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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

tyrosine hydroxylase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Calcium Channel (3) COX (3) Cyclic GMP-AMP Synthase (3) Endogenous Metabolite (2) ERK (3) GABA Receptor (1) Imidazoline Receptor (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (1) nAChR (1) NF-κB (1) Opioid Receptor (1) PKA (3) Thyroid Hormone Receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (6) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (3)

12

Inhibitors & Agonists

1

Peptides

3

Natural
Products

2

Isotope-Labeled Compounds

Targets Recommended: Tryptophan Hydroxylase Dopamine β-hydroxylase HIF/HIF Prolyl-Hydroxylase Btk Syk DYRK Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

α-Methyltyrosine methyl ester hydrochloride	Thyroid Hormone Receptor Others	Neurological Disease
α-Methyltyrosine methyl ester hydrochloride is a competitive **tyrosine hydroxylase** inhibitor that inhibits the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .

α-Methyl-p-tyrosine	Others	Neurological Disease Cancer
α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases .

Metyrosine	COX	Cardiovascular Disease
Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

H-Tyr(3-I)-OH	Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH is a potent and effective **tyrosine hydroxylase** inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HA-1004	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-W015007R

Metyrosine (Standard)	COX	Cardiovascular Disease
Metyrosine (Standard) is the analytical standard of Metyrosine. This product is intended for research and analytical applications. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .

Catalpalactone	NF-κB	Inflammation/Immunology
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

HY-W015007S

Metyrosine-13C9,15N,d7	COX	Cardiovascular Disease
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

HY-W008452S

H-Tyr(3-I)-OH-13C6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

HA-1004 di(hydrochloride)	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HA-1004 hydrochloride	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

Harmane 1 Publications Verification	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor	Neurological Disease Inflammation/Immunology
Harmane is an inhibitor that binds to benzodiazepine receptors (with an IC₅₀ value of 7 μM), has an IC₅₀ of 24 μM for muscarinic acetylcholine receptors (QNB), an IC₅₀ of 2.8 μM for opioid receptors, and IC₅₀ values of 163 and 101 μM for spironolactone and serotonin, respectively. Harmane is a selective monoamine oxidase inhibitor (with IC₅₀ values of 0.5 μM for MAO A and 5 μM for MAO B). Harman inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing levodopa (L-DOPA)-induced toxicity in PC12 cells. Harmane lowers blood pressure in rats through the I1 imidazoline receptor (I1 receptor) and has antidepressant, anxiolytic, anticonvulsant, and analgesic effects. Harmane enhances the mutagenicity induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name	Category	Target	Chemical Structure

H-Tyr(3-I)-OH	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-Tyr(3-I)-OH is a potent and effective **tyrosine hydroxylase** inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is an inhibitor that binds to benzodiazepine receptors (with an IC₅₀ value of 7 μM), has an IC₅₀ of 24 μM for muscarinic acetylcholine receptors (QNB), an IC₅₀ of 2.8 μM for opioid receptors, and IC₅₀ values of 163 and 101 μM for spironolactone and serotonin, respectively. Harmane is a selective monoamine oxidase inhibitor (with IC₅₀ values of 0.5 μM for MAO A and 5 μM for MAO B). Harman inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing levodopa (L-DOPA)-induced toxicity in PC12 cells. Harmane lowers blood pressure in rats through the I1 imidazoline receptor (I1 receptor) and has antidepressant, anxiolytic, anticonvulsant, and analgesic effects. Harmane enhances the mutagenicity induced by 2-acetylaminofluorene (AAF) .

Catalpalactone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .

Cat. No.	Product Name	Chemical Structure

HY-W015007S

Metyrosine-13C9,15N,d7
Metyrosine- ¹³C₉, ¹⁵N,d₇ is the deuterium, ¹³C-, and 15-labeled Metyrosine. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

HY-W008452S

H-Tyr(3-I)-OH-13C6
H-Tyr(3-I)-OH- ¹³C₆ is the ¹³C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

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