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Results for "

reinstatement

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N6960
    L-Stepholidine

    Stepholidine; (-)-Stepholidine; L-SPD

    		 Dopamine Receptor Neurological Disease
    L-Stepholidine (Stepholidine) exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction .
    L-Stepholidine
  • HY-145196
    RTICBM-189

    		Cannabinoid Receptor Neurological Disease
    RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca 2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats .
    RTICBM-189
  • HY-12443
    PF-5006739

    		Casein Kinase Neurological Disease
    PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner . PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity .
    PF-5006739
  • HY-159624
    KK-92A

    		GABA Receptor Neurological Disease
    KK-92A, a blood-brain barrier penetrated GABAB positive allosteric modulator (PAM), suppresses alcohol self-administration and cue-induced reinstatement of alcohol seeking in rats .
    KK-92A
  • HY-119277
    CJB-090 dihydrochloride

    		Dopamine Receptor Neurological Disease
    CJB-090 dihydrochloride is a partial agonist with activity at dopamine D3 receptors. CJB-090 exhibits partial agonist characteristics in vitro. CJB-090 elicits yawning responses only in monkeys with an extensive history of cocaine use. CJB-090 reduces the reinstatement effects of cocaine in reinstatement behaviors induced by cocaine .
    CJB-090 dihydrochloride
  • HY-134912
    CMPPE

    		GABA Receptor Neurological Disease
    CMPPE is a GABAB receptor positive allosteric modulator (PAM) that inhibits alcohol self-administration and reinstatement behavior in rats .
    CMPPE
  • HY-W634602
    (R)-RO5263397

    		Trace Amine-associated Receptor (TAAR) Others
    (R)-RO5263397 is a TAAR 1 agonist that demonstrates efficacy in reducing cocaine-mediated behaviors, including cocaine-induced behavioral sensitization, cue- and cocaine prime-induced reinstatement of cocaine-seeking behavior, and the expression of conditioned place preference.
    (R)-RO5263397
  • HY-12697A
    NGB 2904 hydrochloride

    		Dopamine Receptor Neurological Disease
    NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole-stimulated mitogenesis .
    NGB 2904 hydrochloride
  • HY-161665
    BDZ-P7

    		iGluR Neurological Disease
    BDZ-P7 inhibits AMPA receptor GluA2, GluA1/2, GluA2/3, and GluA1 subunit with IC50s of 3.03 μM, 3.14 μM, 3.19 μM, 3.2 μM. BDZ-P7 has neuroprotective effect and reinstates locomotor abilities in a mouse model of Parkinson’s disease .
    BDZ-P7
  • HY-162872
    NBI-35965

    		CRFR Neurological Disease
    NBI-35965 is an antagonist of corticotropin-releasing factor receptor 1 (CRF-R1). NBI-35965 can be used in nervous system related research .
    NBI-35965

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