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Results for "

thiol-reactive

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

9

Fluorescent Dye

6

Biochemical Assay Reagents

1

Natural
Products

6

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0069
    CPM

    		Fluorescent Dye Others Cancer
    CPM is a maleimide derivative, acting as a blue fluorescent thiol-reactive dye. The excitation/emission maxima is 384/470 nm .
    CPM
  • HY-Y1147
    Diethyl maleate

    Maleic acid diethyl ester

    		 Biochemical Assay Reagents Others
    Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells .
    Diethyl maleate
  • HY-D1605
    BODIPY FL L-Cystine

    		Fluorescent Dye Others
    BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λex=504 nm, λem=511 nm) .
    BODIPY FL L-Cystine
  • HY-D1590
    BODIPY Green 8-P2M

    		Fluorescent Dye Others
    ODIPY Green 8-P2M is a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore, the fluorescence is strongly quenched by d-PeT and then can be restored after reaction with thiol, resulting in an extremely high signal-to-noise ratio. ODIPY Green 8-P2M can be useful for detecting extremely low concentrations of protein in the gel after SDS-PAGE .
    BODIPY Green 8-P2M
  • HY-149182
    Lucifer yellow iodoacetamide dipotassium

    		Fluorescent Dye Others
    Lucifer yellow iodoacetamide dipotassium is a thiol-reactive fluorescent tracer.
    Lucifer yellow iodoacetamide dipotassium
  • HY-D1754
    Lucifer yellow CH ammonium

    LYCH ammonium

    		 Fluorescent Dye Others
    Lucifer yellow CH (LYC) ammonium is a thiol-reactive fluorescent polar tracer.
    Lucifer yellow CH ammonium
  • HY-W800786
    16:0 PE MCC

    N-MCC-PE

    		 Liposome Cancer
    16:0 PE MCC is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a maleimide group.
    16:0 PE MCC
  • HY-W800787
    18:1 PE MCC

    		Liposome Cancer
    18:1 PE MCC is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a maleimide group.
    18:1 PE MCC
  • HY-W800788
    18:1 MPB PE

    		Liposome Cancer
    18:1 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a phenyl maleimide group.
    18:1 MPB PE
  • HY-W800789
    16:0 MPB PE

    		Liposome Cancer
    16:0 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a phenyl maleimide group.
    16:0 MPB PE
  • HY-114350
    BDP FL maleimide

    		Fluorescent Dye Others
    BDP FL maleimide is a thiol-reactive dye (Ex: 503 nm; Em: 509 nm). BDP FL maleimide can be used for protein labeling, peptide modification, and can replace fluorescein (FAM) for microscopy .
    BDP FL maleimide
  • HY-108534
    PMX464

    AW 464

    		 TrxR Inflammation/Immunology Cancer
    PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells .
    PMX464
  • HY-D2381
    AF 488 maleimide

    		Fluorescent Dye Others
    AF 488 maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach AF 488 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules. AF488 exhibits the λem and λex wavelength of 520 nm and 470 nm, respectively .
    AF 488 maleimide
  • HY-D2093
    PE-VF750 Maleimide

    		Fluorescent Dye Others
    PE-VF750 Maleimide is a thiol-reactive double-dye dye that contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/777 nm. PE-VF750 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 777 nm.
    PE-VF750 Maleimide
  • HY-W440955
    Stearic acid-PEG-CH2CO2H (MW 3400)

    		Biochemical Assay Reagents Others
    Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.
    Stearic acid-PEG-CH2CO2H (MW 3400)
  • HY-D1744
    ICG Maleimide

    		Fluorescent Dye Others
    ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging.
    ICG Maleimide
  • HY-148520
    QM295

    		Others Metabolic Disease
    QM295 is an endoplasmic reticulum oxidation 1 (ERO1) inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress .
    QM295
  • HY-W440727
    Cholesterol-PEG-Vinylsulfone (MW 2000)

    		Liposome Cancer
    Cholesterol-PEG-Vinylsulfone (MW 2000) is a thiol reactive polyPEG via thiol-ene reaction to form a thioether bond. It can self-assemble in water and is used to prepare liposome as drug vehicle for targeted delivery into tissues.
    Cholesterol-PEG-Vinylsulfone (MW 2000)
  • HY-W441007
    DSPE-Mal

    		Liposome Inflammation/Immunology Cancer
    DSPE-MAL is a thiol reactive a phospholipid compound. DSPE-MAL has two saturated fatty acids and can self-assemble in water to form lipid bilayer. DSPE-MAL can be used to prepare liposomes as agent nanocarrier .
    DSPE-Mal
  • HY-W440906
    DSPE-PEG-Vinylsulfone (MW 3400)

    		Biochemical Assay Reagents Others
    DSPE-PEG-Vinylsulfone, MW 3400 is a thiol reactive PEG lipid. The polymer can self-assemble spontaneously in aqueous solution to form lipid bilayer and be used to prepare nanoparticles/liposomes for drug delivery, for example mRNA vaccine or DNA vaccine. Reagent grade, for research use only.
    DSPE-PEG-Vinylsulfone (MW 3400)
  • HY-W440899
    DSPE-PEG-SPDP (MW 1000)

    		Liposome Others
    DSPE-PEG-SPDP, MW 1000 is a thiol reactive PEG lipid. The polymer is amphiphilic and spontaneously forms lipid bilayer in water. It can be used to encapsulate nutrients or therapeutics for targeted drug delivery, for example mRNA or DNA vaccine, liposomal doxorubicin for anti tumor. Reagent grade, for research use only.
    DSPE-PEG-SPDP (MW 1000)
  • HY-W441003
    DSPE-PEG-IA (MW 2000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-IA, MW 2000 is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine. Reagent grade, for research use only.
    DSPE-PEG-IA (MW 2000)
  • HY-D1363
    BDP R6G maleimide

    		Fluorescent Dye Others
    BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .
    BDP R6G maleimide
  • HY-136675
    ASMI

    		Others Others
    ASMI is a novel ratiometric two-photon fluorescent probe that can selectively detect and monitor mitochondrial Cys with rapid responsiveness and high contrast and brightness imaging of living cells and intact tissues at a depth of 150 μm. ASMI consists of highly two-photon active biocompatible merocyanine fluorescein and an acrylic acid group as a thiol reactive site. It has been extensively explored as a fluorescent sensing or imaging probe due to its easily tunable organelle targeting and large two-photon absorption properties. Some acrylic acid-functionalized probes tend to react more actively with Cys than with Hcy and GSH. The reaction mechanism involves the conjugate addition of Cys to acrylic acid to generate a thioether, followed by intramolecular cyclization to generate merocyanine fluorescein and a cyclic amide (Scheme 1). Importantly, the biocompatible and photostable ASMI and merocyanine show very large two-photon action cross sections (Φσmax) of 65.2 GM (λex = 740 nm) and 72.6 GM (λex = 760 nm), respectively, which make them have great potential in high-contrast and bright ratiometric two-photon excitation bioimaging applications. ASMI is a ratiometric fluorescent probe that exhibits a two-photon excitation mode for highly selective detection and imaging of mitochondrial Cys in living cells and deep tissue applications.
    ASMI

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