2. Anti-infection
  3. Bacterial
  4. JB-95

JB-95, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 can selectively disrupt the outer membrane but not the inner membrane of E. coli.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

JB-95 Chemical Structure

JB-95 Chemical Structure

CAS No. : 1873323-60-4

Size Price Stock Quantity
1 mg USD 110 In-stock
5 mg USD 325 In-stock
10 mg USD 520 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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JB-95 Related Antibodies

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Description

JB-95, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 can selectively disrupt the outer membrane but not the inner membrane of E. coli[1].

Molecular Weight

1971.41

Formula

C92H151N35O14
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

cyclo-(Trp-Arg-Ile-Arg-Ile-{d-Arg}-Trp-Lys-Arg-Leu-Arg-Arg-{d-Pro}-Pro)
Sequence Shortening

cyclo-(WRIRI-{d-Arg}-WKRLRR-{d-Pro}-P)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (50.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5073 mL 2.5363 mL 5.0725 mL
5 mM 0.1015 mL 0.5073 mL 1.0145 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5073 mL 2.5363 mL 5.0725 mL 12.6813 mL
5 mM 0.1015 mL 0.5073 mL 1.0145 mL 2.5363 mL
10 mM 0.0507 mL 0.2536 mL 0.5073 mL 1.2681 mL
15 mM 0.0338 mL 0.1691 mL 0.3382 mL 0.8454 mL
20 mM 0.0254 mL 0.1268 mL 0.2536 mL 0.6341 mL
25 mM 0.0203 mL 0.1015 mL 0.2029 mL 0.5073 mL
30 mM 0.0169 mL 0.0845 mL 0.1691 mL 0.4227 mL
40 mM 0.0127 mL 0.0634 mL 0.1268 mL 0.3170 mL
50 mM 0.0101 mL 0.0507 mL 0.1015 mL 0.2536 mL
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JB-95 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JB-951873323-60-4JB95JB 95BacterialInhibitorinhibitorinhibit

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