Search Result
Results for "
epimer
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
16
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-145263A
-
-
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- HY-160109A
-
|
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Mucin
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Cancer
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Ac5GalNTGc epimer is an analogue of hexosamine and the racemate of Ac5GalNTGc (HY-160109). Ac5GalNTGc inhibits mucin-type O-linked glycosylation biosynthesis .
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-
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- HY-136443
-
|
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Antibiotic
Bacterial
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Infection
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4-Epitetracycline hydrochloride is a reversible epimer of Tetracycline (HY-A0107) that can be interconverted in nature. 4-Epitetracycline hydrochloride exhibits antibacterial activity .
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-
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- HY-N0521
-
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Drug Isomer
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Metabolic Disease
Cancer
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(-)-Gallocatechin, an epimer of (-)-Epigallocatechin (EGC), is contained in various tea products. (-)-Gallocatechin has antioxidant activities .
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-
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- HY-137516A
-
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PROTACs
Ras
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Cancer
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LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849 .
|
-
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- HY-106365A
-
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Endogenous Metabolite
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Inflammation/Immunology
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Rofleponide epimer is a compound with anti-inflammatory activity. Rofleponide epimer has shown high selectivity in the lungs in experiments. Rofleponide epimer exhibits excellent pharmacological properties by efficiently binding to the rat thymic glucocorticoid receptor. The biotransformation rate of Rofleponide epimer is 10 times higher than that of other known similar drugs, indicating that it has potential application value in inhibiting inflammatory diseases involving mucosa .
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-
- HY-139620A
-
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PROTACs
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Others
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MS83 epimer 1 is the epimer of MS83 (HY-139620). MS83 is a proof-of-concept PROTAC by linking the KEAP1 ligand to a BRD4/3/2 binder .
|
-
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- HY-Z8754
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Tacrolimus EP impurity D; 8-epi-Tacrolimus
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Phosphatase
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Inflammation/Immunology
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Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone, an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2 .
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- HY-157660
-
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Drug Isomer
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Others
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15(R)-Prostaglandin F1α (compound 10) is the C-15 epimer of PGF1α .
|
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- HY-126069
-
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15(R)-Ciloprost; 15(R)-ZK 36374
|
Drug Isomer
|
Others
|
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15(R)-Iloprost is the unnatural or inverted C-15 epimer of lloprost (HY-A0096) .
|
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- HY-113887
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-
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- HY-136443R
-
|
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Reference Standards
Antibiotic
Bacterial
|
Infection
|
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4-Epitetracycline (hydrochloride) (Standard) is the analytical standard of 4-Epitetracycline (hydrochloride). This product is intended for research and analytical applications. 4-Epitetracycline hydrochloride is a reversible epimer of Tetracycline (HY-A0107) that can be interconverted in nature. 4-Epitetracycline hydrochloride exhibits antibacterial activity .
|
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-
- HY-145388B
-
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Drug Isomer
|
Cancer
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AU-16235 is an inactive epimer of AU-15330. AU-16235 has no effect on cancer cell survival and growth
|
-
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- HY-N0521R
-
|
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Reference Standards
Others
|
Metabolic Disease
Cancer
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(-)-Gallocatechin (Standard) is the analytical standard of (-)-Gallocatechin. This product is intended for research and analytical applications. (-)-Gallocatechin, an epimer of (-)-Epigallocatechin (EGC), is contained in various tea products. (-)-Gallocatechin has antioxidant activities .
|
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- HY-148124
-
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Drug Isomer
Parasite
Antibiotic
Bacterial
MMP
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Others
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6-Epi-doxycycline is the C-6 epimer of Doxycycline (HY-N0565), formed as a degradation impurity through epimerization of Doxycycline under abnormal conditions (e.g., high temperature, pH changes, or humidity). 6-Epi-doxycycline is commonly used for the detection and analysis of impurity levels in pharmaceutical formulations .
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- HY-N10677
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Others
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Cancer
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S-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. S-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC50 values of 4.49 and 3.61 μM for K562/R and K562/S, respectively. S-30-Hydroxygambogic acid can be used for the research of cancer .
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- HY-N10678
-
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Others
|
Cancer
|
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R-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. R-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC50 values of 2.89 and 1.27 μM for K562/R and K562/S, respectively. R-30-Hydroxygambogic acid can be used for the research of cancer .
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- HY-135383
-
|
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HMG-CoA Reductase (HMGCR)
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Cardiovascular Disease
|
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(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin Calcium (HY-B0144). Pitavastatin Calcium is a potent HMG-CoA reductase inhibitor that can be used for the study of cardiovascular disease .
|
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- HY-N0210
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-
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- HY-N0210S5
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-
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- HY-N0210S6
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-
-
- HY-N0210S7
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-
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- HY-N0210S8
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-
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- HY-N0210S9
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-
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- HY-N0210S11
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-
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- HY-127144
-
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α-Dihydrosaxitoxin
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Drug Derivative
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Neurological Disease
|
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α-Saxitoxinol is an epimer of Dihydtosaxitoxin and a derivative of saxitoxin. α-Saxitoxinol represents approximately 3.7% of the biological activity of Saxitoxin (a neurotoxin) .
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- HY-N1556
-
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Estrogen Receptor/ERR
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Metabolic Disease
Cancer
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Psidial A is an epimer of sesquiterpenoid-diphenylmethane meroterpenoid. Psidial A may act as a selective estrogen receptors modulator. Psidial A also has potential for anticancer research .
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- HY-161408A
-
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Phosphatase
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Others
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iGePhos1 is an inactive GePhos1 (HY-161408) epimer used as a nonbinding negative control. iGephos1 lacks the phosphatase recruiting possibility .
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-
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- HY-N0210S12
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- HY-N0210R
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-
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- HY-W399297
-
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7α,12α-Dihydroxycholanoic acid
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Endogenous Metabolite
|
Metabolic Disease
|
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Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is the 3β-epimer of ursodeoxycholic acid. Isodeoxycholic acid has the effect on choleresis and liver biochemistry .
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- HY-N0210S
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-
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- HY-N0210S2
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- HY-N0210S3
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- HY-15916
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DTE
2 Publications Verification
Dithioerythritol; Cleland’s reagent
|
Biochemical Assay Reagents
|
Others
|
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DTE (Dithioerythritol) is a sulfur-containing sugar derived from the corresponding 4-carbon monosaccharide erythrose. DTE is an epimer of Dithiothreitol (DTT) (HY-15917). DTE is a thiol reducing agent .
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- HY-N0210S1
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-
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- HY-N0210S4
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- HY-N0210S16
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-
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- HY-N11646
-
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Bacterial
|
Infection
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Ganorbiformin B is a lanostane triterpenoid. Ganorbiformin B shares the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T exhibits potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra .
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- HY-136257
-
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PROTACs
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Others
|
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CMP98, a PROTAC, is unable to induce degradation of VHL. CMP98 can be used as a negative control compound for CM11 . CMP98 consists of two von Hippel-Lindau ligands on their active domain.
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- HY-139907A
-
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Aminopeptidase
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Others
|
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DG013B is an epimer of DG013A (HY-139907). DG013B has weak affinity for ERAP1 and ERAP2 and is often used as a negative control to study the binding properties of DG013A and its analogues to ERAP1 and ERAP2 .
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- HY-W701205
-
|
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Isotope-Labeled Compounds
Antibiotic
|
Infection
|
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4-Epitetracycline-d6 is deuterated labeled 4-Epitetracycline hydrochloride (HY-136443) 4-Epitetracycline hydrochloride is an epimer of Tetracycline (HY-A0107). Tetracycline can undergo epimerization insolution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity.
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- HY-139907C
-
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Aminopeptidase
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Others
|
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DG013B formate is an epimer of DG013A (HY-139907). DG013B formate has weak affinity for ERAP1 and ERAP2 and is often used as a negative control to study the binding properties of DG013A and its analogues to ERAP1 and ERAP2 .
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- HY-113801R
-
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(Rac)-3-oxo-C8-HSL (Standard)
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Endogenous Metabolite
Reference Standards
|
Metabolic Disease
|
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4-Epitetracycline (hydrochloride) (Standard) is the analytical standard of 4-Epitetracycline (hydrochloride). This product is intended for research and analytical applications. 4-Epitetracycline hydrochloride is an epimer of Tetracycline (HY-A0107). Tetracycline can undergo epimerization in
solution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity .
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- HY-B1127R
-
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N-Benzoyl-β-alanine (Standard)
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Reference Standards
Bacterial
Antibiotic
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Others
|
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16α-Hydroxyprednisolone (Standard) is the analytical standard of 16α-Hydroxyprednisolone. This product is intended for research and analytical applications. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide via cytochrome P450 3A (CYP3A) enzymes .
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- HY-100449A
-
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Prostaglandin Receptor
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Endocrinology
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(S)-AL 8810 is an 11β-fluoro analog of PGF2α that acts as a potent and selective antagonist at the FP receptor. (S)-AL 8810 is the C-15 epimer of AL 8810, having the
inverse, (S), or "natural" configuration at C-15 relative to AL 8810, which is 15-(R) .
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- HY-117580
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OH-PRED
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Drug Metabolite
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Inflammation/Immunology
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16α-Hydroxyprednisolone (OH-PRED) is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily .
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- HY-120982
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Prostaglandin Receptor
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Endocrinology
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Cloprostenol is a synthetic prostaglandin F2α (PGF2α) analog and a potent FP receptor agonist. (+)-15-epi Cloprostenol is the 15(S), or 15β-hydroxy enantiomer of (+)-cloprostenol. This epimer is less active by several orders of magnitude as an FP receptor ligand when compared to 15(R)-cloprostenol. However, the specific activity of this isomer has not been well studied.
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- HY-32351B
-
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3-epi-25-hydroxy Cholecalciferol
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PTHR
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Endocrinology
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3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
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- HY-125527A
-
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17(R)-RvD1; AT-RvD1
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TRP Channel
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Inflammation/Immunology
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17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy .
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- HY-129937
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PROTACs
Epigenetic Reader Domain
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Cancer
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(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC) .
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- HY-117580S
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OH-PRED-d3
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Isotope-Labeled Compounds
Drug Metabolite
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Inflammation/Immunology
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16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily .
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- HY-117580R
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OH-PRED (Standard)
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Reference Standards
Drug Metabolite
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Inflammation/Immunology
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16α-Hydroxyprednisolone (OH-PRED) (Standard) is the analytical standard of 16α-Hydroxyprednisolone. This product is intended for research and analytical applications. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily .
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- HY-32351BR
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3-epi-25-hydroxy Cholecalciferol (Standard)
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PTHR
Reference Standards
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Endocrinology
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3-epi-Calcifediol (Standard) is the analytical standard of 3-epi-Calcifediol. This product is intended for research and analytical applications. 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
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- HY-145474
-
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Endogenous Metabolite
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Inflammation/Immunology
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17(R)-Resolvin D1 methyl ester is the methyl ester of Resolvin D1 (RvD1) (HY-125527) induced by Aspirin (HY-14654) with the 17R epimer (AT-RvD1). RvD is a regulator of transendothelial migration of human polymorphonuclear leukocytes and an anti-inflammatory agent. The 17R-trihydroxy-4Z of RvD1 also blocks transendothelial migration of human neutrophils (EC50 approximately 30 nM). AT-RvD1 is an effective form that protects against the rapid inactivation of Resolvin D1 .
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- HY-129922
-
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Prostaglandin Receptor
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Endocrinology
|
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Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki=0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.
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- HY-125527AS
-
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17(R)-RvD1-d5; AT-RvD1-d5
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Isotope-Labeled Compounds
TRP Channel
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Inflammation/Immunology
|
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17(R)-Resolvin D1-d5 (17(R)-RvD1-d5) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-15916
-
DTE
2 Publications Verification
Dithioerythritol; Cleland’s reagent
|
Biochemical Assay Reagents
|
|
DTE (Dithioerythritol) is a sulfur-containing sugar derived from the corresponding 4-carbon monosaccharide erythrose. DTE is an epimer of Dithiothreitol (DTT) (HY-15917). DTE is a thiol reducing agent .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-N0210S
-
|
|
|
D-Galactose- 13C is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
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- HY-N0210S5
-
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D-Galactose-d is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
|
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- HY-N0210S6
-
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D-Galactose-d-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
|
-
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- HY-N0210S7
-
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|
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D-Galactose-d-2 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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-
-
- HY-N0210S8
-
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D-Galactose-d-3 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-N0210S9
-
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|
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D-Galactose-d2 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-N0210S11
-
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D-Galactose-d2-1 is the deuterium labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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- HY-N0210S12
-
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D-Galactose- 13C,d is the deuterium and 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.
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-
- HY-N0210S2
-
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D-Galactose- 13C-3 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
|
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- HY-N0210S3
-
|
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D-Galactose- 13C-4 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
|
-
-
- HY-N0210S1
-
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D-Galactose- 13C-2 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
|
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-
- HY-N0210S4
-
|
|
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D-Galactose- 13C-5 is the 13C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose .
|
-
-
- HY-N0210S16
-
|
|
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D-Galactose- 13C6 is the C13 labeled D-Galactose (HY-N0210). D-Galactose is a natural aldohexose and C-4 epimer of glucose .
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-
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- HY-W701205
-
|
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|
4-Epitetracycline-d6 is deuterated labeled 4-Epitetracycline hydrochloride (HY-136443) 4-Epitetracycline hydrochloride is an epimer of Tetracycline (HY-A0107). Tetracycline can undergo epimerization insolution to 4-Epitetracycline hydrochloride, which shows a much lower antibiotic activity.
|
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-
- HY-117580S
-
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|
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16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily .
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- HY-125527AS
-
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17(R)-Resolvin D1-d5 (17(R)-RvD1-d5) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy .
|
-
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