2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase
  4. SGP8

SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the JNK-c-Jun signaling pathway, and has the ability to inhibit non-alcoholic steatohepatitis (NASH).

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SGP8 Chemical Structure

SGP8 Chemical Structure

CAS No. : 855790-98-6

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SGP8 Related Antibodies

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Description

SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the JNK-c-Jun signaling pathway, and has the ability to inhibit non-alcoholic steatohepatitis (NASH)[1].

IC50 & Target[1]

DPP-4

 

In Vitro

SGP8 (0,100 and 500 µM; 24 h) has regulatory effects on lipid metabolism, inflammation, and fibrosis [1].
SGP8 (0,100 and 500 µM; 24 h) increases significantly the serum GLP-1 content and targets DPP4 with an inhibitory activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGP8 Related Antibodies

Real Time qPCR[1]

Cell Line: L02 cells
Concentration: 0,100 and 500 µM
Incubation Time: 24h
Result: Improved the mRNA expression of lipid metabolism genes related to Cd36, Scd1, Cpt1 and Pparα and significantly reduced the mRNA expression of inflammatory genes Tnfα, Il-1β, and Ccl5.

Western Blot Analysis[1]

Cell Line: L02 cells
Concentration: 0,100 and 500 µM
Incubation Time: 24h
Result: Reduced the expression of lipid metabolism genes related to CD36, FAS, and SREBP-1 compared to the 1 mM PO model group.

Immunofluorescence[1]

Cell Line: LX2 cells
Concentration: 0 and 500 µM
Incubation Time: 24h
Result: Reduced effectively TGFβ1-induced expression of α-SMA and Collagen I protein expression.
In Vivo

SGP8 (15 mg/kg, ip; everyday for four weeks) can alleviate MCD diet-induced steatohepatitis in mice[1].
SGP8 (15 mg/kg, ip; everyday for eight weeks) mitigates HFD-induced hepatic injury and metabolic disorders in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy 7-week-old male C57BL/6J mice (22 and 27 g)[1]
Dosage: 15 mg/kg; everydays for four weeks
Administration: i.g.
Result: Did not reverse the weight loss of mice caused by the MCD diet. Reduces the ratio of liver weight to body weight, as well as liver TG and TC content. Reduces the activities of ALT and AST in the serum of MCD dietinduced NASH mice. Improved liver fibrosis in MCD diet-induced NASH mice.
Molecular Weight

754.87

Formula

C34H58N8O11
CAS No.
Sequence

Ile-Ala-Val-Pro-Gly-Glu-Val-Ala
Sequence Shortening

IAVPGEVA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SGP8 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGP8855790-98-6SGP 8SGP-8Dipeptidyl PeptidaseDPPNonalcoholic steatohepatitis (NASH)JNK-c-Jun pathwayDPP4L02 and LX2 cellsInhibitorinhibitorinhibit

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