2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Zenidolol

Zenidolol (ICI-118551) is a selective β2 adrenergic receptor antagonist. Zenidolol inhibits β2-, β1- and β3-adrenergic receptor with Ki values of 0.7, 49.5 and 611 nM, respectively. Zenidolol can be used as an ocular hypotensive agent used for ophthalmic disease research.

For research use only. We do not sell to patients.

Zenidolol Chemical Structure

Zenidolol Chemical Structure

CAS No. : 72795-26-7

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Zenidolol Related Antibodies

Top Publications Citing Use of Products

35 Publications Citing Use of MCE Zenidolol

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    Zenidolol purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2023 Apr 2,19.

    Zenidolol (ICI; 10 μM; 2 h) abolishes the Epinephrine-induced phosphorylation of CREB1 in MC38 and HT-29 cells.

    Zenidolol purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118.  [Abstract]

    PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.

    Zenidolol purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2016 Sep;36(3):1576-84.  [Abstract]

    Western blotting of Bcl-2 expression in 8505C lysates after in vitro pharmacologic interventions using propranolol and ICI118551 for 24 h. Western blotting of AKT, p-AKT, mTOR, p-mTOR in 8505C lysates after in vitro pharmacologic interventions using propranolol and ICI118551for 24 h.

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    Description

    Zenidolol (ICI-118551) is a selective β2 adrenergic receptor antagonist. Zenidolol inhibits β2-, β1- and β3-adrenergic receptor with Ki values of 0.7, 49.5 and 611 nM, respectively. Zenidolol can be used as an ocular hypotensive agent used for ophthalmic disease research[1].

    Cellular Effect
    Cell Line Type Value Description References
    Sf9 IC50
    0.003 μM
    Compound: (rac)-5, ICI-118551
    Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
    Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
    		[PMID: 19245211]
    Molecular Weight

    277.40

    Formula

    C17H27NO2
    CAS No.
    SMILES

    C[C@@H](NC(C)C)[C@@H](O)COC1=CC=C(C)C2=C1CCC2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Zenidolol Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Zenidolol72795-26-7ICI-118551ICI118551ICI 118551Adrenergic ReceptorBeta Receptorocular hypotensive agenteadenylatecyclasecAMPselectiveInhibitorinhibitorinhibit

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