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serum metabolite

" in MedChemExpress (MCE) Product Catalog:

31

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5

Biochemical Assay Reagents

1

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8

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2

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113283
    Homogentisic acid

    		Endogenous Metabolite Metabolic Disease
    Homogentisic acid is a specific metabolite in urine and serum, which is used for diagnosis of alkaptonuria.
    Homogentisic acid
  • HY-137851
    S-Pyruvylglutathione

    		Drug Metabolite Others
    S-Pyruvylglutathione is a serum metabolite and can be used as a potential marker for sensitivity of gastric cancer to neoadjuvant chemotherapy .
    S-Pyruvylglutathione
  • HY-141749A
    Clopidogrel carboxylic acid

    CLPM; SR 26334

    		 Endogenous Metabolite Metabolic Disease
    Clopidogrel carboxylic acid (CLPM) is the inactive liver metabolite of anti platelet agent, Clopidogrel (HY-15283), in human serum .
    Clopidogrel carboxylic acid
  • HY-W011297
    Methyl arachidonate

    Arachidonic acid methyl ester

    		 Biochemical Assay Reagents Metabolic Disease
    Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
    Methyl arachidonate
  • HY-148002
    1'-Hydroxy Midazolam-β-D-glucuronide

    		Drug Metabolite Others
    1'-Hydroxy Midazolam-β-D-glucuronide is a β-D-glucuronide that acts as a drug metabolite, human urine metabolite, and human serum metabolite .
    1'-Hydroxy Midazolam-β-D-glucuronide
  • HY-NP002D
    Bovine Serum Albumin (Biotinylated)

    		Biochemical Assay Reagents Others
    Bovine Serum Albumin (Biotinylated) is a biotinylated bovine serum albumin that selectively binds to different vascular subsets in lymphoid tissue. Serum albumin is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules .
    Bovine Serum Albumin (Biotinylated)
  • HY-NP002B
    Rabbit Serum Albumin

    		Biochemical Assay Reagents Others
    Rabbit Serum Albumin is a plasma protein derived from rabbits. Serum albumin is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules .
    Rabbit Serum Albumin
  • HY-NP002A
    Goat Serum Albumin

    		Biochemical Assay Reagents Others
    Goat Serum Albumin is a plasma protein derived from goats. Serum albumin is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules .
    Goat Serum Albumin
  • HY-NP002I
    Sheep Serum Albumin

    		Biochemical Assay Reagents Others
    Sheep Serum Albumin is a plasma protein derived from sheep. Serum albumin is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules .
    Sheep Serum Albumin
  • HY-NP002C
    Rabbit Serum Albumin (globulin free)

    		Biochemical Assay Reagents Others
    Rabbit Serum Albumin (globulin free) is a plasma protein derived from rabbits. Serum albumin is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules .
    Rabbit Serum Albumin (globulin free)
  • HY-W775325
    7-Hydroxycannabidiol

    7-OH-CBD

    		 Drug Metabolite Neurological Disease
    7-Hydroxycannabidiol (7-OH-CBD) is the metabolite of cannabidiol, which could be found in human serum and saliva .
    7-Hydroxycannabidiol
  • HY-W005178
    Octadecanedioic acid

    		Endogenous Metabolite Others
    Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome .
    Octadecanedioic acid
  • HY-154918
    LysoPE(18:2/0:0)

    		Drug Metabolite Metabolic Disease
    LysoPE(18:2/0:0) is a serum metabolite and a potential biomarker for the combined toxicity of DEHP and Aroclor 1254 .
    LysoPE(18:2/0:0)
  • HY-113283R
    Homogentisic acid (Standard)

    		Endogenous Metabolite Metabolic Disease
    Homogentisic acid (Standard) is the analytical standard of Homogentisic acid. This product is intended for research and analytical applications. Homogentisic acid is a specific metabolite in urine and serum, which is used for diagnosis of alkaptonuria.
    Homogentisic acid (Standard)
  • HY-129431
    U-89843A

    		Drug Intermediate Others
    U-89843A is a precursor of U-97924 and forms U-97924 as the major metabolite. Although U-97924 showed mutagenic potential in rat hepatocytes in a serum-free in vitro assay, no genotoxicity of U-97924 was observed in rats at high oral doses. Rat serum also inhibited the in vitro metabolism of U-89843 and the formation of the corresponding hydroxylated metabolite, U-97924 .
    U-89843A
  • HY-120164
    Glycerophospho-N-oleoyl ethanolamine

    GNOE

    		 Endogenous Metabolite Cardiovascular Disease
    Glycerophospho-N-oleoyl ethanolamine (GNOE) is a serum metabolite. Glycerophospho-N-oleoyl ethanolamine can be used to study Bicuspid aortic valve (BAV) disease .
    Glycerophospho-N-oleoyl ethanolamine
  • HY-124041
    p-Hydroxybestatin

    		Drug Metabolite
    p-Hydroxybestatin is an active metabolite of Bestatinc (HY-B0134) that can be found in serum from muscular dystrophic patients and from healthy subjects dosed with Bestatin .
    p-Hydroxybestatin
  • HY-145521
    5(S)-HETrE

    5(S)-Hydroxy-6E,8Z,11Z-eicosatrienoic acid

    		 Endogenous Metabolite Cardiovascular Disease
    5(S)-HETrE is a metabolite of the ω-6 fatty acid γ-linolenic acid. 5(S)-HETrE can be elevated in serum levels in an obesity mouse model .
    5(S)-HETrE
  • HY-W017445
    Homogentisic acid lactone

    		Fungal Infection
    Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .
    Homogentisic acid lactone
  • HY-W011297S3
    Methyl arachidonate-13C5

    Arachidonic acid methyl ester-13C5

    		 Isotope-Labeled Compounds Others Metabolic Disease
    Methyl arachidonate- 13C5 (Arachidonic acid methyl ester- 13C5) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
    Methyl arachidonate-13C5
  • HY-W011297S2
    Methyl arachidonate-13C4

    Arachidonic acid methyl ester-13C4

    		 Isotope-Labeled Compounds Others Metabolic Disease
    Methyl arachidonate- 13C4 (Arachidonic acid methyl ester- 13C4) is 13C labeled Methyl arachidonate. Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
    Methyl arachidonate-13C4
  • HY-116870
    Vamidothion

    		Parasite Infection
    Vamidothion is a polar organophosphorus insecticide and acaricide with biological activity against insects and mites. Vamidothion is degraded by human serum albumin (HSA) and promotes adduct formation with tyrosine residues. The phosphate amino acid adducts formed after the reaction of vamidothion with HSA are detected by liquid chromatography quadrupole-Orbitrap mass spectrometry. The metabolites of vamidothion can be used in forensic toxicology to help determine deaths caused by organophosphorus poisoning .
    Vamidothion
  • HY-B1986
    p,p'-DDE

    4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene

    		 Androgen Receptor Drug Metabolite Metabolic Disease Endocrinology
    p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women .
    p,p'-DDE
  • HY-160917
    BAY-43-9695

    		CMV Infection
    BAY-43-9695 is a nonnucleosidic with activity against human cytomegalovirus (hCMV) with IC50 of 0.95 and 1.1 μM, using the FACS and PRA methodes. BAY-43-9695 inhibits the HCMV replication with and without presence of serum proteins, with IC50 of 0.53 and 8.42 μM. BAY-43-9695 is the metabolite of Tomeglovir (BAY38-4766) (HY-108261) .
    BAY-43-9695
  • HY-164526
    SH1573

    		Isocitrate Dehydrogenase (IDH) Cancer
    SH1573 is an orally active mIDH2 inhibitor. SH1573 has a strong and selective inhibitory effect on mIDH2 R140Q protein (IC50=4.78 nmol/L), and can effectively reduce the production of the carcinogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum and tumors. SH1573 can be used for the study of acute myeloid leukemia (AML) .
    SH1573
  • HY-N0407
    Picroside I

    6'-Cinnamoylcatalpol

    		 STAT Inflammation/Immunology
    Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .
    Picroside I
  • HY-B1986R
    p,p'-DDE (Standard)

    		Androgen Receptor Drug Metabolite Metabolic Disease Endocrinology
    p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women .
    p,p'-DDE (Standard)
  • HY-N0407R
    Picroside I (Standard)

    		STAT Inflammation/Immunology
    Picroside I (Standard) is the analytical standard of Picroside I. This product is intended for research and analytical applications. Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .
    Picroside I (Standard)
  • HY-135541
    Darexaban maleate

    YM150 maleate

    		 Endogenous Metabolite Cardiovascular Disease
    Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9 .
    Darexaban maleate
  • HY-113513
    5-HEPE

    		Others Cancer
    5(S)-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.
    5-HEPE
  • HY-138089
    17β-Hydroxy exemestane

    		Androgen Receptor Estrogen Receptor/ERR LDLR Metabolic Disease Cancer
    17β-Hydroxy exemestane (17-H-EXE) is the primary active metabolite of Exemestane (HY-13632). 17β-Hydroxy exemestane is an aromatase inhibitor (IC50 = 69 nM) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). 17β-Hydroxy exemestane stimulates growth of AR- and ERα-positive MCF-7 (EC50= 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7 cells. 17β-Hydroxy exemestane inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae in ovariectomized rats .
    17β-Hydroxy exemestane

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