2. Search Result
Search Result
Results for "

hairpin

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

14

Peptides

1

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P5228A
    KSDSC TFA

    		Biochemical Assay Reagents Others
    KSDSC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .
    KSDSC TFA
  • HY-P5753A
    JB-95 acetate

    		Bacterial Infection
    JB-95 acetate, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 acetate can selectively disrupt the outer membrane but not the inner membrane of E. coli .
    JB-95 acetate
  • HY-P5753
    JB-95

    		Bacterial Infection
    JB-95, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 can selectively disrupt the outer membrane but not the inner membrane of E. coli .
    JB-95
  • HY-W728005
    Covidcil-19

    		SARS-CoV Infection
    Covidcil-19 (compound C5) avidly binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with a Kd of 11 nM. Covidcil-19 stabilizes the hairpin’s folded state and impairs frameshifting in cells. Covidcil-19 reduces frameshifting efficiency of the SARS-CoV-2 FSE and does not affect SARS-CoV-2 FSE RNA levels. Covidcil-19 inhibits a process essential for SARS-CoV-2 viral propagation .
    Covidcil-19
  • HY-P3926
    Amylin (8-37) (human)

    hIAPP (8-37)

    		 Amylin Receptor Metabolic Disease
    Amylin (8-37) (human) (hIAPP (8-37)) is a 8-37 fragment of human islet amyloid polypeptide (IAPP). The duplex folding structure in the Amylin (8-37) (human) assembly has a hairpin structure .
    Amylin (8-37) (human)
  • HY-P5228
    KSDSC

    		Biochemical Assay Reagents Others
    KSDSC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .
    KSDSC
  • HY-P1632
    Tachyplesin I

    		Bacterial Infection Cancer
    Tachyplesin I is a β-hairpin antimicrobial peptide that contains 17 amino acid residues. Tachyplesin I exhibits cytotoxic properties against various human tumor cell lines acting primarily by impairing the integrity of the outer cell membrane .
    Tachyplesin I
  • HY-P1631
    Polyphemusin I

    		Bacterial Infection
    Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges .
    Polyphemusin I
  • HY-P1632A
    Tachyplesin I TFA

    		Bacterial Infection Cancer
    Tachyplesin I TFA is a β-hairpin antimicrobial peptide that contains 17 amino acid residues. Tachyplesin I TFA exhibits cytotoxic properties against various human tumor cell lines acting primarily by impairing the integrity of the outer cell membrane .
    Tachyplesin I TFA
  • HY-148230
    TFEB Decoy ODN sodium

    		Interleukin Related HIF/HIF Prolyl-Hydroxylase Autophagy Others
    TFEB Decoy ODN sodium is a synthetic oligonucleotide with a hairpin ring structure, which were designed to inhibit Transcription factor EB (TFEB). TFEB decoy ODN inhibited fibrosis and autophagy in a UUO mouse model. The TFEB decoy ODNs also showed anti-inflammatory effects.
    TFEB Decoy ODN sodium
  • HY-P10820
    N36Mut(e,g)

    		HIV Infection
    N36Mut(e,g) is a gp41-targeted HIV fusion peptide inhibitor. N36Mut(e,g) acts by disrupting the homotrimeric coiled-coil of N-terminal helices in the pre-hairpin intermediate to form heterotrimers .
    N36Mut(e,g)
  • HY-P5071
    EcAMP3

    		Bacterial Infection
    EcAMP3 is a hairpin-like peptide. EcAMP3 has antifungal and antibacterial activity. EcAMPs precursor family contains seven identical cysteine motifs: C1XXXC2(11–13)C3XXXC4 .
    EcAMP3
  • HY-W587663
    4′-DTMP

    		Dihydrofolate reductase (DHFR) Infection
    4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFR WT) and 34.3 nM (DHFR L28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli .
    4′-DTMP
  • HY-E70094
    T4 UvsX Recombinase

    		DNA/RNA Synthesis Others
    T4 UvsX Recombinase helps initiate DNA replication on a double-stranded DNA template by catalyzing synapsis between the template and a homologous DNA single strand that serves as primer. T4 UvsX Recombinase greatly amplifies the snap-back (hairpin-primed) DNA synthesis that is catalyzed by the T4 DNA polymerase holoenzyme on linear, single-stranded DNA templates .
    T4 UvsX Recombinase
  • HY-125183
    BMS-818251

    		HIV Infection
    BMS-818251 is a potent, small-molecule inhibitor of HIV-1 entry with an EC50 value of 0.019 nM. BMS-818251 shows >10-fold higher potency than BMS-626529 (HY-15440) on a cross-clade panel of 208-HIV-1 strains. BMS-818251 interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency .
    BMS-818251
  • HY-P5601
    Thanatin

    		Bacterial Fungal Infection
    Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
    Thanatin
  • HY-P5601A
    Thanatin TFA

    		Bacterial Fungal Infection
    Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
    Thanatin TFA
  • HY-15843
    MIR96-IN-1

    		MicroRNA Apoptosis Cancer
    MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively . MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    MIR96-IN-1

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: