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Results for "

sterol synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (2) Autophagy (6) Cytochrome P450 (2) Endogenous Metabolite (1) Ferroptosis (3) Fungal (5) HMG-CoA Reductase (HMGCR) (6) Isotope-Labeled Compounds (3) NF-κB (1) Parasite (1) Potassium Channel (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (6) Endocrinology (1) Infection (7) Metabolic Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128033

Fenpropimorph	Fungal	Infection
Fenpropimorph is a fungicide that inhibits the sterol pathway. Fenpropimorph inhibits δ8-δ7-sterol isomerase in yeast at low concentrations, with δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol. Fenpropimorph also inhibits sterol synthesis in certain plants and mammalian cells .

HY-N2221

Ganoderal A	Others	Metabolic Disease
Ganoderal A, an oxygenated sterol from G. lucidum, is a cholesterol synthesis inhibitor .

HY-17396

Butenafine Hydrochloride 1 Publications Verification KP363 Hydrochloride	Fungal Antibiotic	Infection
Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-B0165A

Pravastatin sodium 5 Publications Verification CS-514 sodium	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-B0165AR

Pravastatin sodium (Standard) 4 Publications Verification CS-514 sodium (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Pravastatin (sodium) (Standard) is the analytical standard of Pravastatin (sodium). This product is intended for research and analytical applications. Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-128033R

Fenpropimorph (Standard)	Fungal	Infection
Fenpropimorph (Standard) is the analytical standard of Fenpropimorph. This product is intended for research and analytical applications. Fenpropimorph is a fungicide that inhibits the sterol pathway. Fenpropimorph inhibits δ8-δ7-sterol isomerase in yeast at low concentrations, with δ14-sterol reductase being blocked at higher levels, preventing the biosynthesis of ergosterol. Fenpropimorph also inhibits sterol synthesis in certain plants and mammalian cells .

HY-114296

2,3-Oxidosqualene Squalene oxide	Others	Others
2,3-Oxidosqualene (Squalene oxide) is an intermediate in the biological synthesis of sterols from squalene .

HY-B0165

Pravastatin CS-514	Autophagy HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Cancer
Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM .

HY-130752

VNI	Cytochrome P450 Parasite	Infection
VNI is an effective inhibitor of CYP51. VNI can inhibit sterol synthesis in Trypanosoma cruzi, exhibiting anti-Trypanosoma cruzi activity .

HY-17396S

Butenafine-13C,d3 hydrochloride KP363-¹³C,d₃ hydrochloride	Isotope-Labeled Compounds Fungal Antibiotic	Infection
Butenafine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-B0165CS

Pravastatin-d3 sodium salt	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease
Pravastatin-d₃ (sodium) is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1][2].

HY-B0165AS

Pravastatin-13C,d3 sodium CS-514-¹³C,d₃ sodium	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Pravastatin- ¹³C,d₃ (sodium) is the ¹³C- and deuterium labeled Pravastatin (sodium). Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.

HY-B0165S

Pravastatin-d9 sodium CS-514-d₉ sodium	Autophagy HMG-CoA Reductase (HMGCR) Isotope-Labeled Compounds	Cardiovascular Disease Cancer
Pravastatin-d₉ sodium is deuterated labeled Pravastatin (HY-B0165). Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM .

HY-W749520

Zymosterone	Others	Metabolic Disease
Zymosterone is converted into zymosterol, an intermediate in cholesterol synthesis, through the action of the enzyme hydroxysteroid (17β) dehydrogenase 7 (HSD17B7), and this transformation, catalyzed by 3-keto sterol reductase (ERG27), plays a crucial role in the biosynthesis of ergosterol in yeast.

HY-16620

DF 461	Others	Metabolic Disease
DF 461 is a sterol synthase inhibitor with significant inhibitory activity. DF 461 shows high selectivity for the liver and can effectively inhibit cholesterol synthesis in rat liver. DF 461 has shown the effect of lowering plasma lipids in repeated dosing studies in non-rodents .

HY-125400

Zaragozic acid C L-697350	Endogenous Metabolite	Cancer
Zaragozic acid C (L-697350) is a potent sterol synthase inhibitor with potential antitumor activity. Zaragozic acid C contains multiple hydroxyl and alkyl substituents in its chemical structure, demonstrating complex functionalization capabilities. The synthesis of zaragozic acid C involves a photochemical C(sp3)-H acylation reaction, which resolves the challenging carbon substitution problem in the synthesis .

HY-118843

Lombazole	Potassium Channel	Infection
Lombazole is an antimicrobial compound with activity that inhibits cell membrane synthesis. Lombazole had little effect on K+ permeability in S. aureus. Lombazole inhibited only de novo synthesis of cell enclosure in S. aureus, and this effect occurred before growth was affected. The main effect of lombazole was through inhibition of lipid synthesis. Lombazole may have an effect on key steps in lipid biosynthesis, as inferred from the lack of changes in lipid patterns after treatment. Lombazole also inhibited the sterol C-14 demethylation step in Candida albicans .

HY-W422288

(Rac)-Ketoconazole (Rac)-Ketoconazol; (Rac)-R 41400	Fungal Cytochrome P450	Infection
(Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections .

HY-117219

SKF 104976	Others	Metabolic Disease
SKF 104976 is a 3,2-carboxylic acid derivative with potent 14-alpha-demethylase (14 alpha DM) inhibitory activity. SKF 104976 inhibited 14 alpha DM activity by 50% at 2 nM in Hep G2 cell extracts. SKF 104976 inhibited the incorporation of [14C]acetate into cholesterol in intact cells at similar concentrations, accompanied by accumulation of lanosterol, and resulted in a 40-70% decrease in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity. SKF 104976 did not affect the uptake and degradation of low-density lipoprotein in Hep G2 cells, indicating that HMGR and low-density lipoprotein receptor activities are not coordinately regulated under these conditions. The inhibitory effect of SKF 104976 on HMGR activity remained unchanged even when the flux of carbon units in the sterol synthesis pathway was reduced by 80%. SKF 104976 did not inhibit HMGR activity under conditions where sterol synthesis was almost completely blocked by lovastatin .

HY-121012

(rac)-AG-205	NF-κB Akt	Endocrinology
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2221

Ganoderal A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Metabolic Disease Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields	Others
Ganoderal A, an oxygenated sterol from G. lucidum, is a cholesterol synthesis inhibitor .

HY-B0165A

Pravastatin sodium 5 Publications Verification CS-514 sodium	Cardiovascular Disease Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-B0165AR

Pravastatin sodium (Standard) 4 Publications Verification CS-514 sodium (Standard)	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Pravastatin (sodium) (Standard) is the analytical standard of Pravastatin (sodium). This product is intended for research and analytical applications. Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

HY-125400

Zaragozic acid C L-697350	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
Zaragozic acid C (L-697350) is a potent sterol synthase inhibitor with potential antitumor activity. Zaragozic acid C contains multiple hydroxyl and alkyl substituents in its chemical structure, demonstrating complex functionalization capabilities. The synthesis of zaragozic acid C involves a photochemical C(sp3)-H acylation reaction, which resolves the challenging carbon substitution problem in the synthesis .

Cat. No.	Product Name	Chemical Structure

HY-17396S

Butenafine-13C,d3 hydrochloride
Butenafine- ¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

HY-B0165CS

Pravastatin-d3 sodium salt
Pravastatin-d₃ (sodium) is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1][2].

HY-B0165AS

Pravastatin-13C,d3 sodium
Pravastatin- ¹³C,d₃ (sodium) is the ¹³C- and deuterium labeled Pravastatin (sodium). Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.

HY-B0165S

Pravastatin-d9 sodium
Pravastatin-d₉ sodium is deuterated labeled Pravastatin (HY-B0165). Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM .

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sterol synthesis

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
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