Ninerafaxstat trihydrochloride (Synonyms: MB-1018972 trihydrochloride; IMB-101 trihydrochloride)

Cat. No.: HY-139577A Purity: 99.65%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Ninerafaxstat trihydrochloride (IMB-1018972 trihydrochloride) is the trihydrochloride salt form of Ninerafaxstat (HY-139577). Ninerafaxstat trihydrochloride is a novel orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. Ninerafaxstat trihydrochloride competitively inhibits 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation, and shifts cardiac energy metabolism from free fatty acid oxidation to glucose oxidation, regulating myocardial substrate utilization and thereby improving cardiac efficiency. Ninerafaxstat trihydrochloride can be used for research on cardiovascular diseases.

For research use only. We do not sell to patients.

Ninerafaxstat trihydrochloride Chemical Structure

CAS No. : 2311824-72-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 427	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 427	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 590	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Other Forms of Ninerafaxstat trihydrochloride:

Ninerafaxstat Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

3-KAT, fatty acid oxidation^[1].

In Vitro

Ninerafaxstat trihydrochloride can reduce myocardial steatosis, improve left ventricular diastolic filling and myocardial energetics^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ninerafaxstat trihydrochloride (30 mg/kg; once daily; 4 weeks; via osmotic minipump) can improve left ventricular systolic function and reduce left ventricular end diastolic pressure (LVEDP) and myocardial fibrosis in a mouse model of heart failure after myocardial infarction^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Murine model of post-MI HF^[2].
Dosage:	30 mg/kg
Administration:	Via osmotic minipump; once daily; 4 weeks
Result:	Increased left ventricular ejection fraction (LVEF) and reduced cardiac fibrosis.

Clinical Trial

Molecular Weight

524.87

Formula

C₂₂H₃₂Cl₃N₃O₅

CAS No.

2311824-72-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CN=C1)OCCN2CCN(CC3=CC=C(OC)C(OC)=C3OC)CC2.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 41.67 mg/mL (79.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9052 mL	9.5262 mL	19.0523 mL
5 mM	0.3810 mL	1.9052 mL	3.8105 mL
10 mM	0.1905 mL	0.9526 mL	1.9052 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (248 KB) HNMR (275 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Moritz Hundertmark MD, et al. Kiosk 11R-TC-08 - Ninerafaxstat Modulates Cardiac Energy Metabolism in Cardio-metabolic Syndromes: A Mechanistic, Hyperpolarized MR Trial. Journal of Cardiovascular Magnetic Resonance. 2024; 26: 100325.

[2]. Paul Chamberlin, et al. IMB-1018792, A NOVEL FIRST-IN CLASS PARTIAL FATTY ACID OXIDATION INHIBITOR IMPROVES CARDIAC REMODELING AND FUNCTION POST-MYOCARDIAL INFARCTION. J Am Coll Cardiol. 2021 May 11;77(18):539.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9052 mL	9.5262 mL	19.0523 mL	47.6308 mL
	5 mM	0.3810 mL	1.9052 mL	3.8105 mL	9.5262 mL
	10 mM	0.1905 mL	0.9526 mL	1.9052 mL	4.7631 mL
	15 mM	0.1270 mL	0.6351 mL	1.2702 mL	3.1754 mL
	20 mM	0.0953 mL	0.4763 mL	0.9526 mL	2.3815 mL
	25 mM	0.0762 mL	0.3810 mL	0.7621 mL	1.9052 mL
	30 mM	0.0635 mL	0.3175 mL	0.6351 mL	1.5877 mL
	40 mM	0.0476 mL	0.2382 mL	0.4763 mL	1.1908 mL
	50 mM	0.0381 mL	0.1905 mL	0.3810 mL	0.9526 mL
	60 mM	0.0318 mL	0.1588 mL	0.3175 mL	0.7938 mL

Ninerafaxstat trihydrochloride Related Classifications

Metabolic Disease Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ninerafaxstat trihydrochloride2311824-72-1MB-1018972 trihydrochlorideIMB-101 trihydrochlorideMitochondrial Metabolismcardiac mitochondriafatty acidglucose oxidationcardiovascular diseaseInhibitorinhibitorinhibit

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