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flavus

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Apoptosis (1) Bacterial (5) DNA/RNA Synthesis (1) Endogenous Metabolite (3) Fungal (11) Gli (1) Interleukin Related (1) Lipoxygenase (1) Neurokinin Receptor (1) Opioid Receptor (1) Oxidative Phosphorylation (1) Pyruvate Kinase (1) SARS-CoV (2) Smo (1) TNF Receptor (1) Tyrosinase (2) α-synuclein (1)
By Research Areas:	Cancer (4) Infection (14) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116909

O-Methylsterigmatocystin	Others	Others
O-Methylsterigmatocystin is a metabolite in Aspergillus flavus and Aspergillus parasiticus .

HY-108416

5,7-Dihydroxy-4-methylphthalide	Others	Others
5,7-Dihydroxy-4-methylphthalide is a key intermediate in the synthesis of Mycophenolic acid and a secondary metabolite of Aspergillus flavus .

HY-B0856

Validamycin A	Fungal Tyrosinase Antibiotic	Infection
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a K_i of 5.893 mM .

HY-N7312

Ditryptophenaline (-)-Ditryptophenaline	Neurokinin Receptor	Inflammation/Immunology
Ditryptophenaline ((-)-Ditryptophenaline) is the metabolites of Aspergillus flavus. Ditryptophenaline inhibits substance P receptor and has anti-inflammatory activity .

HY-B0856R

Validamycin A (Standard)	Fungal Tyrosinase Antibiotic	Infection
Validamycin A (Standard) is the analytical standard of Validamycin A. This product is intended for research and analytical applications. Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM .

HY-19404

Embeconazole CS-758; R-120758	Fungal	Infection
Embeconazole (CS-758; R-120758) is an antifungal agent against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus and Aspergillus flavus, with MICs of 8, 16, 63 and 250 μM, respectively .

HY-N10080

Paspalinine	Others	Neurological Disease
Paspalinine is a tremorgenic metabolite that can be found in Aspergillus flavus .

HY-N9713

Dihydroxyaflavinine	Others	Others
Dihydroxyaflavinine (Compound Ⅲ) is an indole metabolite extracted from Aspergillus flavus .

HY-133709

β-Aflatrem	Others	Others
β-Aflatrem is a Diterpenoids product that can be isolated from From Aspergillus flavus .

HY-N7780

Aflatrem	Others	Neurological Disease
Aflatrem is a mycotoxin that can be isolated from Aspergillus flavus. Aflatrem has acute neurotoxic effects and can be ued in neurological disease .

HY-N8894

(-)-Isolariciresinol 9'-O-glucoside (-)-Isolariciresinol 3α-O-β-D-glucopyranoside	Others	Others
(-)-Isolariciresinol 9'-O-glucoside ((-)-Isolariciresinol 3α-O-β-D-glucopyranoside) is a Diterpenoids product that can be isolated from From Aspergillus flavus .

HY-N12056

Cyclo(L-leucyl-L-valyl)	Fungal	Infection
Cyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA. .

HY-N12016

Fulvotomentoside B	Others	Metabolic Disease
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-151410

Chitin synthase inhibitor 5	Fungal	Infection
Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC₅₀ value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .

HY-147804

SARS-CoV-2 3CLpro-IN-3	SARS-CoV Bacterial Fungal	Infection
SARS-CoV-2 3CLpro-IN-3 (Compound 3d) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities .

HY-E70120

Phosphomannose isomerase	Fungal	Infection
Phosphomannose isomerase is the first enzyme involved in the biosynthesis pathway of GDP-Man. Phosphomannose isomerase catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P). Phosphomannose isomerase is important for cell wall synthesis and protein glycosylation. Phosphomannose isomerase is a potent antifungal target to curb the threats posed by A. flavus .

HY-N7307

Pachybasin	Bacterial	Infection
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .

HY-165154

Cyclamidomycin Desdanine; Pyracrimycin A	Antibiotic Bacterial Fungal Pyruvate Kinase Oxidative Phosphorylation	Infection Inflammation/Immunology
Cyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml) .

HY-103027

Polyoxin B 5-(2-amino-5-O-carbamoyl-2-deoxy-L-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronic acid	Fungal	Infection Inflammation/Immunology
Polyoxin B is a potent chitin synthase inhibitor (IC₅₀=0.08 mM) and an effective antifungal agent .

HY-Y0337A

L-Cysteine hydrochloride 4 Publications Verification	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .

HY-162273

Antibacterial agent 189	Bacterial Smo Gli	Infection Cancer
Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins .

HY-151423

Antifungal agent 39	Fungal	Infection
Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent .

HY-Y0337AR

L-Cysteine hydrochloride (Standard)	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [4].

HY-147805

SARS-CoV-2 3CLpro-IN-4	SARS-CoV Bacterial Fungal	Infection
SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities .

HY-Y0790R

Cuminaldehyde (Standard)	Endogenous Metabolite Apoptosis DNA/RNA Synthesis α-synuclein Lipoxygenase Opioid Receptor Interleukin Related TNF Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Cuminaldehyde (Standard) is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL) and α-glucosidase (IC₅₀=0.5 mg/mL). Cuminaldehyde can modulate α-synuclein fibrils. Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

O-Methylsterigmatocystin	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
O-Methylsterigmatocystin is a metabolite in Aspergillus flavus and Aspergillus parasiticus .

Validamycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Fungal Tyrosinase Antibiotic
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a K_i of 5.893 mM .

Ditryptophenaline (-)-Ditryptophenaline	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Other Alkaloids Source classification Endogenous metabolite	Neurokinin Receptor
Ditryptophenaline ((-)-Ditryptophenaline) is the metabolites of Aspergillus flavus. Ditryptophenaline inhibits substance P receptor and has anti-inflammatory activity .

Validamycin A (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Fungal Tyrosinase Antibiotic
Validamycin A (Standard) is the analytical standard of Validamycin A. This product is intended for research and analytical applications. Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC₅₀ of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM .

Paspalinine	Structural Classification Alkaloids Microorganisms Source classification Indole Alkaloids	Others
Paspalinine is a tremorgenic metabolite that can be found in Aspergillus flavus .

Dihydroxyaflavinine	Structural Classification Alkaloids Microorganisms Source classification Indole Alkaloids	Others
Dihydroxyaflavinine (Compound Ⅲ) is an indole metabolite extracted from Aspergillus flavus .

β-Aflatrem	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
β-Aflatrem is a Diterpenoids product that can be isolated from From Aspergillus flavus .

Aflatrem	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
Aflatrem is a mycotoxin that can be isolated from Aspergillus flavus. Aflatrem has acute neurotoxic effects and can be ued in neurological disease .

(-)-Isolariciresinol 9'-O-glucoside (-)-Isolariciresinol 3α-O-β-D-glucopyranoside	Structural Classification Source classification Lignans Oplopanax horridus (Smith.) Miq. Phenylpropanoids Plants Araliaceae	Others
(-)-Isolariciresinol 9'-O-glucoside ((-)-Isolariciresinol 3α-O-β-D-glucopyranoside) is a Diterpenoids product that can be isolated from From Aspergillus flavus .

Cyclo(L-leucyl-L-valyl)	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Fungal
Cyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA. .

Fulvotomentoside B	Triterpenes Structural Classification Caprifoliaceae Terpenoids Source classification Plants Lonicera macrantha (D. Don) Spreng. Saccharides Monosaccharides	Others
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

Pachybasin	Infection Quinones Structural Classification Monophenols Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Disease Research Fields	Bacterial
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .

Cyclamidomycin Desdanine; Pyracrimycin A	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial Fungal Pyruvate Kinase Oxidative Phosphorylation
Cyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml) .

Polyoxin B 5-(2-amino-5-O-carbamoyl-2-deoxy-L-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronic acid	Classification of Application Fields Inflammation/Immunology Disease Research Fields	Fungal
Polyoxin B is a potent chitin synthase inhibitor (IC₅₀=0.08 mM) and an effective antifungal agent .

L-Cysteine hydrochloride 4 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .

L-Cysteine hydrochloride (Standard)	Structural Classification Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [4].

Cuminaldehyde (Standard)	Structural Classification Ketones, Aldehydes, Acids Rudbeckia laciniata L. Source classification Umbelliferae Plants Endogenous metabolite	Endogenous Metabolite Apoptosis DNA/RNA Synthesis α-synuclein Lipoxygenase Opioid Receptor Interleukin Related TNF Receptor
Cuminaldehyde (Standard) is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC₅₀= 0.00085 mg/mL) and α-glucosidase (IC₅₀=0.5 mg/mL). Cuminaldehyde can modulate α-synuclein fibrils. Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .

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flavus

Inhibitors & Agonists

NaturalProducts

Natural
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