endowed

By Targets:	Biochemical Assay Reagents (3) Complement System (2) COX (2) Drug Intermediate (1) Endogenous Metabolite (1) Fluorescent Dye (1) Opioid Receptor (1) Sodium Channel (1)
By Research Areas:	Cancer (3) Endocrinology (2) Metabolic Disease (1) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1345A

TLQP-21 TFA 1 Publications Verification	Complement System	Neurological Disease Endocrinology
TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions .

HY-170757A

Spermidine-alkyne trihydrochloride	Biochemical Assay Reagents	Others
Spermidine-alkyne trihydrochloride is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne trihydrochloride is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

HY-N2459

Peonidin chloride YGM-6 chloride	COX	Cancer
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

HY-D1716

S0456	Fluorescent Dye Drug Intermediate	Cancer
S0456 is a raw material that plays a crucial role in the construction of the folate receptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents .

HY-124754

Navacaprant BTRX-335140; CYM-53093	Opioid Receptor	Neurological Disease Metabolic Disease
Navacaprant (BTRX-335140) is a selective and orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC₅₀ values of 0.8 nM, 110 nM, and 6500 nM, respectively. Navacaprant endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. Navacaprant distributes well into the CNS and can be used for the research of neuropathy .

HY-W090294

Perylene Peri-dinaphthalene (purified by sublimation); Perylene	Biochemical Assay Reagents	Others
Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.

HY-P1345

TLQP-21	Complement System	Neurological Disease Endocrinology
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions .

HY-170757

Spermidine-alkyne	Biochemical Assay Reagents	Others
Spermidine-alkyne is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

HY-105084

Lubeluzole	Sodium Channel	Neurological Disease
Lubeluzole is a neuroprotective anti-ischemic compound. Lubeluzole, but not its (-)-R-isomer, protects against sensorimotor deficits provoked by photochemical stroke in rats. Lubeluzole inhibited glutamate-stimulated guanosine 3',5'-cyclic monophosphate production with an IC₅₀ of 37 nM. Lubeluzole also has the potential for developing a novel class of antibacterial adjuvants endowed with spasmolytic activity .

HY-W019831

Silicon dioxide Silica; Colloidal anhydrous silica	Endogenous Metabolite	Others
Silicon dioxide (Silica) serves as the core of gold-coated silica nanoparticles, featuring a spherical structure enveloped in a layer of gold nanoparticles on its surface. This composition endows them with distinctive chemical and optical properties, rendering them highly desirable for various applications in medicine, batteries, catalysis, sensors, and spectroscopy. The silica component provides a large surface area, a non-porous nature, outstanding charge transport capabilities, and biocompatibility.

HY-N2459R

Peonidin (chloride) (Standard)	COX	Cancer
Peonidin (chloride) (Standard) is the analytical standard of Peonidin (chloride). This product is intended for research and analytical applications. Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

Cat. No.	Product Name

HY-L198

Non-natural Amino Acid Compound Library	126 compounds
Unlike the 20 natural amino acids commonly found within living organisms, non-natural amino acids are synthesized through chemical or biosynthetic methods, thereby being endowed with unique chemical properties or biological activities. In drug development, these amino acids can be utilized to design novel pharmaceutical molecules that may exhibit superior pharmacological characteristics, such as increased selectivity, improved pharmacokinetic profiles, or reduced toxicity. In biomedical research, uon-natural amino acids can act as biological markers or probes for investigating biological processes like cell signaling, protein conformation, and protein-protein interactions. In addition, non-natural amino acids can also be used in the field of agriculture to develop new pesticides, plant growth regulators and so on.

Non-natural Amino Acid Compound Library

126 compounds

Unlike the 20 natural amino acids commonly found within living organisms, non-natural amino acids are synthesized through chemical or biosynthetic methods, thereby being endowed with unique chemical properties or biological activities. In drug development, these amino acids can be utilized to design novel pharmaceutical molecules that may exhibit superior pharmacological characteristics, such as increased selectivity, improved pharmacokinetic profiles, or reduced toxicity. In biomedical research, uon-natural amino acids can act as biological markers or probes for investigating biological processes like cell signaling, protein conformation, and protein-protein interactions. In addition, non-natural amino acids can also be used in the field of agriculture to develop new pesticides, plant growth regulators and so on.

HY-L175

Inflammasomes related Compound Library	99 compounds
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 99 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Inflammasomes related Compound Library

99 compounds

Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.

MCE designs a unique collection of 99 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Cat. No.	Product Name	Type

HY-D1716

S0456	Fluorescent Dyes/Probes
S0456 is a raw material that plays a crucial role in the construction of the folate receptor-targeted near-infrared dye OTL 38 (HY-139579). S0456 is connected to the modified folic acid to form OTL 38, endowing OTL 38 with good optical properties, high affinity, and specificity. S0456 can be used in the research of tumor optical imaging agents .

Cat. No.	Product Name	Type

HY-W090294

Perylene Peri-dinaphthalene (purified by sublimation); Perylene	Biochemical Assay Reagents
Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.

Perylene

Peri-dinaphthalene (purified by sublimation); Perylene

Biochemical Assay Reagents

Perylene, which is a polycyclic aromatic hydrocarbon composed of four linearly fused benzene rings, is commonly used as a pigment and dye in a variety of applications, including printing inks, plastics, and textiles. In addition, Perylene has potential uses in solar cells as photosensitizers and as fluorescent probes in biochemistry and materials science. Perylene's rigid planar structure endows it with unique electronic and optical properties, making it a versatile and important compound in many fields of chemistry and materials science.

Cat. No.	Product Name	Target	Research Area

HY-P1345A

TLQP-21 TFA 1 Publications Verification	Complement System	Neurological Disease Endocrinology
TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions .

HY-P1345

TLQP-21	Complement System	Neurological Disease Endocrinology
TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor 1 (C3aR1) agonist (EC₅₀: mouse TLQP-21=10.3 μM; human TLQP-21=68.8 μM). TLQP-21 activates C3aR1 to induce an increase of intracellular Ca ²⁺. TLQP-21 is used for the research in regulation of nociception and other relevant physiologic functions .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2459

Peonidin chloride YGM-6 chloride	Structural Classification Classification of Application Fields Source classification Plants Food Research Anthocyans Flavonoids Microorganisms Paeonia lactiflora Pall. Phenols Polyphenols Pigments Paeoniaceae Disease Research Fields Cancer	COX
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

HY-W019831

Silicon dioxide Silica; Colloidal anhydrous silica	Structural Classification Natural Products Animals Source classification	Endogenous Metabolite
Silicon dioxide (Silica) serves as the core of gold-coated silica nanoparticles, featuring a spherical structure enveloped in a layer of gold nanoparticles on its surface. This composition endows them with distinctive chemical and optical properties, rendering them highly desirable for various applications in medicine, batteries, catalysis, sensors, and spectroscopy. The silica component provides a large surface area, a non-porous nature, outstanding charge transport capabilities, and biocompatibility.

HY-N2459R

Peonidin (chloride) (Standard)	Structural Classification Anthocyans Flavonoids Microorganisms Paeonia lactiflora Pall. Source classification Phenols Polyphenols Plants Paeoniaceae	COX
Peonidin (chloride) (Standard) is the analytical standard of Peonidin (chloride). This product is intended for research and analytical applications. Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

Cat. No.	Product Name		Classification

HY-170757

Spermidine-alkyne		Alkynes
Spermidine-alkyne is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

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endowed

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Click Chemistry

Natural
Products