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STING-IN-3 is an inhibitor of stimulator of interferongenes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING .
STING agonist-16 (1a) is a specific stimulator of interferongenes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool .
STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferongenes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer .
ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.
Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferongenes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .
BSP16 is a potent, orally active stimulator of interferongenes (STING) agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer .
CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferongenes .
MEDS433 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 1.2 nM. MEDS433 exerts a potent antiviral activity against RSV-A and RSV-B in the one-digit nanomolar range. MEDS433 induces the expression of antiviral proteins encoded by interferon stimulated genes (ISGs) able to reduce RSV replication .
STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferongenes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer .
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferongenes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferongenes(STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferongenes(STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
Cyclic GMP- 13C, 15N2 is 13C and 15N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferongenes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .
Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferongenes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferongenes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research .
diABZI STING agonist-1 is a selective stimulator of interferongenes(STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferongenes(STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
STING agonist-13 is a stimulator of interferongenes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate STING downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .
diABZI STING agonist-1 tautomerism (compound 3) is a selective stimulator of interferongenes(STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
Tanshinlactone is a seco-abietanoid that can be isolated from Salvia miltiorrhiza. Tanshinlactone is a coronavirus (CoV) inhibitor. Tanshinlactone modulates interleukin-2 and interferon-γ gene expression .
Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferongenes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research .
Dazostinag (TAK-676 free base) is an agonist of stimulator of interferongenes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs) .
2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferongenes (STING), leads to potent and systemic tumor regression and immunity .
RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon . RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity .
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferongenes (STING), leads to potent and systemic tumor regression and immunity .
STING18 (Stimulator of interferongenes 18) is a compound that inhibits STING protein by utilizing a small molecule active site dimer, with good oral exposure, slow binding kinetics, and functional inhibitory activity on STING-mediated cytokine release.
Iso5-2DC18 is a lipid that can be used for the synthesis of amine containing lipids. These amine containing lipids can be used for mRNA delivery, activate the stimulator of interferongenes (STING) pathway, and exhibit anti-tumor immunity .
Antitumor agent-114 is a potent stimulator of interferongenes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research .
STING agonist-4 is an stimulator of InterferonGenes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function .
IACS-8779 disodium is a highly potent stimulator of interferongenes (STING) agonist with robust systemic antitumor efficacy. IACS-8779 disodium shows robust activation of the STING pathway in vitro and a superior systemic anti-tumor response in the B16 murine model of melanoma .
BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferongenes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research .
GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by
EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes .
3-Methyl-chuangxinmycin is an antibiotic. 3-Methyl-chuangxinmycin can affect the translation process in bacteria and mammalian cells by inhibiting the enzyme that synthesizes tryptophan tRNA (TrpRS). 3-Methyl-chuangxinmycin can downregulate genes related to interferon, TNF, and inflammatory responses in RDEB_L1 cells .
Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferongenes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 activities.
2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (ADU-S100 enantiomer ammonium salt) is the less active enantiomer of 2’3’-c-di-AM(PS)2 (Rp,Rp). 2’3’-c-di-AM(PS)2 (Rp,Rp) is an activator of stimulator of interferongenes (STING) .
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively .
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .
2’,3’-cGAMP-C2-PPA is a cyclic dinucleotide interferongene-stimulating protein (STING) agonist. 2’,3’-cGAMP-C2-PPA is a drug conjugated conjugate used to target antibody-drug conjugated conjugate (ADC) for the treatment of cancer. 2’,3’-cGAMP-C2-PPA can be used in the study of immune and tumor-related diseases .
PROTAC STING degrader-2 is a protein Degrader that targets Stimulator of interferongenes (STING) (DC50=0.53 μM). PROTAC STING Degrader-2 is combined with STING protein and E3 ubiquitin ligase in a covalent manner to induce the degradation of STING protein. PROTAC STING Degrader-2 can be used to investigate the role of STING in autoinflammation and autoimmune diseases (PINK: STING binder (HY-145009); Blue: VHL ligand (HY-164043); Black: linker) .
STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferongene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 (HY-136927) or 2’, 3’ -cGAMP (HY-100564)-stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases .
JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD) .
B8R 20-27 is a biological active peptide. (This is amino acids 20 to 27 fragment of B8R, a vaccinia virus (VV) gene that encodes a secreted protein related to gamma interferon receptor. B8R binding to IFN-g neutralizes its antiviral activity.)
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function .
Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferongenes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferongenes(STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferongenes(STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively .
Tanshinlactone is a seco-abietanoid that can be isolated from Salvia miltiorrhiza. Tanshinlactone is a coronavirus (CoV) inhibitor. Tanshinlactone modulates interleukin-2 and interferon-γ gene expression .
The IFI27L2A protein critically regulates interferon-induced transcriptional activity, specifically NR4A1, NR4A2, and NR4A3. Its interaction with XPO1 enhances the nuclear export of these receptors, with potential vascular effects on the injury response. IFI27L2A Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived IFI27L2A protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of IFI27L2A Protein, Mouse (Cell-Free, His) is 66 a.a., with molecular weight of 7.3 kDa.
IFN-alpha 5/IFNA5 Protein, Rat (HEK293, C-His) is the recombinant rat-derived IFN-alpha 5/IFNA5, expressed by HEK293 , with C-6*His labeled tag. The total length of IFN-alpha 5/IFNA5 Protein, Rat (HEK293, C-His) is 166 a.a.,
Cyclic GMP- 13C, 15N2 is 13C and 15N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferongenes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .
10 kDa interferon gamma induced protein; C7; Chemokine (C X C motif) ligand 10; Chemokine CXC motif ligand 10; Crg 2; CRG2; CXCL 10; CXCL10; Gamma IP10; gIP 10; GIP10; IFI 10; IFI10; INP 10; INP10; interferon activated gene 10; interferon gamma induced cell line; interferon inducible cytokine IP 10; MOB1; SCYB 10; SCYB10; Small inducible cytokine B10; Small inducible cytokine B10 precursor; Small inducible cytokine subfamily B (Cys X Cys) member 10; Gamma-IP-10.
ELISA, IHC-P, IHC-F, FC, ICC/IF
Human, Mouse, Rat,
CXCL10/IP10 Antibody is an unconjugated, approximately 10 kDa, rabbit-derived, anti-CXCL10/IP10 polyclonal antibody. CXCL10/IP10 Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, background without labeling.
PRDM1/Blimp1 Antibody (YA1101) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1101), targeting PRDM1/Blimp1. PRDM1/Blimp1 Antibody (YA1101) can be used for IHC-P experiment in human background.
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