2. Immunology/Inflammation TGF-beta/Smad
  3. PD-1/PD-L1 TGF-β Receptor
  4. SHR-1701

SHR-1701  (Synonyms: Retlirafusp alfa)

Cat. No.: HY-P99944 Purity: 99.77%
COA

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SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research.

For research use only. We do not sell to patients.

CAS No. : 2891860-17-4

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1 mg USD 360 In-stock
5 mg USD 940 In-stock
10 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

SHR-1701 Related Antibodies

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Description

SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1].

In Vitro

SHR-1701 (10 μg/mL) can inhibit TGF-β signaling pathway, activate PI3K/Akt/Erk signaling pathway, rescue lymphocytes and restore the anti-tumor function of peripheral blood CD8+ T cells in patients with lung cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SHR-1701 Related Antibodies
Molecular Weight

33.07

Formula

HS
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

S[R1701]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human PD-L1/B7-H1 Protein (ECD, His Tag) can bind SHR-1701. The EC50 for this effect is 0.42 ng/mL.
Purity & Documentation
References
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SHR-1701 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHR-17012891860-17-4Retlirafusp alfaSHR1701SHR 1701PD-1/PD-L1TGF-β ReceptorPD-1/Programmed death-ligand 1Transforming growth factor beta receptorsPD-L1TGF-βcancerInhibitorinhibitorinhibit

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