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SLC6A8 corrector 1 is an orally active and brain-penetrant mutant SLC6A8 variant corrector. SLC6A8 corrector 1 can be used for the study of creatine transporter deficiency (CTD).

For research use only. We do not sell to patients.

SLC6A8 corrector 1 Chemical Structure

SLC6A8 corrector 1 Chemical Structure

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SLC6A8 corrector 1 Related Antibodies

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Description

SLC6A8 corrector 1 is an orally active and brain-penetrant mutant SLC6A8 variant corrector. SLC6A8 corrector 1 can be used for the study of creatine transporter deficiency (CTD)[1].

In Vivo

SLC6A8 corrector 1 (compound 6; 30 mg/kg; oral gavage) increases brain creatine levels in heterozygous female mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female wildtype and P549L heterozygous C57/6J mice[1]
Dosage: 30 mg/kg (10% DMSO in 20% (w/v) HP-β-CD in water)
Administration: Oral gavage; once-daily (QD) for 4 days and twice-daily (BID) for 1 day
Result: Significantly increased brain creatine levels in the P549L heterozygous females toward wildtype levels.
Molecular Weight

351.44

Formula

C21H25N3O2
SMILES

C[C@@H]1CN(CC[C@@H]1O)C2=CC=NC(C(N[C@H]3C[C@@H]3C4=CC=CC=C4)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SLC6A8 corrector 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLC6A8 corrector 1OthersCorrector for Variant of SLC6A8brain-penetrantorally activecreatine transporter deficiencyInhibitorinhibitorinhibit

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