Siphonaxanthin 

Siphonaxanthin is a keto-carotenoid found in green algae. Siphonaxanthin targets death receptor 5 (DR5) and induces apoptosis in cancer cells. Siphonaxanthin upregulates the expression of DR5, decreases the expression of Bcl-2, and activates caspase-3 in human leukemia HL-60 cells. Siphonaxanthin is an inhibitor of fibroblast growth factor receptor-1 (FGFR-1) signaling transduction in vascular endothelial cells. Siphonaxanthin inhibits the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs), as well as the outgrowth of microvessels in the rat aortic ring. Siphonaxanthin can also inhibit the translocation of the high-affinity IgE receptor (FcεRI) to lipid rafts in mast cells, acting as an anti-inflammatory agent. Siphonaxanthin is promising for research of diseases such as cancer, diabetic retinopathy, and rheumatoid arthritis^[1].

600.87

C₄₀H₅₆O₄

28526-44-5

CC(C)(C[C@H](C=C1C)O)[C@H]1/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(CO)/C(CC2=C(C)C[C@@H](O)CC2(C)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sugawara T, et al. Siphonaxanthin, a green algal carotenoid, as a novel functional compound. Mar Drugs. 2014 Jun 19;12(6):3660-8.  [Content Brief]