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knee osteoarthritis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (1) MMP (1) NO Synthase (1) P2X Receptor (3) Prostaglandin Receptor (1) TGF-β Receptor (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (8) Neurological Disease (1)

6

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Inhibitory Antibodies

1

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Gefapixant MK-7264; AF-219	P2X Receptor	Inflammation/Immunology
Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis .

Gefapixant citrate MK-7264 citrate; AF-219 citrate	P2X Receptor	Inflammation/Immunology
Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis .

Nadecnemab	TGF-β Receptor	Inflammation/Immunology
Nadecnemab is an IgG4κ antibody targeting to GFRA3, glial cell derived neurotrophic factor family receptor alpha 3. Nadecnemab can be used for research of osteoarthritis of the knee/pain .

PG 116800 PG 530742; PGE 530742; PGE 7113313	MMP	Inflammation/Immunology
PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research .

Amtolmetin guacil	Prostaglandin Receptor COX NO Synthase	Inflammation/Immunology
Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis .

Gefapixant (Standard)	P2X Receptor	Inflammation/Immunology
Gefapixant (Standard) is the analytical standard of Gefapixant. This product is intended for research and analytical applications. Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis .

Cat. No.	Product Name	Type

Collagen, Type II, from bovine snout membrane Collagen	Native Proteins
Collagen, Type II, from bovine snout membrane is a type II collagen that can induce osteoarthritis by eliciting a strong and sustained T cell response. Type II collagen can be used to model collagen-induced arthritis in mice .

Cat. No.	Product Name	Target	Research Area

Fasinumab	Inhibitory Antibodies	Inflammation/Immunology
Fasinumab (Anti-Human NGF) is a human IgG4 monoclonal antibody to nerve growth factor (NGF). Fasinumab can be used in acute sciatica and knee osteoarthritis (OA) studies .

Nadecnemab	TGF-β Receptor	Inflammation/Immunology
Nadecnemab is an IgG4κ antibody targeting to GFRA3, glial cell derived neurotrophic factor family receptor alpha 3. Nadecnemab can be used for research of osteoarthritis of the knee/pain .

Tanezumab RN-624; PF 4383119	Inhibitory Antibodies	Neurological Disease Inflammation/Immunology Cancer
Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia .

Cat. No.	Product Name	Category	Target	Chemical Structure

Tanezumab RN-624; PF 4383119	Classification of Application Fields Disease Research Fields Cancer	Others
Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia .

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