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ocular hypotensive agent

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0191S
    Bimatoprost-d5

    AGN 192024 d5

    		 Prostaglandin Receptor Endocrinology
    Bimatoprost-d5 is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect[1][2].
    Bimatoprost-d5
  • HY-B1035
    Levobunolol hydrochloride
    1 Publications Verification

    l-Bunolol hydrochloride

    		 Adrenergic Receptor Cardiovascular Disease Others
    Levobunolol (l-Bunolol) hydrochloride is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol hydrochloride is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol hydrochloride can be used for glaucoma and superior oblique myokymia (SOM) research .
    Levobunolol hydrochloride
  • HY-125641
    AL-34662

    		5-HT Receptor Adrenergic Receptor Cardiovascular Disease
    AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent .
    AL-34662
  • HY-100543
    Zenidolol

    ICI-118551

    		 Adrenergic Receptor Inflammation/Immunology
    Zenidolol (ICI-118551) is a selective β2 adrenergic receptor antagonist. Zenidolol inhibits β2-, β1- and β3-adrenergic receptor with Ki values of 0.7, 49.5 and 611 nM, respectively. Zenidolol can be used as an ocular hypotensive agent used for ophthalmic disease research .
    Zenidolol
  • HY-130395
    15-Keto latanoprost

    		Prostaglandin Receptor Endocrinology
    15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent .
    15-Keto latanoprost
  • HY-119063
    L-645151

    		Carbonic Anhydrase Others
    L-645151 is a carbonic anhydrase inhibitor with ocular penetration and hypotensive activity. L-645151 lowers the elevated intraocular pressure (IOP) of o-chymotripsinized (o-CT) rabbit eyes. L-645151 is promising for research of an ocular hypotensive agent .
    L-645151
  • HY-B1035A
    Levobunolol

    l-Bunolol

    		 Adrenergic Receptor Others
    Levobunolol (l-Bunolol) is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol can be used for glaucoma and superior oblique myokymia (SOM) research .
    Levobunolol
  • HY-163994
    Ibuterol hydrochloride

    KWD 2058 hydrochloride

    		 Others Others
    Ibuterol (KWD 2058) hydrochloride, a diester of Terbutaline (HY-B0802A), is an orally active, selective and effective β-stimulating agent with lipophilic activities. Ibuterol hydrochloride is also an orally active ocular hypotensive agent. Ibuterol hydrochloride relieves bronchial obstruction in asthma without causing circulatory effects. Ibuterol hydrochloride is proming for rasearch of intraocular hypertension, asthma and bronchitis .
    Ibuterol hydrochloride
  • HY-139121
    15(R)-17-Phenyl trinor Prostaglandin F2α

    15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α

    		 Prostaglandin Receptor Endocrinology
    17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive agent. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hr. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
    15(R)-17-Phenyl trinor Prostaglandin F2α
  • HY-116679
    17-trifluoromethylphenyl trinor Prostaglandin F2α

    17-Trifluoromethylphenyl trinor PGF2α

    		 Prostaglandin Receptor Endocrinology
    A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.
    17-trifluoromethylphenyl trinor Prostaglandin F2α

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