2. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. PROTACs EGFR
  4. SJF-1528 hemihydrate

SJF-1528 hemihydrate is the hemihydrate form of SJF-1528 (HY-131864). SJF-1528 hemihydrate is a EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutated EGFR in HeLa cells. SJF-1528 hemihydrate also degrades HER2. (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

For research use only. We do not sell to patients.

SJF-1528 hemihydrate Chemical Structure

SJF-1528 hemihydrate Chemical Structure

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1 mg USD 340 In-stock
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Other Forms of SJF-1528 hemihydrate:

SJF-1528 hemihydrate Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SJF-1528 hemihydrate is the hemihydrate form of SJF-1528 (HY-131864). SJF-1528 hemihydrate is a EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutated EGFR in HeLa cells. SJF-1528 hemihydrate also degrades HER2. (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845))[1]

Molecular Weight

1039.62

Formula

C55H57ClFN7O8S.1/2H2O
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@H]1N(C([C@@H](NC(COCCOCCOC2=CC=C(C3=CC4=C(NC5=CC=C(OCC6=CC=CC(F)=C6)C(Cl)=C5)N=CN=C4C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7.[1/2].O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 104 mg/mL (100.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9619 mL 4.8094 mL 9.6189 mL
5 mM 0.1924 mL 0.9619 mL 1.9238 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.90%

SDS (252 KB)

COA (252 KB) Elemental Analysis Report (110 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9619 mL 4.8094 mL 9.6189 mL 24.0472 mL
5 mM 0.1924 mL 0.9619 mL 1.9238 mL 4.8094 mL
10 mM 0.0962 mL 0.4809 mL 0.9619 mL 2.4047 mL
15 mM 0.0641 mL 0.3206 mL 0.6413 mL 1.6031 mL
20 mM 0.0481 mL 0.2405 mL 0.4809 mL 1.2024 mL
25 mM 0.0385 mL 0.1924 mL 0.3848 mL 0.9619 mL
30 mM 0.0321 mL 0.1603 mL 0.3206 mL 0.8016 mL
40 mM 0.0240 mL 0.1202 mL 0.2405 mL 0.6012 mL
50 mM 0.0192 mL 0.0962 mL 0.1924 mL 0.4809 mL
60 mM 0.0160 mL 0.0802 mL 0.1603 mL 0.4008 mL
80 mM 0.0120 mL 0.0601 mL 0.1202 mL 0.3006 mL
100 mM 0.0096 mL 0.0481 mL 0.0962 mL 0.2405 mL
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SJF-1528 hemihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJF-1528 hemihydratePROTACsEGFREpidermal growth factor receptorErbB-1HER1OVCAR8HeLaInhibitorinhibitorinhibit

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