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Results for "

p18 Inhibitor

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Peptides

1

Recombinant Proteins

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123535

    Others Inflammation/Immunology
    P18IN003 is a potent p18(INK4C) inhibitor andspecifically block the activity of p18 protein. P18IN003 has the potential to be aneffective chemical agent for therapeutic expansion of HSC .
    P18IN003
  • HY-100791
    NSC23005 sodium
    1 Publications Verification

    Others Cancer
    NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.
    NSC23005 sodium
  • HY-135809

    Potassium Channel Neurological Disease
    A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K + channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC50=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception .
    A2764 dihydrochloride
  • HY-120942

    Others Cancer
    XIE18-6 is a potent INK4C (p18) inhibitor. XIE18-6 shows potent bioactivity in hematopoietic stem cells (HSCs) expansion with an ED50 of 105.5 nM .
    XIE18-6
  • HY-P4259

    Thrombin Cardiovascular Disease
    Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect .
    Hirullin P18
  • HY-115893A

    Others Cancer
    P18IN005 hydrochloride is a novel inhibitor of p18, exhibiting potent activity in negatively regulating haematopoietic stem cell (HSC) self-renewal. P18IN005 hydrochloride has been shown to be more effective than p27 in inhibiting HSC self-renewal in mouse models. P18IN005 hydrochloride promotes the expansion of functional HSCs in short-term cultures. P18IN005 hydrochloride serves as a valuable tool for dissecting the signaling pathways involved in stem cell self-renewal.
    P18IN005 hydrochloride
  • HY-116923

    Endogenous Metabolite Metabolic Disease
    p18SMI-21 is a novel INK4C inhibitor that specifically blocks the biological activity of p18 protein. p18SMI-21 exerts its anti-gastric acid effect through direct contact, and the intensity of this effect varies with the dose. p18SMI-21 can significantly reduce the proteolytic activity of pepsin under certain conditions. The inhibitory effect of p18SMI-21 is best achieved in direct contact with the substrate. If it contacts the substrate first, the inhibitory effect will be lost .
    p18SMI-21
  • HY-149025

    p18

    Phospholipase Inflammation/Immunology Cancer
    DPTIP-proagent 18 (P18) is a orally active and brain-penetrable proagent of DPTIP (HY-131002). DPTIP-proagent 18 is a potent nSMase2 inhibitor. DPTIP-proagent 18 significantly inhibits IL-1β-induced EV (extracellular vesicle) release by inhibition of nSMase2 (neutral sphingomyelinase-2) activity. DPTIP-proagent 18 can be used for brain injury research .
    DPTIP-prodrug 18
  • HY-144211

    Ras Cancer
    SOS1-IN-7 (compound 18-p1) is a potent SOS1 inhibitor with IC50s of 20 and 67 nM for SOS1-G12D and SOS1-G12V, respectively .
    SOS1-IN-7