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Results for "

geranylgeranyltransferase

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16229A
    GGTI-2154 hydrochloride

    		Apoptosis GGTase Cancer
    GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer .
    GGTI-2154 hydrochloride
  • HY-N7089
    Benzoyleneurea
    1 Publications Verification

    quinazolinedione

    		 Bacterial Infection
    Benzoyleneurea possesses anti-bacterial activity. Benzoyleneurea scaffold can be used in the synthesis of novel protein geranylgeranyltransferase-I (PGGTase-I) inhibitors .
    Benzoyleneurea
  • HY-12369
    GGTI-2133
    1 Publications Verification

    		 YAP Inflammation/Immunology
    GGTI-2133 is an inhibitor for geranylgeranyltransferase I (GGTase-I) with an IC50 of 38 nM. GGTI-2133 inhibits the geranylation of Rap-1A with an IC50 of 10 μM .
    GGTI-2133
  • HY-15871
    GGTI298 Trifluoroacetate
    5 Publications Verification

    		 Apoptosis Cancer
    GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM.
    GGTI298 Trifluoroacetate
  • HY-16231
    GGTI-2418

    		Apoptosis Cancer
    GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors .
    GGTI-2418
  • HY-16229
    GGTI-2154

    		Apoptosis Cancer
    GGTI-2154 is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 can be used for the research of cancer .
    GGTI-2154
  • HY-U00327
    Prenyl-IN-1

    		Farnesyl Transferase Neurological Disease
    Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.
    Prenyl-IN-1
  • HY-172423
    Darlifarnib

    		Farnesyl Transferase Cancer
    Darlifarnib (Compound (S)-058) is the inhibitor for farnesyl transferase and geranylgeranyltransferase with IC50 ≤ 10 nM and ＞ 1000 nM. Darlifarnib exhibits good metabolic stability in human and mouse liver microsomes with the half-life time ＞ 100 min .
    Darlifarnib
  • HY-100876
    GGTI298

    		Apoptosis Cancer
    GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
    GGTI298
  • HY-12369A
    GGTI-2133 TFA

    		YAP Inflammation/Immunology
    GGTI-2133 TFA is the TFA salt form of GGTI-2133 (HY-12369). GGTI-2133 TFA is an inhibitor for geranylgeranyltransferase I (GGTase-I) with an IC50 of 38 nM. GGTI-2133 TFA inhibits the geranylation of Rap-1A with an IC50 of 10 μM .
    GGTI-2133 TFA

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