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Results for "

preventive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adiponectin Receptor (1) AMPK (1) Amyloid-β (1) Androgen Receptor (2) Bacterial (1) COMT (1) COX (3) Dipeptidyl Peptidase (1) Drug Metabolite (1) Endogenous Metabolite (6) Glutathione Peroxidase (1) Glutathione S-transferase (1) Glycosidase (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (2) Monoamine Oxidase (1) NF-κB (2) NO Synthase (1) PGC-1α (1) Phosphodiesterase (PDE) (1) Phospholipase (1) PPAR (1) Reactive Oxygen Species (2) SARS-CoV (1) Sirtuin (1) TNF Receptor (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (9) Metabolic Disease (6) Neurological Disease (6)

By Targets:

5-HT Receptor (4)

Adiponectin Receptor (1)

AMPK (1)

Amyloid-β (1)

Androgen Receptor (2)

Bacterial (1)

COMT (1)

COX (3)

Dipeptidyl Peptidase (1)

Drug Metabolite (1)

Endogenous Metabolite (6)

Glutathione Peroxidase (1)

Glutathione S-transferase (1)

Glycosidase (1)

Isotope-Labeled Compounds (1)

Mitochondrial Metabolism (2)

Monoamine Oxidase (1)

NF-κB (2)

NO Synthase (1)

PGC-1α (1)

Phosphodiesterase (PDE) (1)

Phospholipase (1)

PPAR (1)

Reactive Oxygen Species (2)

SARS-CoV (1)

Sirtuin (1)

TNF Receptor (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (4)

Infection (1)

Inflammation/Immunology (9)

Metabolic Disease (6)

Neurological Disease (6)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101698B

Alniditan dihydrochloride Alnitidan dihydrochloride	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alniditan (Alnitidan) dihydrochloride is a potent 5-HT_1B and 5-HT_1D receptors agonist, with IC₅₀s of 1.7 nM and 1.3 nM for h5-HT_1B and h5-HT_1D receptors in HEK?293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects .

HY-N0522

(-)-Gallocatechin gallate 2 Publications Verification (-)-Gallocatechol gallate	COMT	Cancer
(-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities.

HY-N0679

Retinyl acetate 2 Publications Verification Retinol acetate; Vitamin A acetate	Others	Cancer
Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .

HY-N3009

Secoxyloganin	Others	Cardiovascular Disease
Secoxyloganin, isolated from Lonicera japonica Thunb, inhibits the blood flow (BF) decrease. Secoxyloganin has allergy-preventive activity .

HY-101698

Alniditan Alnitidan	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alniditan (Alnitidan) is a potent 5-HT_1B and 5-HT_1D receptors agonist, with IC₅₀s of 1.7 nM and 1.3 nM for h5-HT_1B and h5-HT_1D receptors in HEK 293 cells, respectively. Alniditan has migraine-preventive effects .

HY-163332

MPO-IN-6	Glycosidase Dipeptidyl Peptidase Glutathione Peroxidase	Cardiovascular Disease
MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC₅₀s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent .

HY-165027

DL-1′-Acetoxychavicol acetate	NO Synthase COX	Others
DL-1′-Acetoxychavicol acetate is a compound with anti-inflammatory and anticancer preventive potential that inhibits the activities of NOX, iNOS, and COX-2 in inflammatory cells and exhibits preventive activity in multiple inflammation-related cancer models.

HY-N8690

4,2'-Dihydroxy-4'-methoxychalcone	Others	Inflammation/Immunology
4,2'-Dihydroxy-4'-methoxychalcone, a chalcone, shows allergy-preventive effects .

HY-119657

Cellocidin	Bacterial	Others
Cellocidin is an agricultural antibiotic with preventive effects against rice bacterial leaf blight and is thought to work by inhibiting the α-ketoglutarate-succinate system in Xanthomonas sp.

HY-N0522R

(-)-Gallocatechin gallate (Standard)	Others	Cancer
(-)-Gallocatechin gallate (Standard) is the analytical standard of (-)-Gallocatechin gallate. This product is intended for research and analytical applications. (-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities.

HY-N0679R

Retinyl acetate (Standard)	Others	Cancer
Retinyl acetate (Standard) is the analytical standard of Retinyl acetate. This product is intended for research and analytical applications. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities .

HY-106328

Fluasterone	Mitochondrial Metabolism	Metabolic Disease Inflammation/Immunology Cancer
Fluasterone is a potent G6PD inhibitor with a K_i of 0.51 μM. Fluasterone has anti-inflammatory, cancer preventive, and anti-diabetic effects. Fluasterone is orally active .

HY-116726

Crambene	Glutathione S-transferase	Cancer
Crambene is an orally active cyanide compound isolated from cruciferous vegetables. Crambene has a cancer-preventive effect and induces significant upregulation of quinone reductase and glutathione S-transferase in vitro and in vivo .

HY-N0679S4

Retinyl acetate-d4 Retinol acetate-d₄; Vitamin A acetate-d₄	Isotope-Labeled Compounds	Cancer
Retinyl acetate-d₄ is the deuterium labeled Retinyl acetate[1]. Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities[2].

HY-N2419

Erythrodiol	Endogenous Metabolite	Metabolic Disease
Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis .

HY-N3009R

Secoxyloganin (Standard)	Others	Cardiovascular Disease
Secoxyloganin (Standard) is the analytical standard of Secoxyloganin. This product is intended for research and analytical applications. Secoxyloganin, isolated from Lonicera japonica Thunb, inhibits the blood flow (BF) decrease. Secoxyloganin has allergy-preventive activity .

HY-N6057

Obtusin	Monoamine Oxidase	Neurological Disease
Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC₅₀ of 11.12 μM and a K_i of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression .

HY-116266

RS 67333	5-HT Receptor	Others
RS 67333 is a 5-HT4R agonist with stress-preventive activity. RS 67333 attenuates stress-induced body weight changes and prevents depression- and anxiety-like behaviors in two mouse strains tested in different stress models.

HY-N2419R

Erythrodiol (Standard)	Endogenous Metabolite	Metabolic Disease
Erythrodiol (Standard) is the analytical standard of Erythrodiol. This product is intended for research and analytical applications. Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis .

HY-114766

Pumafentrine	Phosphodiesterase (PDE)	Inflammation/Immunology
Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFα production in murine Dextran sulphate sodium (DSS; HY-116282C)-induced colitis in a preventive setting .

HY-159910

LH1513	Mitochondrial Metabolism	Cancer
LH1513 is a dioxalate derivative of l-lysine (HY-N0469) that inhibits CaOx crystallization with better activity than citrate and pyruvate. LH1513 has potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolism .

HY-130479

AdipoR agonist 1	Adiponectin Receptor PPAR PGC-1α Sirtuin AMPK	Metabolic Disease
AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research .

HY-146435

Anti-inflammatory agent 22	TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 22 (compound 14a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 22 inhibits LPS-induced TNF-α production with an IC₅₀ value of 14.6 μM. Anti-inflammatory agent 22 has preventive effects on lymphedematous tissue via suppression of adipogenesis. Anti-inflammatory agent 22 suppresses limb lymphedema volume in mice .

HY-116807

Dihydrolipoic Acid 1 Publications Verification DHLA	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .

HY-N12708

23-O-β-D-Glucopyranosyl-20-isoveratramine	Others	Others
23-O-β-D-Glucopyranosyl-20-isoveratramine is a potential anti-allergic agent extracted from nettles. A variety of COX-1, COX-2, 5-lipoxygenase and trypsin-like inhibitors and H1 antagonists are found in nettle extract, which can inhibit seasonal allergies, allergic rhinitis and other inflammatory diseases. and preventive effects .

HY-W040235

Fluazuron	Endogenous Metabolite	Others
Fluazuron is an insect growth regulator with activity against larvae of Amblyomma sculptum. Fluazuron exhibits 100% efficacy by interfering with the molting process. Fluazuron has shown rapid absorption and slow metabolism in experiments. The use of Fluazuron offers a potential preventive measure for the control of Brazilian spotted fever. The results of Fluazuron offer good prospects for the development of feed products containing FLU to control ticks in free-living capybaras .

HY-B0019

Azasetron (Rac)-SENS-401 free base	5-HT Receptor	Neurological Disease
Azasetron ((Rac)-SENS-401 free base) is an antiemetic drug with 5-HT3 receptor antagonist activity. Azasetron is often used as a preventive measure for postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting. Azasetron does not impair neutrophil chemotaxis or phagocytosis and does not scavenge O(-)(2) or H(2)O(2) generated by cell-free systems .

HY-145644

Ogalvibart C-135-LS; BMS-986414	SARS-CoV	Infection Cancer
Ogalvibart (C-135-LS) is a human anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Ogalvibart binds to the spike (S) glycoprotein receptor-binding domain (RBD) of SARS-CoV-2. Ogalvibart in combination with C144LS (1:1 ratio) shows good preventive activity and can effectively block the development of COVID19 in a rhesus monkey disease model .

HY-116807R

Dihydrolipoic Acid (Standard)	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Dihydrolipoic Acid (Standard) is the analytical standard of Dihydrolipoic Acid. This product is intended for research and analytical applications. Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .

HY-N6660

Trisdecanoin Tricaprin; Glyceryl tridecanoate	Endogenous Metabolite Androgen Receptor	Cardiovascular Disease Metabolic Disease
Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .

HY-120050

GK470	Phospholipase	Inflammation/Immunology
GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA₂) with an IC₅₀ of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC₅₀ value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE₂ levels .

HY-N0256

Hederagenin 3 Publications Verification	COX NF-κB	Cancer
Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

HY-N6660R

Trisdecanoin (Standard)	Endogenous Metabolite Androgen Receptor	Metabolic Disease
Trisdecanoin (Standard) is the analytical standard of Trisdecanoin. This product is intended for research and analytical applications. Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .

HY-N0256R

Hederagenin (Standard)	COX NF-κB	Cancer
Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

HY-113327R

1,3,7-Trimethyluric acid (Standard)	Drug Metabolite Endogenous Metabolite	Cancer
Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

HY-118243

KMS88009	Amyloid-β	Others
KMS88009 is a potent small molecule that directly interferes with the formation of amyloid-β oligomers, thereby preserving cognitive behavior when used preventively and reversing cognitive behavior decline when used therapeutically. Oral administration of KMS88009 around the onset of Alzheimer's disease symptoms significantly reduced the assembly of amyloid-β oligomers and improved cognitive behavior in the APP/PS1 double transgenic mouse model. This unique dual mode of action suggests that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. In an evaluation, the physicochemical properties, pharmacokinetics and toxicity of this anti-amyloidogenic small molecule KMS88009 were studied, as well as post-mortem analysis of APP/PS1 TG mice after behavioral testing.

Cat. No.	Product Name	Target	Research Area