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ergosterol

" in MedChemExpress (MCE) Product Catalog:

60

Inhibitors & Agonists

17

Natural
Products

8

Isotope-Labeled Compounds

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0181
    Ergosterol
    2 Publications Verification

    		 Endogenous Metabolite Inflammation/Immunology
    Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.
    Ergosterol
  • HY-N3845
    Ergosterol peroxide

    		Bacterial Inflammation/Immunology Cancer
    Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .
    Ergosterol peroxide
  • HY-N0181A
    Lumisterol

    9β,10α-ergosterol

    		 Endogenous Metabolite Metabolic Disease
    Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol (HY-N0181). Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities .
    Lumisterol
  • HY-117089
    Tetraconazole

    		Fungal Infection
    Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields . Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds .
    Tetraconazole
  • HY-119683
    Epoxiconazole

    		Fungal Infection
    Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases .
    Epoxiconazole
  • HY-N3846
    Ergosterol peroxide glucoside

    		Others Inflammation/Immunology
    Ergosterol peroxide glucoside is an Ergosterol derivative .
    Ergosterol peroxide glucoside
  • HY-W739754
    Ergosterol acetate

    		Others Others
    Ergosterol acetate is a natural compound that can be isolated from fungi .
    Ergosterol acetate
  • HY-N9142
    Ergosterol glucoside

    ergosterol 3-O-β-D-glucopyranoside

    		 Others Others
    Ergosterol glucoside is a phenolic compound that can be isolated from Tuber spp. truffles .
    Ergosterol glucoside
  • HY-159666
    Nystatin A1

    		Antibiotic Fungal Infection
    Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi .
    Nystatin A1
  • HY-119683S1
    Epoxiconazole-d4

    		Isotope-Labeled Compounds Fungal Infection
    Epoxiconazole-d4 is the deuterium labeled Epoxiconazole (HY-119683). Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases .
    Epoxiconazole-d4
  • HY-119683R
    Epoxiconazole (Standard)

    		Fungal Infection
    Epoxiconazole (Standard) is the analytical standard of Epoxiconazole. This product is intended for research and analytical applications. Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases .
    Epoxiconazole (Standard)
  • HY-14273
    Isavuconazole
    3 Publications Verification

    BAL-4815; RO-0094815

    		 Fungal Cytochrome P450 Antibiotic Infection
    Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
    Isavuconazole
  • HY-14273R
    Isavuconazole (Standard)

    		Fungal Cytochrome P450 Antibiotic Infection
    Isavuconazole (Standard) is the analytical standard of Isavuconazole. This product is intended for research and analytical applications. Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
    Isavuconazole (Standard)
  • HY-155710
    Antifungal agent 68

    		Fungal Infection
    Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .
    Antifungal agent 68
  • HY-17514
    Itraconazole
    10+ Cited Publications

    R51211

    		 Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial Infection Cancer
    Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
    Itraconazole
  • HY-17514R
    Itraconazole (Standard)

    		Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial Infection Cancer
    Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
    Itraconazole (Standard)
  • HY-113289
    Brassicasterol

    		Akt Androgen Receptor Bacterial Drug Metabolite HSV Infection Cardiovascular Disease Neurological Disease Cancer
    Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC50=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .
    Brassicasterol
  • HY-14282
    Lanoconazole

    		Fungal Infection Inflammation/Immunology
    Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    Lanoconazole
  • HY-14282A
    (Z)-Lanoconazole

    		Fungal Infection Inflammation/Immunology
    (Z)-Lanoconazole is the Z configuration of Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    (Z)-Lanoconazole
  • HY-14282R
    Lanoconazole (Standard)

    		Fungal Infection Inflammation/Immunology
    Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
    Lanoconazole (Standard)
  • HY-W020777
    Triflumizole

    		Fungal Infection
    Triflumizole is one of imidazole fungicides that works by inhibiting ergosterol biosynthesis, and is widely used for the control of powdery mildew and scabs on various fruits and crops .
    Triflumizole
  • HY-161091
    AM-2-19

    		Fungal Infection
    AM-2-19 (SF001) is an ergosterol-extracting polyene antifungal that is discovered through modifications to the amphotericin B toxin by chemists .
    AM-2-19
  • HY-B0221
    Amphotericin B
    Maximum Cited Publications
    15 Publications Verification

    		 Fungal Antibiotic Bacterial Parasite Infection Cancer
    Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
    Amphotericin B
  • HY-B0238
    Amorolfine hydrochloride

    Ro 14-4767/002

    		 Fungal Antibiotic Infection
    Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis .
    Amorolfine hydrochloride
  • HY-152249
    Antibacterial agent 131

    		Antibiotic Bacterial Fungal Infection
    Antibacterial agent 131 is a quinoline derivative. Antibacterial agent 131 has antimicrobial effect. Antibacterial agent 131 destroys the integrity of the fungal cells via blocking ergosterol production .
    Antibacterial agent 131
  • HY-121169
    Amorolfine

    Ro 14-4767; Ro 14-4767/000

    		 Fungal Infection
    Amorolfine (Ro 14-4767) is an antifungal agent. Amorolfine ameliorates the onychomycosis through inhibition of ergosterol biosynthesis. Amorolfine inhibits Candida albicans with a MIC of 0.404 µg/mL .
    Amorolfine
  • HY-135307
    SSF-109

    Huanjunzuo

    		 Fungal Infection
    SSF-109 is a broad-spectrum fungicide which has protective activity against plant disease. SSF-109 inhibits the biosynthesis of ergosterol at the 14α-demethylation step in Botrytis cinerea .
    SSF-109
  • HY-155711
    Antifungal agent 69

    		Fungal Infection
    Antifungal agent 69 (compound 13) is a eugenol-imidazole against Candida albicans (MIC: 4.6 μM) with no relevant cytotoxicity. Antifungal agent 69 alters the fungal ergosterol biosynthesis and shows antifungal activity .
    Antifungal agent 69
  • HY-N11015
    Withaphysalin R

    		Others Infection Inflammation/Immunology Cancer
    Withaphysalin R (compound 5) is a Withanolide that can be isolated from the Solanaceae. Withanolide is a steroid ester with an ergosterol skeleton, and some of these compounds have some significant activities, including cytotoxic and immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant .
    Withaphysalin R
  • HY-B0359
    Fenticonazole Nitrate
    3 Publications Verification

    REC 15-1476

    		 Fungal Antibiotic Infection
    Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis .
    Fenticonazole Nitrate
  • HY-B0221R
    Amphotericin B (Standard)

    		Fungal Antibiotic Bacterial Parasite Infection Cancer
    Amphotericin B (Standard) is the analytical standard of Amphotericin B. This product is intended for research and analytical applications. Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
    Amphotericin B (Standard)
  • HY-163297
    Antifungal agent 90

    		Fungal Infection
    Antifungal agent 90 (Compound 7n) is an antifungal agent that inhibits ergosterol biosynthesis. Antifungal agent 90 showed excellent antifungal activity against Valsa mali and Botrytis cinerea with EC50 values respectively. 4.26 and 1.41 μg/mL .
    Antifungal agent 90
  • HY-B0238R
    Amorolfine hydrochloride (Standard)

    		Fungal Antibiotic Infection
    Amorolfine (hydrochloride) (Standard) is the analytical standard of Amorolfine (hydrochloride). This product is intended for research and analytical applications. Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis .
    Amorolfine hydrochloride (Standard)
  • HY-B0221S
    Amphotericin B-13C6

    		Isotope-Labeled Compounds Cancer
    Amphotericin B- 13C6 is 13C labeled Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
    Amphotericin B-13C6
  • HY-76200
    Voriconazole
    5+ Cited Publications

    UK-109496

    		 Fungal Bacterial Infection Cancer
    Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
    Voriconazole
  • HY-114518
    Butenafine

    KP363

    		 Fungal Infection
    Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as  tinea pedis,  tinea cruris, tinea versicolor .
    Butenafine
  • HY-B0293A
    Butoconazole

    		Fungal Infection
    Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
    Butoconazole
  • HY-123037
    Triadimefon

    		Fungal Infection
    Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
    Triadimefon
  • HY-76200B
    Voriconazole camphorsulfonate

    UK-109496 camphorsulfonate

    		 Fungal Bacterial Infection
    Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
    Voriconazole camphorsulfonate
  • HY-143335
    Antifungal agent 52

    		Fungal Infection
    Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization .
    Antifungal agent 52
  • HY-76200S
    Voriconazole-d3

    UK-109496-d3

    		 Fungal Infection
    Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].
    Voriconazole-d3
  • HY-156252
    Antifungal agent 75

    		Fungal Infection
    Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity .
    Antifungal agent 75
  • HY-B0359R
    Fenticonazole Nitrate (Standard)

    		Fungal Antibiotic Infection
    Fenticonazole (Nitrate) (Standard) is the analytical standard of Fenticonazole (Nitrate). This product is intended for research and analytical applications. Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis .
    Fenticonazole Nitrate (Standard)
  • HY-76200R
    Voriconazole (Standard)

    UK-109496 (Standard)

    		 Fungal Bacterial Infection Cancer
    Voriconazole (Standard) is the analytical standard of Voriconazole. This product is intended for research and analytical applications. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
    Voriconazole (Standard)
  • HY-149614
    Laccase-IN-1

    		Endogenous Metabolite Fungal Infection
    Laccase-IN-1 (compound 4b) is an orally active inhibitor of laccase, with the IC50 of 11.3 μM. Laccase-IN-1displays protective and curative effects on apple fruits infected by B. dothidea. Laccase-IN-1 enhances the cell membrane permeability, destroys the mycelial surface morphology and the cell ultrastructure, and reduces the ergosterol and exopolysaccharide contents of B. dothidea .
    Laccase-IN-1
  • HY-123037R
    Triadimefon (Standard)

    		Fungal Infection
    Triadimefon (Standard) is the analytical standard of Triadimefon. This product is intended for research and analytical applications. Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
    Triadimefon (Standard)
  • HY-128033
    Fenpropimorph

    		Fungal Infection
    Fenpropimorph is a fungicide that inhibits the sterol pathway. Fenpropimorph inhibits δ8-δ7-sterol isomerase in yeast at low concentrations, with δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol. Fenpropimorph also inhibits sterol synthesis in certain plants and mammalian cells .
    Fenpropimorph
  • HY-W422288
    (Rac)-Ketoconazole

    (Rac)-Ketoconazol; (Rac)-R 41400

    		 Fungal Cytochrome P450 Infection
    (Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections .
    (Rac)-Ketoconazole
  • HY-17514S
    Itraconazole-d5

    R51211-d5

    		 Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Infection Cancer
    Itraconazole-d5 is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].
    Itraconazole-d5
  • HY-114518S2
    Butenafine-d4

    KP363-d4

    		 Fungal Isotope-Labeled Compounds Infection
    Butenafine-d4 (KP363-d4) is the deuterium labeled Butenafine (HY-114518). Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as ?tinea pedis, ?tinea cruris, tinea versicolor .
    Butenafine-d4

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