/DAF protein is critical in the immune system and recognizes C4b and C3b fragments. It interacts with cell-associated C4b and C3b, interfering with their enzymatic conversion and preventing the formation of complement cascade amplifying convertase. CD55/DAF Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD55/DAF protein, expressed by HEK293 , with C-His labeled tag.

HY-P76241

	CD55/DAF Protein, Rat (HEK293, Fc) Complement decay-Accelerating factor; CD55; CR; DAF	Rat	HEK293
	The CD55/DAF protein lacks conserved residues critical for feature annotation propagation and exhibits unique qualities that have prompted exploration of its structural and functional implications. This unique property suggests underlying nuances in molecular interactions and regulatory mechanisms. CD55/DAF Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD55/DAF protein, expressed by HEK293 , with C-hFc labeled tag.

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HY-P82695

	CD55 Antibody (YA2440) CD55; CR; DAF; Complement decay-accelerating factor; CD55	WB	Human
	CD55 Antibody (YA2440) is a biotin-conjugated non-conjugated IgG antibody, targeting CD55, with a predicted molecular weight of 41 kDa (observed band size: 78 kDa). CD55 Antibody (YA2440) can be used for WB experiment in human background.

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Cat. No.	Product Name		Classification

HY-158830

MDM4-targeting ASO sodium		Antisense Oligonucleotides
MDM4-targeting ASO sodium is a 25mer antisense oligonucleotide targeting?MDM4. MDM4-targeting ASO sodium induced exon 6 skipping, leading to nonsense-mediated decay of the mRNA transcript that excludes exon-6. In multiple human melanoma cell lines and in melanoma patient-derived xenograft (PDX) mouse models, MDM4-targeting ASO-mediated skipping of exon 6 decreased MDM4 abundance, inhibited melanoma growth, and enhanced sensitivity to MAPK-targeting therapeutics.

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