Zenidolol (Synonyms: ICI-118551)

Cat. No.: HY-100543: FAQs
Data Sheet Handling Instructions Technical Support

Zenidolol (ICI-118551) is a selective β2 adrenergic receptor antagonist. Zenidolol inhibits β2-, β1- and β3-adrenergic receptor with K_i values of 0.7, 49.5 and 611 nM, respectively. Zenidolol can be used as an ocular hypotensive agent used for ophthalmic disease research.

For research use only. We do not sell to patients.

Zenidolol Chemical Structure

CAS No. : 72795-26-7

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Zenidolol:

Zenidolol hydrochloride

Other Forms of Zenidolol:

Zenidolol hydrochloride In-stock

36 Publications Citing Use of MCE Zenidolol

: Zenidolol purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2023 Apr 2,19.; Zenidolol (ICI; 10 μM; 2 h) abolishes the Epinephrine-induced phosphorylation of CREB1 in MC38 and HT-29 cells.

: Zenidolol purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118. [Abstract]; PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.

: Zenidolol purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2016 Sep;36(3):1576-84. [Abstract]; Western blotting of Bcl-2 expression in 8505C lysates after in vitro pharmacologic interventions using propranolol and ICI118551 for 24 h. Western blotting of AKT, p-AKT, mTOR, p-mTOR in 8505C lysates after in vitro pharmacologic interventions using propranolol and ICI118551for 24 h.

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	0.003 μM Compound: (rac)-5, ICI-118551	Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting	[PMID: 19245211]

Molecular Weight

277.40

Formula

C₁₇H₂₇NO₂

CAS No.

72795-26-7

SMILES

C[C@@H](NC(C)C)[C@@H](O)COC1=CC=C(C)C2=C1CCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9. [Content Brief]

Zenidolol Related Classifications

Inflammation/Immunology

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zenidolol72795-26-7ICI-118551ICI118551ICI 118551Adrenergic ReceptorBeta Receptorocular hypotensive agenteadenylatecyclasecAMPselectiveInhibitorinhibitorinhibit

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