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Results for "

hTERT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Ferroptosis (1) G-quadruplex (3) Histone Methyltransferase (1) Telomerase (3)
By Research Areas:	Cancer (6) Inflammation/Immunology (1) Neurological Disease (1)

6

Inhibitors & Agonists

4

Peptides

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Telomerase-IN-3	Telomerase	Cancer
Telomerase-IN-3 is a telomerase inhibitor, which directly targets *hTERT* promoter activity. hTERT is the key component for maintenance of telomerase activity .

SOP1812 QN-302	G-quadruplex	Cancer
SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer .

*G4/hTERT-IN-4*	G-quadruplex	Cancer
G4/hTERT-IN-4 (compound b4) is a potent inhibitor of *G4/hTERT. G4/hTERT*-IN-4 plays an important role in cancer research .

Anticancer agent 239	Telomerase G-quadruplex Apoptosis Ferroptosis	Others
Anticancer agent 239 (Compound 5) is a ligand of hTERT promoter G-quadruplex DNA structures (hTERT G4) (K_d = 1.1 μM), and downregulates hTERT expression. Anticancer agent 239 decreases telomerase activity, shortens telomere length, and induces DNA damage, acute cellular senescence, and apoptosis. Anticancer agent 239 causes mitochondrial dysfunction, disrupts iron metabolism and activates ferroptosis in cancer cells. Anticancer agent 239 inhibits tumor growth in MDA-MB-231 xenograft mouse model .

Tertomotide hydrochloride GV-1001 hydrochloride	Telomerase	Neurological Disease
Tertomotide (GV1001) hydrochloride is peptide vaccine consists a 16-aa human telomerase reverse transcriptase (hTERT) sequence. Tertomotide hydrochloride shows neuroprotective. Tertomotide hydrochloride has the potential for the research of Alzheimer's disease .

UNC3866 TFA	Histone Methyltransferase	Cancer
UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC₅₀=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.

Cat. No.	Product Name	Target	Research Area

Tapderimotide hTERT (691–705)	Peptides	Inflammation/Immunology
Tapderimotide (hTERT (691–705)) is an immunological agent for active immunization .

Alrefimotide hTERT (660–689)	Peptides	Cancer
Alrefimotide is a hTERT-derived immunogenic peptide. Alrefimotide has a sequence of ALFSVLNYERARRPGLLGASVLGLDDIHRA. Alrefimotide can be used in cancer immunotherapy research .

Riletamotide hTERT (651-665)	Peptides	Cancer
Riletamotide is an immunological agent for active immunization .

UNC3866 TFA	Histone Methyltransferase	Cancer
UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC₅₀=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel.

Cat. No.	Compare	Product Name	Species	Source

	TERT Protein, Human (His) CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; TCS1; Telomerase associated protein 2; Telomerase catalytic subunit; Telomerase reverse transcriptase; Telomerase-associated protein 2; Telomere Reverse Transcriptase; TERT; TERT_HUMAN; TP2; TRT	Human	E. coli

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