2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PROTAC
  3. EGFR PROTACs
  4. SJF-1528

SJF-1528 is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutated EGFR in HeLa cells. SJF-1528 also degrades HER2 (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)).

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SJF-1528 Chemical Structure

SJF-1528 Chemical Structure

CAS No. : 2230821-38-0

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Based on 1 publication(s) in Google Scholar

Other Forms of SJF-1528:

SJF-1528 Related Antibodies

Top Publications Citing Use of Products

View All EGFR Isoform Specific Products:

View All Isoforms
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • Purity & Documentation

  • References

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Description

SJF-1528 is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutated EGFR in HeLa cells. SJF-1528 also degrades HER2 (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845))[1].

Molecular Weight

1030.60

Formula

C55H57ClFN7O8S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C([C@@H](NC(COCCOCCOC2=CC=C(C3=CC4=C(NC5=CC=C(OCC6=CC=CC(F)=C6)C(Cl)=C5)N=CN=C4C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 103.06 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9703 mL 4.8515 mL 9.7031 mL
5 mM 0.1941 mL 0.9703 mL 1.9406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9703 mL 4.8515 mL 9.7031 mL 24.2577 mL
5 mM 0.1941 mL 0.9703 mL 1.9406 mL 4.8515 mL
10 mM 0.0970 mL 0.4852 mL 0.9703 mL 2.4258 mL
15 mM 0.0647 mL 0.3234 mL 0.6469 mL 1.6172 mL
20 mM 0.0485 mL 0.2426 mL 0.4852 mL 1.2129 mL
25 mM 0.0388 mL 0.1941 mL 0.3881 mL 0.9703 mL
30 mM 0.0323 mL 0.1617 mL 0.3234 mL 0.8086 mL
40 mM 0.0243 mL 0.1213 mL 0.2426 mL 0.6064 mL
50 mM 0.0194 mL 0.0970 mL 0.1941 mL 0.4852 mL
60 mM 0.0162 mL 0.0809 mL 0.1617 mL 0.4043 mL
80 mM 0.0121 mL 0.0606 mL 0.1213 mL 0.3032 mL
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SJF-1528 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJF-15282230821-38-0SJF1528SJF 1528EGFRPROTACsEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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