Search Result

Results for "

thiol-reactive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (8) Endoplasmic Reticulum Oxidoreductase 1 (ERO1) (1) Fluorescent Dye (11) Liposome (6) TrxR (1)
By Research Areas:	Cancer (7) Inflammation/Immunology (1) Metabolic Disease (1)
Oligonucleotides:	Pegylated Lipids (1) Phospholipids (4)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Oligonucleotides

Targets Recommended: Reactive Oxygen Species

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0069

CPM	Fluorescent Dye	Others Cancer
CPM is a maleimide derivative, acting as a blue fluorescent thiol-reactive dye (excitation/emission maxima of 387/463 nm) .

HY-D1605

BODIPY FL L-Cystine	Fluorescent Dye	Others
BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λ_ex=504 nm, λ_em=511 nm) .

HY-D1590

BODIPY Green 8-P2M	Fluorescent Dye	Others
ODIPY Green 8-P2M is a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore, the fluorescence is strongly quenched by d-PeT and then can be restored after reaction with thiol, resulting in an extremely high signal-to-noise ratio. ODIPY Green 8-P2M can be useful for detecting extremely low concentrations of protein in the gel after SDS-PAGE .

HY-149182

Lucifer yellow iodoacetamide dipotassium	Fluorescent Dye	Others
Lucifer yellow iodoacetamide dipotassium is a thiol-reactive fluorescent tracer.

HY-D1754

Lucifer yellow CH ammonium LYCH ammonium	Fluorescent Dye	Others
Lucifer yellow CH (LYC) ammonium is a thiol-reactive fluorescent polar tracer.

HY-W800787

18:1 PE MCC	Liposome	Cancer
18:1 PE MCC is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a maleimide group.

HY-W800786

16:0 PE MCC N-MCC-PE	Liposome	Cancer
16:0 PE MCC is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a maleimide group.

HY-W800789

16:0 MPB PE	Liposome	Cancer
16:0 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two palmitic acid tails and a phenyl maleimide group.

HY-W800788

18:1 MPB PE	Liposome	Cancer
18:1 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a phenyl maleimide group.

HY-114350

BDP FL maleimide	Fluorescent Dye	Others
BDP FL maleimide is a thiol-reactive dye (Ex: 503 nm; Em: 509 nm). BDP FL maleimide can be used for protein labeling, peptide modification, and can replace fluorescein (FAM) for microscopy .

HY-108534

PMX464 AW 464	TrxR	Inflammation/Immunology Cancer
PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells .

HY-D2381

AF 488 maleimide	Fluorescent Dye	Others
AF 488 maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach AF 488 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules. AF488 exhibits the λ_em and λ_ex wavelength of 520 nm and 470 nm, respectively .

HY-D2093

PE-VF750 Maleimide	Fluorescent Dye	Others
PE-VF750 Maleimide is a thiol-reactive double-dye dye that contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/777 nm. PE-VF750 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 777 nm.

HY-W800719

N-Boc-N'-(PEG1-t-butyl ester)-L-Lysine-amido-Mal	Biochemical Assay Reagents	Others
N-Boc-N'-(PEG1-t-butyl ester)-L-Lysine-amido-Mal is the amino acid, lysine, with a maleimide at its C-terminus, a Boc-protecting group on its α-amine, and an amido-PEG1-t-butyl ester on its ε-amine. Maleimide is a thiol-reactive covalent group used to conjugate cysteine residues, while the Boc and the t-butyl ester can be later deprotected to perform further reactions.

HY-W440955

Stearic acid-PEG-CH2CO2H (MW 3400)	Biochemical Assay Reagents	Others
Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.

HY-D1744

ICG Maleimide	Fluorescent Dye	Others
ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging.

HY-W800714

SPDP-Gly-Gly-methoxy	Biochemical Assay Reagents	Others
SPDP-Gly-Gly-methoxy is a linker with SPDP and methyl ester moiety. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions.

HY-148520

QM295	Endoplasmic Reticulum Oxidoreductase 1 (ERO1)	Metabolic Disease
QM295 is an endoplasmic reticulum oxidation 1 (ERO1) inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress .

HY-W440727

Cholesterol-PEG-Vinylsulfone (MW 2000)	Liposome	Cancer
Cholesterol-PEG-Vinylsulfone (MW 2000) is a thiol reactive polyPEG via thiol-ene reaction to form a thioether bond. It can self-assemble in water and is used to prepare liposome as drug vehicle for targeted delivery into tissues.

HY-W800711

SPDP-Gly-Pro-NHS ester	Biochemical Assay Reagents	Others
SPDP-Gly-Pro-NHS ester is a linker with SPDP and NHS ester moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The NHS ester is amine reactive and forms stable amide bonds.

HY-W440906

DSPE-PEG-Vinylsulfone (MW 3400)	Biochemical Assay Reagents	Others
DSPE-PEG-Vinylsulfone, MW 3400 is a thiol reactive PEG lipid. The polymer can self-assemble spontaneously in aqueous solution to form lipid bilayer and be used to prepare nanoparticles/liposomes for drug delivery, for example mRNA vaccine or DNA vaccine. Reagent grade, for research use only.

HY-W440899

DSPE-PEG-SPDP (MW 1000)	Liposome	Others
DSPE-PEG-SPDP, MW 1000 is a thiol reactive PEG lipid. The polymer is amphiphilic and spontaneously forms lipid bilayer in water. It can be used to encapsulate nutrients or therapeutics for targeted drug delivery, for example mRNA or DNA vaccine, liposomal doxorubicin for anti tumor. Reagent grade, for research use only.

HY-W800713

SPDP-Gly-Pro-acid	Biochemical Assay Reagents	Others
SPDP-Gly-Pro-acid is a linker with SPDP and carboxylic acid moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W441003

DSPE-PEG-IA (MW 2000)	Biochemical Assay Reagents	Others
DSPE-PEG-IA, MW 2000 is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine. Reagent grade, for research use only.

HY-D1363

BDP R6G maleimide	Fluorescent Dye	Others
BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .

HY-136675

ASMI	Fluorescent Dye	Others
ASMI is a ratiometric, two-photon excited fluorescent probe, composed of a highly two-photon active and biocompatible merocyanine fluorophore and an acrylate moiety as a thiol reactive site. ASMI is able to selectively detect and monitor mitochondrial Cys with rapid responsiveness, imaging living cells and intact tissues with high contrast and brightness at a depth of 150 μm. The two-photon action cross section (Φσmax) of ASMI is 65.2 GM, corresponding to an excitation wavelength (λex) of 740 nm.

HY-Y1147

Diethyl maleate 1 Publications Verification Maleic acid diethyl ester	Biochemical Assay Reagents	Others
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

Cat. No.	Product Name	Type

HY-D0069

CPM	Fluorescent Dyes/Probes
CPM is a maleimide derivative, acting as a blue fluorescent thiol-reactive dye (excitation/emission maxima of 387/463 nm) .

HY-D1605

BODIPY FL L-Cystine	Fluorescent Dyes/Probes
BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λ_ex=504 nm, λ_em=511 nm) .

HY-D2381

AF 488 maleimide	Fluorescent Dyes/Probes
AF 488 maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach AF 488 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules. AF488 exhibits the λ_em and λ_ex wavelength of 520 nm and 470 nm, respectively .

HY-D1744

ICG Maleimide	Fluorescent Dyes/Probes
ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging.

HY-149182

Lucifer yellow iodoacetamide dipotassium	Fluorescent Dyes/Probes
Lucifer yellow iodoacetamide dipotassium is a thiol-reactive fluorescent tracer.

HY-D1754

Lucifer yellow CH ammonium LYCH ammonium	Fluorescent Dyes/Probes
Lucifer yellow CH (LYC) ammonium is a thiol-reactive fluorescent polar tracer.

HY-114350

BDP FL maleimide	Fluorescent Dyes/Probes
BDP FL maleimide is a thiol-reactive dye (Ex: 503 nm; Em: 509 nm). BDP FL maleimide can be used for protein labeling, peptide modification, and can replace fluorescein (FAM) for microscopy .

HY-D2093

PE-VF750 Maleimide	Protein Labeling
PE-VF750 Maleimide is a thiol-reactive double-dye dye that contains maleimide groups that can react with thiol groups to form covalent bonds. Ex/Em=495-566/777 nm. PE-VF750 Maleimide contains two dyes, PE and VF, with excitation wavelengths (Ex) of 495 nm and 566 nm, respectively. PE-VF594 Maleimide has an emission wavelength (Em) of 777 nm.

HY-D1363

BDP R6G maleimide	Fluorescent Dyes/Probes
BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .

BDP R6G maleimide

Fluorescent Dyes/Probes

BDP R6G maleimide is a borodipyrromethane fluorophore with absorption and emission wavelengths similar to those of R6G rhodamine. Sulfhydryl labelling is a common protein modification where the cysteine residues in the protein allow more site-specific labelling than the NHS ester of the amine group. BDP R6G maleimide is a thiol reactive dye that reacts with thiol groups to form thioester bonds .

Cat. No.	Product Name	Type

HY-Y1147

Diethyl maleate 1 Publications Verification Maleic acid diethyl ester	Biochemical Assay Reagents
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

Diethyl maleate

1 Publications Verification

Maleic acid diethyl ester

Biochemical Assay Reagents

Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

HY-W440955

Stearic acid-PEG-CH2CO2H (MW 3400)	Drug Delivery
Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.

Stearic acid-PEG-CH2CO2H (MW 3400)

Drug Delivery

Stearic acid-PEG-CH2CO2H, MW 3400 is a lipophilic thiol-reactive PEG polymer. The stearic acid can be used to encapsulate hydrophobic therapeutic agents while the PEG chain increases overall water solubility and biocompatibilty. Reaction between carboxylic acid (-COOH) and amine (-NH2) vai condensation in the presence of activator, such as HATU or EDC, generates a stable amide linkage. Reagent grade, for research use only.