diaryl

By Targets:	Apoptosis (3) Autophagy (1) Biochemical Assay Reagents (1) COX (1) GABA Receptor (1) HSP (1) LIM Kinase (LIMK) (1) Liposome (1) p38 MAPK (1) PDK-1 (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Pegylated Lipids (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119412

Biliatresone	Reactive Oxygen Species	Metabolic Disease
Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model .

HY-110042

CCT018159	HSP Apoptosis	Cancer
CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC₅₀s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis .

HY-135843

TH-263	LIM Kinase (LIMK)	Cancer
TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257 .

HY-11087

SD 0006 SD-06	p38 MAPK Autophagy	Inflammation/Immunology
SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC₅₀ of 110 nM for p38α .

HY-103387

DuP-697	COX Apoptosis	Inflammation/Immunology Cancer
DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active COX-2 inhibitor (IC₅₀ of 10 nM and 800 nM for human COX-2 and COX-1, respectively). DuP-697 exerts antiproliferative (IC₅₀ of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects .

HY-100982

(E)-4-Hydroxycrotonic acid trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA	GABA Receptor	Neurological Disease
(E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a k_i value of 1.1 μM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with k_i values ranging from 0.023 to 0.075 μM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models .

HY-114645

PDK1-IN-RS2	PDK-1	Cancer
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a K_d of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1 .

HY-121856

Flumizole	Others	Inflammation/Immunology
Flumizole, a derivative of substituted 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles, was synthesized and evaluated for its immunoregulatory and anti-inflammatory properties in animal models such as rat adjuvant-induced arthritis and mouse oxazolone-induced contact sensitivity assays. This compound class combines structural elements from flumizole and levamisole, aiming to enhance therapeutic efficacy. Symmetrically substituted 5,6-diaryl compounds with specific alkyl heteroatom or halogen substitutions showed optimal potency in the arthritis model. However, variations in activity were less consistent in the contact sensitivity assay. Flumizole and related compounds demonstrate potential as dual-action agents, targeting inflammation and immune modulation, offering promise for therapeutic development in immune-related disorders .

HY-121451

Dibenzyl phthalate	Biochemical Assay Reagents	Others
Dibenzyl phthalate, a diaryl phthalate, is extensively used as a plasticizer to modify the properties of the synthetic resin substrates, resulting in the improvement of flexibility and durability of the end products. Dibenzyl phthalate has estrogen agonist/antagonist properties .

HY-155907

DSPE-PEG-Amine, MW 5000 ammonium DSPE-PEG-NH2, MW 5000 ammonium	Liposome	Others
DSPE-PEG-Amine, MW 5000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. DSPE-PEG-Amine, MW 5000 (ammonium) amino group can be converted to aromatic aldehydes that react with acetone-protected aromatic hydrazides on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes produce liposome-Bah-BCA conjugates by forming diaryl hydrazone (BAH) with target enzyme molecules. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.

HY-151620

Antitumor agent-80	Apoptosis	Cancer
Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells .

Cat. No.	Product Name	Type

HY-155907

DSPE-PEG-Amine, MW 5000 ammonium DSPE-PEG-NH2, MW 5000 ammonium	Drug Delivery
DSPE-PEG-Amine, MW 5000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. DSPE-PEG-Amine, MW 5000 (ammonium) amino group can be converted to aromatic aldehydes that react with acetone-protected aromatic hydrazides on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes produce liposome-Bah-BCA conjugates by forming diaryl hydrazone (BAH) with target enzyme molecules. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.

DSPE-PEG-Amine, MW 5000 ammonium

DSPE-PEG-NH2, MW 5000 ammonium

Drug Delivery

DSPE-PEG-Amine, MW 5000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. DSPE-PEG-Amine, MW 5000 (ammonium) amino group can be converted to aromatic aldehydes that react with acetone-protected aromatic hydrazides on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes produce liposome-Bah-BCA conjugates by forming diaryl hydrazone (BAH) with target enzyme molecules. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119412

Biliatresone	Structural Classification Flavonoids other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Isoflavones	Reactive Oxygen Species
Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model .

Cat. No.	Product Name		Classification

HY-155907

DSPE-PEG-Amine, MW 5000 ammonium DSPE-PEG-NH2, MW 5000 ammonium		Pegylated Lipids
DSPE-PEG-Amine, MW 5000 (ammonium) is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. DSPE-PEG-Amine, MW 5000 (ammonium) amino group can be converted to aromatic aldehydes that react with acetone-protected aromatic hydrazides on the surface of the bovine carbonic anhydrase (BCA) molecule. Liposomes produce liposome-Bah-BCA conjugates by forming diaryl hydrazone (BAH) with target enzyme molecules. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Oligonucleotides

Name
Email *

	Sorry, but the email address you supplied was invalid.

diaryl

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Oligonucleotides

Natural
Products