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Results for "

endothelin receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endothelin Receptor (68) Angiotensin Receptor (3) Antibiotic (4) Apoptosis (5) Bacterial (4) CGRP Receptor (1) Drug Metabolite (1) Estrogen Receptor/ERR (3) HIV (1) Isotope-Labeled Compounds (2) Vasopressin Receptor (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (66) Endocrinology (30) Infection (7) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (9)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Darusentan Lu-135252	Endothelin Receptor	Cardiovascular Disease Endocrinology
Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) *receptor* antagonist, which binds with a K_i of 1.4 nM to the ET-A receptor and a K_i of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors . Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K_i of 13 nM .

BMS 182874	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
BMS 182874 is an orallyactive, highly selective **endothelin receptor (ET_A** receptor) antagonist, with IC₅₀ value of 0.150 μM, K_i of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research .

BQ-3020 ammonium	Endothelin Receptor	Cardiovascular Disease
BQ-3020 ammonium is a selective **endothelin receptor** (ET_B receptor) agonist. BQ-3020 ammonium inhibits [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 ammonium elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 ammonium makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research . .

Sulfisoxazole 2 Publications Verification Sulfafurazole	Endothelin Receptor Bacterial Antibiotic	Infection Endocrinology Cancer
Sulfisoxazole (Sulfafurazole) is an orally active **endothelin receptor antagonist with IC₅₀** values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A .

Patecibart	Endothelin Receptor	Cardiovascular Disease
Patecibart is a humanized immunoglobulin G4-kappa, anti-EDNRA monoclonal antibody. Patecibart is an **endothelin receptor** antagonist .

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a **endothelin receptor agonist and has an ET_A/ET_B** selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

Sarafotoxin S6a TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a **endothelin receptor agonist and has an ET_A/ET_B** selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

BQ-3020	Endothelin Receptor	Cardiovascular Disease
BQ-3020 is a selective **endothelin receptor** (ET_B receptor) agonist that displaces [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research ¹ ².

Sulfisoxazole diethanolamine Sulfafurazole diethanolamine	Endothelin Receptor Antibiotic Bacterial	Infection Endocrinology Cancer
Sulfisoxazole (Sulfafurazole) diethanolamine is an **endothelin receptor antagonist with IC₅₀** values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A .

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of **Endothelin Receptor**. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

TBC3711	Endothelin Receptor	Endocrinology
TBC3711 is a **endothelin receptor** modulator, used for the research of endothelin-mediated disorders.

Sulfisoxazole (Standard)	Endothelin Receptor Bacterial Antibiotic	Infection Endocrinology Cancer
Sulfisoxazole (Standard) is the analytical standard of Sulfisoxazole. This product is intended for research and analytical applications. Sulfisoxazole (Sulfafurazole) is an orally active **endothelin receptor antagonist with IC₅₀** values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A .

Edonentan BMS 207940	Endothelin Receptor	Cardiovascular Disease
Edonentan (BMS 207940) is an antagonist for endothelin receptor (ET_A receptor), with a K_i of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model .

ABT-546 A-216546	Endothelin Receptor	Cardiovascular Disease Endocrinology
ABT-546 (A-216546) is a potent, highly selective and active **endothelin ET_A receptor antagonist with a K_i** of 0.46 nM for [ ¹²⁵I]endothelin-1 binding to cloned *human endothelin* ET_A*. ABT-546 is >25,000-fold more selective for the ET_A receptor* than for the ET_B receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC₅₀ of 0.59 nM and 3 nM, respectively .

Endothelin 1 (swine, human) 5+ Cited Publications	Endothelin Receptor	Inflammation/Immunology Endocrinology
Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

Endothelin 1 (swine, human) (TFA) 5+ Cited Publications	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

Endothelin 1 (swine, human), Alexa Fluor 488-labeled	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

Bosentan Maximum Cited Publications 23 Publications Verification	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

Bosentan hydrate Maximum Cited Publications 23 Publications Verification	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

Nebentan potassium YM598	Endothelin Receptor	Cardiovascular Disease Inflammation/Immunology
Nebentan potassium (YM598) is a potent, selective and orally active non-peptide **endothelin ET_A receptor** antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [ ¹²⁵I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively . YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo .

Nebentan YM598 free base	Endothelin Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
Nebentan (YM598 free base) is a potent, selective and orally active non-peptide **endothelin ET_A receptor** antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [ ¹²⁵I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively . YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo .

PD 142893	Endothelin Receptor	Cardiovascular Disease
PD 142893 is a **endothelin-B receptor** antagonist .

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification endothelin 3 (Rat,Human) (TFA)	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

Atrasentan sodium	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Atrasentan sodium is an **endothelin receptor antagonist with IC₅₀** of 0.0551 nM for ET_A .

Bosentan-d4	Endothelin Receptor	Cardiovascular Disease Endocrinology
Bosentan-d4 is the deuterium labeled Bosentan. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

Avosentan Ro 67-0565; SPP-301	Endothelin Receptor	Cardiovascular Disease Endocrinology
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.

IRL 1038	Endothelin Receptor	Neurological Disease
IRL 1038 is an **endothelin B receptor selective antagonist with a K_i** of 6-11 nM .

BQ-123 2 Publications Verification	Endothelin Receptor	Cardiovascular Disease
BQ-123 is a potent and selective **endothelin A (ETA) receptor antagonist with an IC₅₀ of 7.3 nM and a K_i** of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .

ATZ-1993	Endothelin Receptor	Cardiovascular Disease
ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pK_i values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery .

Sitaxsentan IPI 1040; TBC-11251	Endothelin Receptor	Cardiovascular Disease Endocrinology
Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist.

PD-156707	Endothelin Receptor	Cardiovascular Disease
PD-156707 is an orally active, nonpeptide and selective *Endothelin-A* receptor antagonist .

BQ-123 TFA	Endothelin Receptor	Cardiovascular Disease
BQ-123 TFA is a potent and selective **endothelin A (ETA) receptor antagonist with an IC₅₀ of 7.3 nM and a K_i** of 25 nM. BQ-123 TFA inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .

Bosentan (Standard)	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan (Standard) is the analytical standard of Bosentan. This product is intended for research and analytical applications. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

Bosentan hydrate (Standard)	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan (hydrate) (Standard) is the analytical standard of Bosentan (hydrate). This product is intended for research and analytical applications. Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.

FR139317 PD 147953	Endothelin Receptor	Cardiovascular Disease
FR139317 (PD 147953) is a selective ET_A receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs .

Sitaxsentan sodium 1 Publications Verification IPI 1040 sodium; TBC11251 sodium	Endothelin Receptor	Cardiovascular Disease Endocrinology
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of **endothelin A receptors**.

Atrasentan 5 Publications Verification ABT-627; (+)-A 127722; A-147627	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Atrasentan (ABT-627) is an **endothelin receptor antagonist with IC₅₀** of 0.0551 nM for ET_A .

Enrasentan SB 217242	Endothelin Receptor	Cardiovascular Disease
Enrasentan (SB 217242) is an **endothelin (ET) receptor** antagonist. Enrasentan has antihypertensive effects .

Atrasentan hydrochloride 5 Publications Verification ABT-627 hydrochloride; (+)-A 127722 hydrochloride; A-147627 hydrochloride	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective **endothelin A receptor antagonist with an IC₅₀** of 0.0551 nM for ET_A .

IRL-1620	Endothelin Receptor	Neurological Disease Endocrinology
IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM.

Tezosentan RO 610612	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA₂s of 9.5, 7.7 for ET_A and ET_B receptors, respectively.

IRL-1620 TFA 1 Publications Verification	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology
IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM .

SB234551	Endothelin Receptor	Neurological Disease
SB234551 is a selective endothelin ETA receptor antagonist. SB234551 can be used in the study of stroke model .

A-127722	Endothelin Receptor	Cardiovascular Disease
A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ET_A selective endothelin receptor (ET receptor) antagonist with IC₅₀ value of 0.36 nM .

WS009A	Endothelin Receptor	Cardiovascular Disease
WS009A is an antagonist for **endothelin receptor** (ET Receptor) with IC₅₀ of 5.8 and 6.9 μM for ET-1 receptor and ET-2 receptor. WS009A can be used in research of cardiovascular diseases .

Sparsentan RE-021; DARA-a	Angiotensin Receptor Endothelin Receptor	Cardiovascular Disease Endocrinology
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with K_is of 0.8 and 9.3 nM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P1016B

BQ-3020 ammonium	Endothelin Receptor	Cardiovascular Disease
BQ-3020 ammonium is a selective **endothelin receptor** (ET_B receptor) agonist. BQ-3020 ammonium inhibits [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 ammonium elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 ammonium makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research . .

HY-P0207A

Endothelin-2 (49-69), human TFA endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA	Peptides	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P0202

Endothelin 1 (swine, human) Maximum Cited Publications 6 Publications Verification	Endothelin Receptor	Inflammation/Immunology Endocrinology
Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-P0202A

Endothelin 1 (swine, human) (TFA) Maximum Cited Publications 6 Publications Verification	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a **endothelin receptor agonist and has an ET_A/ET_B** selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P1112A

Sarafotoxin S6a TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a **endothelin receptor agonist and has an ET_A/ET_B** selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-105183

PD 145065	Peptides	Others
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC₅₀ value of 4 nM for the ET_A receptor for rabbit renal artery vascular smooth muscle cells .

HY-P1016

BQ-3020	Endothelin Receptor	Cardiovascular Disease
BQ-3020 is a selective **endothelin receptor** (ET_B receptor) agonist that displaces [ ¹²⁵I] ET-1 binding to ET_B receptors, with an IC₅₀ value of 0.2 nM. BQ-3020 elicits vasoconstriction in the rabbit pulmonary artery. BQ-3020 makes relaxation of the pig urinary bladder neck and can be used for cardiovascular disease research ¹ ².

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of **Endothelin Receptor**. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-P0207

Endothelin-2 (49-69), human endothelin-2 (human, canine); Human endothelin-2	Peptides	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P2496

Endothelin 1 (swine, human), Alexa Fluor 488-labeled	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-P2057

PD 142893	Endothelin Receptor	Cardiovascular Disease
PD 142893 is a **endothelin-B receptor** antagonist .

HY-P0204

Endothelin-3, human, mouse, rabbit, rat endothelin 3 (Rat,Human)	Peptides	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification endothelin 3 (Rat,Human) (TFA)	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P1018

IRL 1038	Endothelin Receptor	Neurological Disease
IRL 1038 is an **endothelin B receptor selective antagonist with a K_i** of 6-11 nM .

HY-12378

BQ-123 2 Publications Verification	Endothelin Receptor	Cardiovascular Disease
BQ-123 is a potent and selective **endothelin A (ETA) receptor antagonist with an IC₅₀ of 7.3 nM and a K_i** of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .

HY-16465

IRL-1620	Endothelin Receptor	Neurological Disease Endocrinology
IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM.

HY-16465A

IRL-1620 TFA 1 Publications Verification	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology
IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM .

HY-P4201

JKC 301	Vasopressin Receptor	Cardiovascular Disease
JKC 301 is a selective **Endothelin A receptor** antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking .

HY-102029

Sarafotoxin S6c SRTX-c	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6c (SRTX-c) is a potent **endothelin-B receptor** agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels .

HY-P10151

PD 156252	Endothelin Receptor	Cardiovascular Disease
PD 156252 is a hexapeptide that is a highly potent endothelin (ET) antagonist. PD 156252 has enhanced binding affinity for rabbit ETA and rat ETB receptor subtypes with IC50 values of 1.0 and 40 nM, respectively.

HY-P5130

Big endothelin-1 (rat 1-39)	Peptides	Cardiovascular Disease
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .

HY-P3563

[Lys4] Sarafotoxin S6c	Endothelin Receptor	Cardiovascular Disease
[Lys4] Sarafotoxin S6c, a sarafotoxin analogue, is a potent and partial agonist of **endothelin receptor. [Lys4] Sarafotoxin S6c elicits contraction of pig coronary artery, with an EC₅₀** of 1.5 nM .

HY-P3433

Sarafotoxin S6b	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective **endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the K_i** values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P990089

Patecibart	Endothelin Receptor	Cardiovascular Disease
Patecibart is a humanized immunoglobulin G4-kappa, anti-EDNRA monoclonal antibody. Patecibart is an **endothelin receptor** antagonist .

Recombinant Proteins Recommended:

Endothelin Receptor

Species:	Human (3)
Tag:	His (2) Fc (1)
Source:	HEK293 (2) E. coli Cell-free (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74180

	EDNRB/Endothelin R Type B Protein, Human (HEK293, His) EDNRB; endothelin receptor non-selective type; endothelin receptor type B; ETRB	Human	HEK293
	EDNRB/Endothelin R Type B Protein, a non-specific receptor for endothelin 1, 2, and 3, activates a phosphatidylinositol-calcium second messenger system through G proteins. This mechanism underscores its pivotal role in mediating cellular responses initiated by endothelin neuropeptides, emphasizing the versatility of EDNRB in transducing signals for various physiological processes. EDNRB/Endothelin R Type B Protein, Human (HEK293, His) is the recombinant human-derived EDNRB/Endothelin R Type B protein, expressed by HEK293 , with C-His labeled tag.

HY-P74181

	EDNRB/Endothelin R Type B Protein, Human (HEK293, Fc) EDNRB; endothelin receptor non-selective type; endothelin receptor type B; ETRB	Human	HEK293
	EDNRB/Endothelin R Type B Protein, a non-specific receptor for endothelin 1, 2, and 3, activates a phosphatidylinositol-calcium second messenger system through G proteins. This mechanism underscores its pivotal role in mediating cellular responses initiated by endothelin neuropeptides, emphasizing the versatility of EDNRB in transducing signals for various physiological processes. EDNRB/Endothelin R Type B Protein, Human (HEK293, Fc) is the recombinant human-derived EDNRB/Endothelin R Type B protein, expressed by HEK293, with C-mFc labeled tag. The total length of EDNRB/Endothelin R Type B Protein, Human (HEK293, Fc) is 75 a.a., with molecular weight of ~47.5 & 43.7 kDa, respectively.

HY-P700379

	EDNRB/Endothelin R Type B Protein, Human (Cell-Free, His) EDNRB; endothelin receptor non-selective type; endothelin receptor type B; ETRB	Human	E. coli Cell-free
	EDNRB/Endothelin R Type B Protein, a non-specific receptor for endothelin 1, 2, and 3, activates a phosphatidylinositol-calcium second messenger system through G proteins. This mechanism underscores its pivotal role in mediating cellular responses initiated by endothelin neuropeptides, emphasizing the versatility of EDNRB in transducing signals for various physiological processes. EDNRB/Endothelin R Type B Protein, Human (Cell-Free, His) is the recombinant human-derived EDNRB/Endothelin R Type B protein, expressed by E. coli Cell-free, with C-10*His labeled tag. The total length of EDNRB/Endothelin R Type B Protein, Human (Cell-Free, His) is 416 a.a., with molecular weight of 50.3 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-14184S

Macitentan-d4
Macitentan-d₄ is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

HY-17621S

Sparsentan-d5
Sparsentan-d₅ is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83510

	Endothelin Receptor B Antibody (YA3255) endothelin B receptor; ET-B; ET-BR; endothelin receptor non-selective type	WB, IP	Human
	Endothelin Receptor B Antibody (YA3255) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3255), targeting Endothelin Receptor B, with a predicted molecular weight of 50 kDa (observed band size: 50 kDa). Endothelin Receptor B Antibody (YA3255) can be used for WB, IP experiment in human background.

HY-P83206

	GPR37 Antibody (YA2951) GPR37; Probable G-protein coupled receptor 37; endothelin B receptor-like protein 1; ETBR-LP-1; Parkin-associated endothelin receptor-like receptor; PAELR	WB	Rat
	GPR37 Antibody (YA2951) is a biotin-conjugated non-conjugated IgG antibody, targeting GPR37, with a predicted molecular weight of 67 kDa (observed band size: 67 kDa). GPR37 Antibody (YA2951) can be used for WB experiment in rat background.

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endothelin receptor

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