2. Metabolic Enzyme/Protease
  3. PAI-1
  4. SK-216

SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma.

For research use only. We do not sell to patients.

SK-216 Chemical Structure

SK-216 Chemical Structure

CAS No. : 654080-03-2

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Based on 1 publication(s) in Google Scholar

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Description

SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma[1].

In Vitro

SK-216 (0-50 μM, 48 h) can inhibit the invasion of 143B cells in a dose-dependent manner, but does not affect cell proliferation and migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SK-216 Related Antibodies

Western Blot Analysis [1]

Cell Line: human osteosarcoma cell line 143B
Concentration: 0, 25, 50 μM
Incubation Time: 48 h
Result: Inhibited PAI-1 expression by 40% at concentrations of 25 and 50 μM，and lead to a significantly lower ratio of cell-invaded wells/total wells.
Inhibited MMP-13 secretion in 143B cells.
In Vivo

SK-216 (i.p., 6.6 μg/200 μL in PBS, once every 3 days) inhibits lung metastasis of human osteosarcoma cells, but not tumor growth in primary tumors in male athymic nude mice with 143B-Luc cell model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-6-week-old male athymic nude mice with 143B-Luc cell[1]
Dosage: 6.6 μg/200 μL in PBS
Administration: i.p., once every 3 days
Result: Resulted in a significant reduction in PAI-1 expression levels in primary lesions in mice.
Molecular Weight

533.52

Formula

C29H29NNa2O6
CAS No.
SMILES

O=C(O[Na])C(CCCCCOC1=CC=C2C=C(C3=NC4=CC(C(C)(C)C)=CC=C4O3)C=CC2=C1)C(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SK-216 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK-216654080-03-2SK216SK 216PAI-1Plasminogen activator inhibitor-1plasminogenosteosarcomametastasisInhibitorinhibitorinhibit

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