hypothalamic hormone

By Targets:	GHSR (3) GnRH Receptor (1) CRFR (3) Endogenous Metabolite (1) Melanocortin Receptor (1) Neurokinin Receptor (1) Oxytocin Receptor (1)
By Research Areas:	Cancer (2) Endocrinology (12) Metabolic Disease (1) Neurological Disease (1)

Targets Recommended: Thyroid Hormone Receptor Nuclear Hormone Receptor 4A/NR4A PTHR GHR GHSR TSH Receptor GnRH Receptor MCHR1 (GPR24)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0089A

Human growth hormone-releasing factor TFA Growth hormone Releasing Factor human TFA; Somatorelin (1-44) amide (human) (TFA)	GHSR	Endocrinology
Human growth hormone-releasing factor TFA (Growth Hormone Releasing Factor human TFA) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary .

HY-P4675

LHRH free acid	GnRH Receptor	Endocrinology
LHRH (free acid), the luteinizing hormone-releasing hormone, is a neuropeptide hypothalamic. LHRH regulates reproduction. LHRH can be used for the research of cancer .

HY-17571

Oxytocin 10+ Cited Publications α-Hypophamine; Oxytocic hormone	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-P0089

Human growth hormone-releasing factor Growth hormone Releasing Factor human; Somatorelin (1-44) amide (human)	GHSR	Endocrinology
Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary .

HY-P3685

[Met(O)21] Corticotropin Releasing Factor, ovine	CRFR	Endocrinology
[Met(O)21] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor isolated from ovine hypothalamic extracts. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH) .

HY-P3683

a-Helical Corticotropin Releasing Factor (12-41)	CRFR	Endocrinology
a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect .

HY-P3684

[DPro5] Corticotropin Releasing Factor, human, rat	CRFR	Endocrinology
[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .

HY-119332

3-Keto petromyzonol	Others	Endocrinology
3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey .

HY-18678

Bremelanotide PT-141	Melanocortin Receptor	Endocrinology
Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders .

HY-129207

JMV 3002	GHSR	Endocrinology
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC₅₀ value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg.

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

Cat. No.	Product Name	Type

HY-W583271

Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol	Cell Assay Reagents
Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor, and inhibiting HO activity can reduce the release of hypothalamic hormones like AVP, OT, and ANP caused by hyperosmolarity. Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol can be used for research on hyperbilirubinemia .

Cat. No.	Product Name	Target	Research Area

HY-P0089A

Human growth hormone-releasing factor TFA Growth hormone Releasing Factor human TFA; Somatorelin (1-44) amide (human) (TFA)	GHSR	Endocrinology
Human growth hormone-releasing factor TFA (Growth Hormone Releasing Factor human TFA) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary .

HY-P4675

LHRH free acid	GnRH Receptor	Endocrinology
LHRH (free acid), the luteinizing hormone-releasing hormone, is a neuropeptide hypothalamic. LHRH regulates reproduction. LHRH can be used for the research of cancer .

HY-P0238

Gastrin-Releasing Peptide, human	Peptides	Cancer
Gastrin-Releasing Peptide, human (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release.

HY-17571

Oxytocin 10+ Cited Publications α-Hypophamine; Oxytocic hormone	Oxytocin Receptor Endogenous Metabolite	Endocrinology Cancer
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-P0089

Human growth hormone-releasing factor Growth hormone Releasing Factor human; Somatorelin (1-44) amide (human)	GHSR	Endocrinology
Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary .

HY-P3685

[Met(O)21] Corticotropin Releasing Factor, ovine	CRFR	Endocrinology
[Met(O)21] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor isolated from ovine hypothalamic extracts. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH) .

HY-P3687

[Tyr0] Corticotropin Releasing Factor, ovine	Peptides	Endocrinology
[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin .

HY-P3683

a-Helical Corticotropin Releasing Factor (12-41)	CRFR	Endocrinology
a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect .

HY-P3684

[DPro5] Corticotropin Releasing Factor, human, rat	CRFR	Endocrinology
[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat .

HY-18678

Bremelanotide PT-141	Melanocortin Receptor	Endocrinology
Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders .

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

HY-P2110

RS-18286	Peptides	Others
RS-18286 is a potent LHRH antagonist studied for its effects on pituitary hormone secretion in sexually active rams. Injection of RS-18286 resulted in an immediate suppression of pulsatile LH secretion, accompanied by a decrease in testosterone levels, while FSH and PRL levels remained unchanged. The duration of LH suppression was dose-related, lasting approximately 4.3 to 31.8 hours for low to high doses, respectively. During the recovery phase, a compensatory increase in LH pulse frequency was observed, suggesting a response to diminished testosterone feedback. Even at the lowest dose, RS-18286 transiently reduced testosterone levels, demonstrating an effect on acute hypothalamic sensitivity to changes in hormonal feedback .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17571

Oxytocin 10+ Cited Publications α-Hypophamine; Oxytocic hormone	Structural Classification Natural Products Monophenols Classification of Application Fields Animals Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Oxytocin Receptor Endogenous Metabolite
Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

HY-119332

3-Keto petromyzonol	Classification of Application Fields Animals Source classification Disease Research Fields Endocrinology Steroids	Others
3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey .

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hypothalamic hormone

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