SOP1812 (Synonyms: QN-302)

Name: SOP1812
Brand: MedChemExpress
SKU: HY-148012
Rating: 4.5 (1 reviews)

Cat. No.: HY-148012 Purity: 98.37%: FAQs
Data Sheet SDS COA Handling Instructions

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SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer.

For research use only. We do not sell to patients.

SOP1812 Chemical Structure

CAS No. : 2546091-70-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 741	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 741	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2050	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3280	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	2.6 nM Compound: 11; SOP1812	Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
CAPAN-1	GI₅₀	5.9 nM Compound: 11; SOP1812	Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
MIA PaCa-2	GI₅₀	1.3 nM Compound: 11; SOP1812	Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]
PANC-1	GI₅₀	1.4 nM Compound: 11; SOP1812	Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 32832034]

In Vitro

SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells^[1].
SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4^[1].
SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines
Concentration:	0-50 nM
Incubation Time:	96 hours
Result:	Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI₅₀ values of 1.3, 1.4, 5.9 and 2.6 nM, respectively.

Cell Viability Assay^[1]

Cell Line:	PANC-1 cells
Concentration:	0, 100, 400 and 800 nM
Incubation Time:	6 and 24 hours
Result:	Binded to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively.

Cell Viability Assay^[1]

Cell Line:	MIA PaCa-2 Cells
Concentration:	40 nM
Incubation Time:	6 and 24 hours
Result:	Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.

In Vivo

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female athymic nude mice with MIA PaCa-2 xenografts^[1]
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result:	Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.

Animal Model:	KPC mice with PDAC symptoms^[1]
Dosage:	1 mg/kg
Administration:	Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result:	Significantly extended survival of KPC mice and showed a better effect than gemcitabine.

Molecular Weight

791.98

Formula

C₄₅H₅₇N₇O₆

CAS No.

2546091-70-5

Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1C2=CC(NCCN3CCCC3)=C4C(N(CCCN5CCOCC5)C(C6=CC(C7=CC=C(CN8CCCC8)C=C7)=C(C2=C64)C(N1CCCN9CCOCC9)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (252.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2627 mL	6.3133 mL	12.6266 mL
5 mM	0.2525 mL	1.2627 mL	2.5253 mL
10 mM	0.1263 mL	0.6313 mL	1.2627 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.37%

Select Batch:

Data Sheet (289 KB) SDS (252 KB)

COA (252 KB) HNMR (331 KB) RP-HPLC (261 KB) LCMS (81 KB)

Handling Instructions (2659 KB)

References

[1]. Ahmed AA, et al. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2627 mL	6.3133 mL	12.6266 mL	31.5665 mL
	5 mM	0.2525 mL	1.2627 mL	2.5253 mL	6.3133 mL
	10 mM	0.1263 mL	0.6313 mL	1.2627 mL	3.1566 mL
	15 mM	0.0842 mL	0.4209 mL	0.8418 mL	2.1044 mL
	20 mM	0.0631 mL	0.3157 mL	0.6313 mL	1.5783 mL
	25 mM	0.0505 mL	0.2525 mL	0.5051 mL	1.2627 mL
	30 mM	0.0421 mL	0.2104 mL	0.4209 mL	1.0522 mL
	40 mM	0.0316 mL	0.1578 mL	0.3157 mL	0.7892 mL
	50 mM	0.0253 mL	0.1263 mL	0.2525 mL	0.6313 mL
	60 mM	0.0210 mL	0.1052 mL	0.2104 mL	0.5261 mL
	80 mM	0.0158 mL	0.0789 mL	0.1578 mL	0.3946 mL
	100 mM	0.0126 mL	0.0631 mL	0.1263 mL	0.3157 mL

SOP1812 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOP18122546091-70-5QN-302SOP 1812SOP-1812QN302QN 302G-quadruplexNDquadruplexMIA PaCa-2G4Wnt/β-cateninPANC-1BxPC-3PDACInhibitorinhibitorinhibit

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SOP1812 (Synonyms: QN-302)

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SOP1812 Related Antibodies

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Complete Stock Solution Preparation Table

SOP1812 Related Classifications

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