2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. L-Stepholidine

L-Stepholidine  (Synonyms: Stepholidine; (-)-Stepholidine; L-SPD)

Cat. No.: HY-N6960 Purity: 99.79%
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L-Stepholidine (Stepholidine) exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction.

For research use only. We do not sell to patients.

L-Stepholidine Chemical Structure

L-Stepholidine Chemical Structure

CAS No. : 16562-13-3

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1 mg USD 220 In-stock
5 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

L-Stepholidine Related Antibodies

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Description

L-Stepholidine (Stepholidine) exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction[1][2][3].

IC50 & Target

Dopamine D1 receptor[1]
Dopamine D2 receptor[1]
Cellular Effect
Cell Line Type Value Description References
THP-1 IC50
104.58 nM
Compound: 8, l-SPD
Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs
Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs
[PMID: 23199480]
Molecular Weight

327.37

Formula

C19H21NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(OC)C=C(CCN2CC3=C(OC)C(O)=CC=C3C[C@]24[H])C4=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (305.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0546 mL 15.2732 mL 30.5465 mL
5 mM 0.6109 mL 3.0546 mL 6.1093 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0546 mL 15.2732 mL 30.5465 mL 76.3662 mL
5 mM 0.6109 mL 3.0546 mL 6.1093 mL 15.2732 mL
10 mM 0.3055 mL 1.5273 mL 3.0546 mL 7.6366 mL
15 mM 0.2036 mL 1.0182 mL 2.0364 mL 5.0911 mL
20 mM 0.1527 mL 0.7637 mL 1.5273 mL 3.8183 mL
25 mM 0.1222 mL 0.6109 mL 1.2219 mL 3.0546 mL
30 mM 0.1018 mL 0.5091 mL 1.0182 mL 2.5455 mL
40 mM 0.0764 mL 0.3818 mL 0.7637 mL 1.9092 mL
50 mM 0.0611 mL 0.3055 mL 0.6109 mL 1.5273 mL
60 mM 0.0509 mL 0.2546 mL 0.5091 mL 1.2728 mL
80 mM 0.0382 mL 0.1909 mL 0.3818 mL 0.9546 mL
100 mM 0.0305 mL 0.1527 mL 0.3055 mL 0.7637 mL
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L-Stepholidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Stepholidine16562-13-3Stepholidine (-)-Stepholidine L-SPDDopamine ReceptordopamineD1D2neuroprotectiveheroinopiateInhibitorinhibitorinhibit

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