2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. JAK PROTACs
  4. SJ1008030 TFA

SJ1008030 (compound 8) TFA is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia.

For research use only. We do not sell to patients.

SJ1008030 TFA Chemical Structure

SJ1008030 TFA Chemical Structure

CAS No. : 2863634-97-1

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Based on 1 publication(s) in Google Scholar

Other Forms of SJ1008030 TFA:

SJ1008030 TFA Related Antibodies

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Description

SJ1008030 (compound 8) TFA is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia[1].

IC50 & Target[1]

JAK2

 

In Vitro

SJ1008030 (compound 8) (72 h) TFA shows activity in CRLF2r cell lines (MHH-CALL-4), with an IC50 of 5.4 nM[1].
SJ1008030 (0-4.3 μM; 72 h) TFA degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH–CALL-4 cells[1].
SJ1008030 (0-10 μM; 24h) TFA dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of JAK-STAT signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SJ1008030 TFA Related Antibodies
Molecular Weight

987.96

Formula

C44H44F3N13O9S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(CC)(N1CC(N2C=C(C=N2)C3=C4C=CNC4=NC(NC5=CC=C(C=C5)C(NCCN6CCN(CC6)C7=CC=C8C(N(C9CCC(NC9=O)=O)C(C8=C7)=O)=O)=O)=N3)(CC#N)C1)=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (126.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0122 mL 5.0609 mL 10.1219 mL
5 mM 0.2024 mL 1.0122 mL 2.0244 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

COA (252 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0122 mL 5.0609 mL 10.1219 mL 25.3047 mL
5 mM 0.2024 mL 1.0122 mL 2.0244 mL 5.0609 mL
10 mM 0.1012 mL 0.5061 mL 1.0122 mL 2.5305 mL
15 mM 0.0675 mL 0.3374 mL 0.6748 mL 1.6870 mL
20 mM 0.0506 mL 0.2530 mL 0.5061 mL 1.2652 mL
25 mM 0.0405 mL 0.2024 mL 0.4049 mL 1.0122 mL
30 mM 0.0337 mL 0.1687 mL 0.3374 mL 0.8435 mL
40 mM 0.0253 mL 0.1265 mL 0.2530 mL 0.6326 mL
50 mM 0.0202 mL 0.1012 mL 0.2024 mL 0.5061 mL
60 mM 0.0169 mL 0.0843 mL 0.1687 mL 0.4217 mL
80 mM 0.0127 mL 0.0633 mL 0.1265 mL 0.3163 mL
100 mM 0.0101 mL 0.0506 mL 0.1012 mL 0.2530 mL
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SJ1008030 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ10080302863634-97-1SJ 1008030SJ-1008030JAKPROTACsJanus kinaseantileukemiCRLF2r ALLMHH–CALL-4JAK-STAT signaling pathwaydegraderInhibitorinhibitorinhibit

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