muscle myosin

By Targets:	Myosin (13) Calmodulin (1) Na+/K+ ATPase (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (4) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (4)

Targets Recommended: Myosin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148516

MPH-220	Myosin	Neurological Disease
MPH-220 is a selective and orally active inhibitor of skeletal muscle *myosin-2. MPH-220 enables muscle* relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness .

HY-148799

Sevasemten	Myosin	Others
Sevasemten is an orally active allosteric inhibitor of skeletal muscle *myosin* that protects skeletal muscle from contraction-induced injury. Sevasemten exhibits selectively *myosin* inhibition with IC₅₀s of ≤10 μM (skeletal), >100 μM (cardiac), respectively. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models .

HY-Y0413

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle *myosin-II*. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

HY-148516A

(R)-MPH-220	Myosin	Neurological Disease
(R)-MPH-220 is the R isomer of MPH-220 (HY-148516). MPH-220 is a selective and orally active inhibitor of skeletal muscle *myosin-2. MPH-220 enables muscle* relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness .

HY-16690

BTS 2 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of *skeletal muscle* myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀*s of ~5 μM for actin- and Ca ²⁺-stimulated myosin* S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

HY-152190

JB002	Myosin	Cardiovascular Disease
JB002 is a myosin II inhibitor, with an IC₅₀ of ≤10 μM. JB002 can be used for the research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .

HY-152205

JB061	Myosin	Others
JB061 is a nonmuscle myosin inhibitor with IC₅₀s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (*Smooth muscle* myosin II), respectively. JB061 poorly decreases ATPase activity (IC₅₀>200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC₅₀** value of 39 μM .

HY-13441

(-)-Blebbistatin 10+ Cited Publications	Myosin	Cardiovascular Disease Cancer
(-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II .

HY-P5998

Myosin Light Chain Kinase Substrate (smooth muscle)	Myosin	Cancer
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate .

HY-152206

JB062	Myosin	Neurological Disease
JB062 is a nonmuscle myosin inhibitor with IC₅₀ values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .

HY-100685

MS-444 1 Publications Verification BE-34776	Myosin	Cancer
MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC₅₀ value of 10 μM.

HY-13441G

(-)-Blebbistatin (GMP)	Myosin	Cardiovascular Disease Cancer
(-)-Blebbistatin (GMP) is (-)-Blebbistatin (HY-13441) produced by using GMP guidelines. (-)-Blebbistatin (GMP) is a selective inhibitor of the ATPase activity of non-muscle myosin II .

HY-13813

Blebbistatin Maximum Cited Publications 20 Publications Verification	Myosin	Others
Blebbistatin is a selective *non-muscle* myosin II (NMII)** inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration .

HY-P1805

Calmodulin Binding Peptide 1	Calmodulin	Neurological Disease
Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca ²⁺ release .

Cat. No.	Product Name	Type

HY-13441G

(-)-Blebbistatin (GMP)	Fluorescent Dye
(-)-Blebbistatin (GMP) is (-)-Blebbistatin (HY-13441) produced by using GMP guidelines. (-)-Blebbistatin (GMP) is a selective inhibitor of the ATPase activity of non-muscle myosin II .

HY-133885

S-(-)-7-Desmethyl-8-nitro blebbistatin	Dyes
S-(-)-7-Desmethyl-8-nitro blebbistatin (compound 12) is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor .

Cat. No.	Product Name	Type

HY-13441G

(-)-Blebbistatin (GMP)	Biochemical Assay Reagents
(-)-Blebbistatin (GMP) is (-)-Blebbistatin (HY-13441) produced by using GMP guidelines. (-)-Blebbistatin (GMP) is a selective inhibitor of the ATPase activity of non-muscle myosin II .

Cat. No.	Product Name	Target	Research Area

HY-P5998

Myosin Light Chain Kinase Substrate (smooth muscle)	Myosin	Cancer
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate .

HY-P10346

smMLCK peptide Smooth-muscle myosin Light-Chain Kinase (796-815)	Peptides	Cardiovascular Disease Inflammation/Immunology
smMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK). The smMLCK peptide mimics the substrate and competitively inhibits the binding of the actual substrate to the enzyme, thereby inhibiting the kinase activity. This inhibition prevents the phosphorylation of the myosin light chain, thus inhibiting muscle contraction .

HY-P10165

MLCK Peptide	Peptides	Metabolic Disease
MLCK Peptide is a fully reversible, high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase .

HY-P1805

Calmodulin Binding Peptide 1	Calmodulin	Neurological Disease
Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca ²⁺ release .

Species:	Human (2)
Tag:	SUMO (1) His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71532

	MYBPC3 Protein, Human (His-SUMO) C protein cardiac muscle isoform; C-protein; cardiac muscle isoform; Cardiac MyBP C; Cardiac MyBP-C; Cardiac myosin binding protein C ; cardiac-type; CMH4; FHC; MYBP C; MYBPC; MYBPC3; myosin binding protein C cardiac; myosin binding protein C cardiac-type; myosin-binding protein C; myosin-binding protein C cardiac type; MYPC3_HUMAN	Human	E. coli
	MYBPC3 Protein, positioned in the crossbridge region of vertebrate striated muscle A bands, binds to myosin heavy chain (MHC), F-actin, and native thin filaments, influencing actin-activated myosin ATPase. Its presence suggests potential modulation of muscle contraction, indicating a functional impact on the contractile apparatus, or a structural role in muscle fibers. MYBPC3 Protein, Human (His-SUMO) is the recombinant human-derived MYBPC3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P71532A

	MYBPC3 Protein, Human (HEK293, His) C protein cardiac muscle isoform; C-protein; cardiac muscle isoform; Cardiac MyBP C; Cardiac MyBP-C; Cardiac myosin binding protein C ; cardiac-type; CMH4; FHC; MYBP C; MYBPC; MYBPC3; myosin binding protein C cardiac; myosin binding protein C cardiac-type; myosin-binding protein C; myosin-binding protein C cardiac type; MYPC3_HUMAN	Human	E. coli
	MYBPC3 Protein, positioned in the crossbridge region of vertebrate striated muscle A bands, binds to myosin heavy chain (MHC), F-actin, and native thin filaments, influencing actin-activated myosin ATPase. Its presence suggests potential modulation of muscle contraction, indicating a functional impact on the contractile apparatus, or a structural role in muscle fibers. MYBPC3 Protein, Human (HEK293, His) is the recombinant human-derived MYBPC3 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83388

	MYLK Antibody (YA3133) KMLS; KRP; MLCK; MYLK; myosin light chain kinase; smooth muscle and non-muscle isozymes; myosin light polypeptide kinase; telokin	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	MYLK Antibody (YA3133) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3133), targeting MYLK, with a predicted molecular weight of 211 kDa. MYLK Antibody (YA3133) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P83455

	MYH6 Antibody (YA3200) MYH6; MYH7; MYHC; MYHCA; MYHCB; myosin heavy chain 6; myosin heavy chain; myosin-6; myosin heavy chain; cardiac muscle alpha isoform	WB, IHC-P	Human, Mouse, Rat
	MYH6 Antibody (YA3200) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3200), targeting MYH6, with a predicted molecular weight of 224 kDa. MYH6 Antibody (YA3200) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P82348

	MYL9 Antibody (YA2093) MLC2; CMH10; MLC-2C; myosin RLC; myosin regulatory light chain 2; smooth muscle isoform; myosin regulatory light chain 9; myosin regulatory light chain MRLC1	WB, IHC-P, IP	Human, Mouse, Rat
	MYL9 Antibody (YA2093) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2093), targeting MYL9, with a predicted molecular weight of 20 kDa (observed band size: 20 kDa). MYL9 Antibody (YA2093) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P82964

	MYL2 Antibody (YA2709) myosin regulatory light chain 2; ventricular/cardiac muscle isoform; MLC-2; MLC-2v	WB, IHC-P, IP	Human, Mouse, Rat
	MYL2 Antibody (YA2709) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2709), targeting MYL2, with a predicted molecular weight of 19 kDa (observed band size: 19 kDa). MYL2 Antibody (YA2709) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P81875

	MYH11 Antibody (YA1620) AAT4; FAA4; MYH11; myosin 11; myosin heavy chain 11; myosin heavy chain smooth muscle isoform; myosin heavy polypeptide 11 smooth muscle; SMHC; SMMHC	WB, IHC-P	Human, Mouse
	MYH11 Antibody (YA1620) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1620), targeting MYH11, with a predicted molecular weight of 227 kDa (observed band size: 250 kDa). MYH11 Antibody (YA1620) can be used for WB, IHC-P experiment in human, mouse background.

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