2. PROTAC GPCR/G Protein MAPK/ERK Pathway
  3. PROTACs Ras
  4. Setidegrasib

Setidegrasib  (Synonyms: KRAS G12D inhibitor 17)

Cat. No.: HY-148273 Purity: 99.42%
SDS COA Handling Instructions

Molarity Calculator

Setidegrasib (Example 8) is a PROTAC KRAS degrader. Setidegrasib is a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, inducing the degradation of G12D-mutation KRAS protein. Setidegrasib is expected to be used in cancer research. (Blue: HY-168699; Black: linker (HY-168698); Pink: HY-168700).

For research use only. We do not sell to patients.

Setidegrasib Chemical Structure

Setidegrasib Chemical Structure

CAS No. : 2821793-99-9

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1 mg USD 1250 In-stock
5 mg USD 2503 In-stock
10 mg USD 3700 In-stock
25 mg USD 6300 In-stock
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Based on 1 publication(s) in Google Scholar

Setidegrasib Related Antibodies

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K-Ras H-Ras N-Ras Ras

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Setidegrasib (Example 8) is a PROTAC KRAS degrader. Setidegrasib is a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, inducing the degradation of G12D-mutation KRAS protein. Setidegrasib is expected to be used in cancer research. (Blue: HY-168699; Black: linker (HY-168698); Pink: HY-168700)[1].

IC50 & Target

KRAS(G12D)

 

Molecular Weight

1117.30

Formula

C60H65FN12O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C(C(C(C1CC1)=CC(C(N2[C@@](CN3)([H])C[C@@]3([H])C2)=N4)=C5N=C4OC6CCOCC6)=C5OCC7=CC=C(C(N=N8)=CN8[C@@H](C(C)C)C(N(C[C@@H]9O)[C@@H](C9)C(N[C@H](C%10=CC=C(C(SC=N%11)=C%11C)C=C%10)CO)=O)=O)C=C7)=C(C=NN%12)C%12=C%13)=C%13F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (89.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8950 mL 4.4751 mL 8.9501 mL
5 mM 0.1790 mL 0.8950 mL 1.7900 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.65%

SDS (252 KB)

COA (252 KB) HNMR (228 KB) RP-HPLC (118 KB) LCMS (145 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8950 mL 4.4751 mL 8.9501 mL 22.3754 mL
5 mM 0.1790 mL 0.8950 mL 1.7900 mL 4.4751 mL
10 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2375 mL
15 mM 0.0597 mL 0.2983 mL 0.5967 mL 1.4917 mL
20 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
25 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8950 mL
30 mM 0.0298 mL 0.1492 mL 0.2983 mL 0.7458 mL
40 mM 0.0224 mL 0.1119 mL 0.2238 mL 0.5594 mL
50 mM 0.0179 mL 0.0895 mL 0.1790 mL 0.4475 mL
60 mM 0.0149 mL 0.0746 mL 0.1492 mL 0.3729 mL
80 mM 0.0112 mL 0.0559 mL 0.1119 mL 0.2797 mL
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Setidegrasib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setidegrasib2821793-99-9KRAS G12D inhibitor 17PROTACsRasquinazoline-linked (4R)-4-hydroxy-L-prolinamide compoundprotein degradationG12D-mutationInhibitorinhibitorinhibit

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