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Results for "

nontuberculous mycobacteria

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148478
    MMV688845

    (R)-GSK1729177A

    		 DNA/RNA Synthesis Infection
    MMV688845 is a nontuberculous mycobacteria (NTM) RNA polymerase inhibitor with bactericidal activity against Mycobacterium abscessus and anti-tuberculosis efficacy .
    MMV688845
  • HY-B0509
    Amikacin hydrate
    Maximum Cited Publications
    13 Publications Verification

    BAY 41-6551 hydrate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin hydrate
  • HY-B0509B
    Amikacin disulfate
    Maximum Cited Publications
    13 Publications Verification

    BAY 41-6551 disulfate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin disulfate
  • HY-12930
    SPR719
    4 Publications Verification

    VXc-486

    		 Topoisomerase Bacterial Infection
    SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM) .
    SPR719
  • HY-107813
    Amikacin sulfate
    Maximum Cited Publications
    13 Publications Verification

    BAY 41-6551 sulfate

    		 Bacterial Antibiotic Infection Cancer
    Amikacin sulfate (BAY 41-6551 sulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin sulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin sulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin sulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin sulfate
  • HY-161135
    TBAJ-5307

    		Bacterial Infection
    TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria inhibitor that can target the FO-domain of the engine and preventing rotation and proton-translocation. TBAJ-5307 inhibits non-tuberculous mycobacteria in vitro and in vivo .
    TBAJ-5307
  • HY-170519
    K13787

    		Bacterial Infection
    K13787 is an acetohydroxyacid synthase (AHAS) inhibitor with antibacterial activity. K13787 has antibacterial activity against a variety of nontuberculous mycobacteria (NTM) and clarithromycin (CLR) resistant strains .
    K13787
  • HY-172263
    KU13

    		Antibiotic Bacterial Infection
    KU13 is an inhibitor of nontuberculous mycobacteria (NTM). The minimum inhibitory concentrations (MIC) of KU13 against Mycobacterium and E. coli are 0.032-8 μg/mL and 2 μg/mL, respectively. KU13 can be used for research in the field of anti-infection .
    KU13
  • HY-B0509BR
    Amikacin (disulfate) (Standard)

    		Bacterial Antibiotic Infection Cancer
    Amikacin (disulfate) (Standard) is the analytical standard of Amikacin (disulfate). This product is intended for research and analytical applications. Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin-and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria .
    Amikacin (disulfate) (Standard)
  • HY-159899
    DHFR-IN-22

    		Bacterial Antibiotic Dihydrofolate reductase (DHFR)
    DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 μg/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 μg/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections .
    DHFR-IN-22

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