2. Metabolic Enzyme/Protease
  3. PAI-1
  4. SK-216

SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma.

For research use only. We do not sell to patients.

SK-216 Chemical Structure

SK-216 Chemical Structure

CAS No. : 654080-03-2

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Based on 1 publication(s) in Google Scholar

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Description

SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma[1].

In Vitro

SK-216 (0-50 μM, 48 h) can inhibit the invasion of 143B cells in a dose-dependent manner, but does not affect cell proliferation and migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SK-216 Related Antibodies

Western Blot Analysis [1]

Cell Line: human osteosarcoma cell line 143B
Concentration: 0, 25, 50 μM
Incubation Time: 48 h
Result: Inhibited PAI-1 expression by 40% at concentrations of 25 and 50 μM，and lead to a significantly lower ratio of cell-invaded wells/total wells.
Inhibited MMP-13 secretion in 143B cells.
In Vivo

SK-216 (i.p., 6.6 μg/200 μL in PBS, once every 3 days) inhibits lung metastasis of human osteosarcoma cells, but not tumor growth in primary tumors in male athymic nude mice with 143B-Luc cell model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-6-week-old male athymic nude mice with 143B-Luc cell[1]
Dosage: 6.6 μg/200 μL in PBS
Administration: i.p., once every 3 days
Result: Resulted in a significant reduction in PAI-1 expression levels in primary lesions in mice.
Molecular Weight

533.52

Formula

C29H29NNa2O6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O[Na])C(CCCCCOC1=CC=C2C=C(C3=NC4=CC(C(C)(C)C)=CC=C4O3)C=CC2=C1)C(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 6.67 mg/mL (12.50 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8743 mL 9.3717 mL 18.7434 mL
5 mM 0.3749 mL 1.8743 mL 3.7487 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8743 mL 9.3717 mL 18.7434 mL 46.8586 mL
5 mM 0.3749 mL 1.8743 mL 3.7487 mL 9.3717 mL
10 mM 0.1874 mL 0.9372 mL 1.8743 mL 4.6859 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SK-216 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK-216654080-03-2SK216SK 216PAI-1Plasminogen activator inhibitor-1plasminogenosteosarcomametastasisInhibitorinhibitorinhibit

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