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periodontal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Bacterial (6) CMV (1) Drug Metabolite (1) Endogenous Metabolite (3) Glycosidase (1) Histone Demethylase (1) HSV (1) Interleukin Related (1) Melanocortin Receptor (1) MMP (1) Somatostatin Receptor (1) Succinate Receptor 1 (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) VD/VDR (1)
By Research Areas:	Cancer (3) Infection (8) Inflammation/Immunology (7) Metabolic Disease (3) Neurological Disease (2)

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Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150205

Succinate/succinate receptor antagonist 1	Succinate Receptor 1	Inflammation/Immunology
Succinate/succinate receptor antagonist 1 (compound 7a) is a succinate/succinate receptor antagonist. Succinate/succinate receptor antagonist 1 blocks succinate signaling in gingival tissue. Succinate/succinate receptor antagonist 1 inhibits the activation of succinate receptor 1 (SucnRl) with an IC₅₀ value of 20 μΜ. Succinate/succinate receptor antagonist 1 can be used for the research of periodontal disease .

HY-10979

AN0128	Bacterial	Infection Inflammation/Immunology
AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against *S. aureus, S. epidermidis, P. acnes, B. subtilis* with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases .

HY-W749867

Ca(II)-EDTA disodium dihydrate Calcium disodium EDTA dihydrate	Bacterial	Infection Others
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .

HY-N12240

Oleanolic aldehyde	Bacterial	Infection
Oleanolic aldehyde is an antimicrobial compound used to inhibit oral bacteria. Oleanolic aldehyde inhibits Streptococcus mutans and Porphyromonas gingivalis, which are associated with dental caries and periodontal disease, with minimum inhibitory concentrations (MICs) of 488 μg/mL and 250 μg/mL, respectively .

HY-N3345

Macrocarpal B	Bacterial	Infection
Macrocarpal B is an antibacterial compounds. Macrocarpal B can be isolated from the branch of Eucalyptus globulus. Macrocarpal B can be used for the research of periodontal disease .

HY-NP189

Human Immunoglobulin G Human IgG	Bacterial	Infection Inflammation/Immunology
Human Immunoglobulin G (Human IgG) is an immunoglobulin that plays a protective role in humoral immunity by producing antibody responses against specific pathogens (such as Bacteroides forsythus and Prevotella intermedia). Human Immunoglobulin G (Human IgG) can also serve as an antibody standard for quantitative analysis in enzyme-linked immunosorbent assays (ELISA). Human Immunoglobulin G antibody levels can be used for research on rheumatoid arthritis (RA) and periodontal disease .

HY-B0746

Flurbiprofen sodium dl-Flurbiprofen sodium	Endogenous Metabolite	Inflammation/Immunology
Flurbiprofen sodium (dl-Flurbiprofen sodium) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory and analgesic activities. Flurbiprofen sodium is used to reduce bone resorption in periodontal disease, and it works by inhibiting carbonic anhydrase. Flurbiprofen sodium is formulated as biodegradable microspheres for use as a compound delivery system, particularly within the periodontal pocket. The release rate of flurbiprofen sodium is related to the concentration of polymer and polyvinyl alcohol used in its preparation .

HY-B0746R

Flurbiprofen (sodium) (Standard)	Endogenous Metabolite	Inflammation/Immunology
Flurbiprofen (sodium) (Standard) is the analytical standard of Flurbiprofen (sodium). This product is intended for research and analytical applications. Flurbiprofen sodium (dl-Flurbiprofen sodium) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory and analgesic activities. Flurbiprofen sodium is used to reduce bone resorption in periodontal disease, and it works by inhibiting carbonic anhydrase. Flurbiprofen sodium is formulated as biodegradable microspheres for use as a compound delivery system, particularly within the periodontal pocket. The release rate of flurbiprofen sodium is related to the concentration of polymer and polyvinyl alcohol used in its preparation .

HY-164036R

Lolamicin (Standard)	Antibiotic Bacterial	Infection
Flurbiprofen (sodium) (Standard) is the analytical standard of Flurbiprofen (sodium). This product is intended for research and analytical applications. Flurbiprofen sodium (dl-Flurbiprofen sodium) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory and analgesic activities. Flurbiprofen sodium is used to reduce bone resorption in periodontal disease, and it works by inhibiting carbonic anhydrase. Flurbiprofen sodium is formulated as biodegradable microspheres for use as a compound delivery system, particularly within the periodontal pocket. The release rate of flurbiprofen sodium is related to the concentration of polymer and polyvinyl alcohol used in its preparation .

HY-P3567

*(p-Iodo-Phe7)-ACTH (4-10)*	Melanocortin Receptor	Neurological Disease
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats .

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	VD/VDR Drug Metabolite Endogenous Metabolite	Metabolic Disease
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-P2434

AP102	Somatostatin Receptor	Neurological Disease Metabolic Disease Cancer
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC₅₀: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .

HY-123429

CK0683A	Antibiotic	Infection
CK0683A is a novel biaminourea antibiotic with antiplaque effects and demonstrated efficacy in experimental mouse dental disease models. A 12-week study in beagles compared its efficacy in terms of plaque and gingivitis reduction, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease is similar to that of humans. As a positive control for plaque and gingivitis reduction and staining, chlorhexidine acetate was selected because it is effective in both humans and dogs.

HY-123479

CK0492B	Antibiotic	Infection
CK0492B is a novel biaminourea antibiotic that has antiplaque properties in vitro and has shown efficacy in an experimental mouse dental disease model. A 12-week study in beagles compared its efficacy in reducing plaque and gingivitis, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease are similar to humans. Chlorhexidine acetate was selected as a positive control for plaque and gingivitis reduction and staining because it is effective in both humans and dogs.

HY-D1056D

Lipopolysaccharides, from P. gingivalis LPS, from Porphyromonas gingivalis	Toll-like Receptor (TLR)	Inflammation/Immunology
Lipopolysaccharides, from P. gingivalis (LPS, from Porphyromonas gingivalis) are endotoxins and TLR4 activators extracted from Porphyromonas gingivalis (P. gingivalis) and are classified as S (smooth) type LPS. Lipopolysaccharides, from P. gingivalis possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from P. gingivalis activate TLR-4 in immune cells and are important virulence factors in the mechanism of periodontal disease. *Lipopolysaccharides, from P. gingivalis* can be used in research related to periodontitis** .

HY-N1940

β-Anhydroicaritin 1 Publications Verification Cycloicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology Cancer
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-N0946

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Glycosidase	Metabolic Disease
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

HY-12725

ML324 Maximum Cited Publications 6 Publications Verification	Histone Demethylase HSV CMV	Cancer
ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC₅₀ of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression .

Cat. No.	Product Name	Type

HY-W749867

Ca(II)-EDTA disodium dihydrate Calcium disodium EDTA dihydrate	Chelators
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .

HY-NP189

Human Immunoglobulin G Human IgG	Native Proteins
Human Immunoglobulin G (Human IgG) is an immunoglobulin that plays a protective role in humoral immunity by producing antibody responses against specific pathogens (such as Bacteroides forsythus and Prevotella intermedia). Human Immunoglobulin G (Human IgG) can also serve as an antibody standard for quantitative analysis in enzyme-linked immunosorbent assays (ELISA). Human Immunoglobulin G antibody levels can be used for research on rheumatoid arthritis (RA) and periodontal disease .

Human Immunoglobulin G

Human IgG

Native Proteins

Human Immunoglobulin G (Human IgG) is an immunoglobulin that plays a protective role in humoral immunity by producing antibody responses against specific pathogens (such as Bacteroides forsythus and Prevotella intermedia). Human Immunoglobulin G (Human IgG) can also serve as an antibody standard for quantitative analysis in enzyme-linked immunosorbent assays (ELISA). Human Immunoglobulin G antibody levels can be used for research on rheumatoid arthritis (RA) and periodontal disease .

HY-D1056D

Lipopolysaccharides, from P. gingivalis LPS, from Porphyromonas gingivalis	Carbohydrates
Lipopolysaccharides, from P. gingivalis (LPS, from Porphyromonas gingivalis) are endotoxins and TLR4 activators extracted from Porphyromonas gingivalis (P. gingivalis) and are classified as S (smooth) type LPS. Lipopolysaccharides, from P. gingivalis possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from P. gingivalis activate TLR-4 in immune cells and are important virulence factors in the mechanism of periodontal disease. *Lipopolysaccharides, from P. gingivalis* can be used in research related to periodontitis** .

Lipopolysaccharides, from P. gingivalis

LPS, from Porphyromonas gingivalis

Carbohydrates

Lipopolysaccharides, from P. gingivalis (LPS, from Porphyromonas gingivalis) are endotoxins and TLR4 activators extracted from Porphyromonas gingivalis (P. gingivalis) and are classified as S (smooth) type LPS. Lipopolysaccharides, from P. gingivalis possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from P. gingivalis activate TLR-4 in immune cells and are important virulence factors in the mechanism of periodontal disease. Lipopolysaccharides, from P. gingivalis can be used in research related to periodontitis .

Cat. No.	Product Name	Target	Research Area

HY-P3567

*(p-Iodo-Phe7)-ACTH (4-10)*	Melanocortin Receptor	Neurological Disease
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats .

HY-P2434

AP102	Somatostatin Receptor	Neurological Disease Metabolic Disease Cancer
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC₅₀: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .

Oleanolic aldehyde	Triterpenes Structural Classification Terpenoids Source classification Vitis vinifera cv. Zalema Plants Vitaceae	Bacterial
Oleanolic aldehyde is an antimicrobial compound used to inhibit oral bacteria. Oleanolic aldehyde inhibits Streptococcus mutans and Porphyromonas gingivalis, which are associated with dental caries and periodontal disease, with minimum inhibitory concentrations (MICs) of 488 μg/mL and 250 μg/mL, respectively .

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	VD/VDR Drug Metabolite Endogenous Metabolite
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

β-Anhydroicaritin 1 Publications Verification Cycloicaritin	Flavonols Structural Classification Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

Macrocarpal B	Eucalyptus macrocarpa Hook. Terpenoids Sesquiterpenes Myrtaceae Plants	Bacterial
Macrocarpal B is an antibacterial compounds. Macrocarpal B can be isolated from the branch of Eucalyptus globulus. Macrocarpal B can be used for the research of periodontal disease .

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Structural Classification Artemisia selengensis Turcz. ex Bess. Source classification Plants Compositae Saccharides Monosaccharides	Glycosidase
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

Cat. No.	Compare	Product Name	Species	Source

HY-P72093

	ASPN Protein, Human (His-SUMO) ASPN; ASPN protein; ASPN_HUMAN; Asporin LRR class 1; ; Asporin; Asporin proteoglycan; FLJ20129; LRR class 1; periodontal ligament associated protein 1; periodontal ligament-associated protein 1; PLAP 1; PLAP-1; PLAP1; SLRR 1C; SLRR1C; Small leucine rich protein 1C	Human	E. coli
	ASPN protein acts as a negative regulator in periodontal ligament (PDL) differentiation and mineralization, preventing ossification and maintaining homeostasis of the tooth support system. It inhibits BMP2-induced cell differentiation by blocking the binding of BMP2 to BMPR1B, thereby preventing BMP-dependent activation of SMAD proteins. ASPN Protein, Human (His-SUMO) is the recombinant human-derived ASPN protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of ASPN Protein, Human (His-SUMO) is 348 a.a., with molecular weight of 55-60 kDa.

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