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glucose utilization

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apical Sodium-Dependent Bile Acid Transporter (1) Biochemical Assay Reagents (1) Endogenous Metabolite (1) Glucokinase (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (3) Parasite (2)
By Research Areas:	Cardiovascular Disease (3) Endocrinology (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (11)

15

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Natural
Products

1

Isotope-Labeled Compounds

Targets Recommended: GLUT SGLT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Clorsulon L631529; MK401	Parasite	Infection
Clorsulon (L631529; MK401) is an orally active flukicidal agent against liver flukes (Fasciola hepatica and Fasciola gigantica) infections in calves and sheep. Clorsulon is also a competitive inhibitor of both 3-phosphoglycorate and ATP andinhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro .

HPPE Bach1-IN-1	Mitochondrial Metabolism	Metabolic Disease
HPPE (compound 236) is an orally active, potential Bach1 inhibitor. Bach1 is a transcription factor of the cap'n'collar type alkaline region leucine zipper factor family (CNC-bZip) that regulates mitochondrial metabolism and reduces glucose utilization. HPPE can be used for research in psoriasis, multiple sclerosis, and COPD .

D-Mannoheptulose	Others	Metabolic Disease
D-Mannoheptulose is a major non-structural carbohydrate in avocado. D-mannoheptulose is a specific inhibitor of *D-glucose* phosphorylation. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat .

KHG26693	Others	Metabolic Disease Inflammation/Immunology
KHG26693 is a thiazole derivative with anti-inflammatory and antioxidant properties. KHG26693 normalizes disturbed glucose metabolism by enhancing glucose utilization and decreasing liver glucose production via insulin release. KHG26693 is promising for research of diabetes .

Clorsulon (Standard)	Parasite	Infection
Clorsulon (Standard) is the analytical standard of Clorsulon. This product is intended for research and analytical applications. Clorsulon (L631529; MK401) is an orally active flukicidal agent against liver flukes (Fasciola hepatica and Fasciola gigantica) infections in calves and sheep.?Clorsulon is also a competitive inhibitor of both 3-phosphoglycorate and ATP andinhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro .

BM152054	Others	Metabolic Disease
BM152054 can promote glucose utilization in peripheral tissues by enhancing insulin action.

Piragliatin RO4389620	Glucokinase	Metabolic Disease
Piragliatin (RO4389620) is an activator for glucokinase, which reduces endogenous glucose production, increases β-cell function and glucose utilization, and thus decreases the blood glucose levels. Piragliatin exhibits antidiabetic efficacy .

Ritivixibat	Apical Sodium-Dependent Bile Acid Transporter	Cardiovascular Disease Metabolic Disease
Ritivixibat is an inhibitor of ileal bile acid transporter (IBAT), as well as a bile acid modulator. Ritivixibat can be used for research of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases .

D-Mannoheptulose-13C	Isotope-Labeled Compounds	Metabolic Disease
D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose. D-Mannoheptulose is a major non-structural carbohydrate in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation. D-Mannoheptulose can block insulin release and utilization

ASP8497	Others	Metabolic Disease
ASP8497 is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor that reduces blood glucose levels and increases plasma active GLP-1 and insulin levels without causing hypoglycemia in fasted normal mice. ASP8497 can be utilized for antihyperglycemic research .

β-Cyclodextrin hydrate Betadex hydrate	Biochemical Assay Reagents	Others
β-Cyclodextrin hydrate (Betadex hydrate) is a cyclic oligosaccharide composed of seven glucose units, featuring a hydrophobic central cavity and a hydrophilic outer surface. β-Cyclodextrin hydrate is utilized in an immunoassay method that leverages the complex formed by β-Cyclodextrin hydrate with small molecules to enhance the sensitivity of the immunodetection for these small molecules. β-Cyclodextrin hydrate is applicable for research in biosensing and immunoanalysis .

CP-316819 GPi 819	Others	Endocrinology
CP 316819 is a potent glycogen phosphorylase (GPase) inhibitor with antihyperglycemic effect (IC₅₀ values are 17 and 34 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and liver glycogen phosphorylase (huLGPa) respectively).CP 316819 causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low.CP-316819 prevents neuronal cell death and maintains brain electrical currents .

Ninerafaxstat IMB-1018972; IMB-101	Mitochondrial Metabolism	Cardiovascular Disease Metabolic Disease
Ninerafaxstat (IMB-1018972) is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat can be used for research on cardiovascular diseases .

Ninerafaxstat trihydrochloride MB-1018972 trihydrochloride; IMB-101 trihydrochloride	Mitochondrial Metabolism	Cardiovascular Disease Metabolic Disease
Ninerafaxstat trihydrochloride (IMB-1018972 trihydrochloride) is the trihydrochloride salt form of Ninerafaxstat (HY-139577). Ninerafaxstat trihydrochloride is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat trihydrochloride competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat trihydrochloride can be used for research on cardiovascular diseases .

(S)-Malic acid (Standard)	Endogenous Metabolite	Metabolic Disease
(S)-Malic acid (Standard) is the analytical standard of (S)-Malic acid. This product is intended for research and analytical applications. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive. In Vitro: It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L. casei. Furthermore, deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid, thus indicating that the cognate TC system regulates and is essential for the expression of ME. Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose, whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose .

Cat. No.	Product Name	Type

D-Glucose 6-phosphate potassium	Enzyme Substrates
D-Glucose 6-phosphate potassium is a biologically active compound that has the activity of being a substrate for glucose-6-phosphate isomerase. D-Glucose 6-phosphate potassium can participate in the sugar metabolism process and promote the production and utilization of energy in cells.

Cat. No.	Product Name	Category	Target	Chemical Structure

D-Mannoheptulose	Persea americana Mill Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Lauraceae Disease Research Fields Saccharides Monosaccharides	Others
D-Mannoheptulose is a major non-structural carbohydrate in avocado. D-mannoheptulose is a specific inhibitor of *D-glucose* phosphorylation. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat .

(S)-Malic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
(S)-Malic acid (Standard) is the analytical standard of (S)-Malic acid. This product is intended for research and analytical applications. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive. In Vitro: It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L. casei. Furthermore, deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid, thus indicating that the cognate TC system regulates and is essential for the expression of ME. Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose, whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose .

Cat. No.	Product Name	Chemical Structure

D-Mannoheptulose-13C
D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose. D-Mannoheptulose is a major non-structural carbohydrate in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation. D-Mannoheptulose can block insulin release and utilization

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