1. Immunology/Inflammation
  2. CD3
  3. Solitomab

Solitomab  (Synonyms: AMG 110; MT110)

Cat. No.: HY-P99592 Purity: 98.15%
COA

Solitomab (AMG 110) is a bispecific anti-CD3 and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer.

For research use only. We do not sell to patients.

CAS No. : 1005198-65-1

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5 mg USD 1680 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Solitomab (AMG 110) is a bispecific anti-CD3 and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer[1][2].

Isotype

(scFv-kappa-heavy)-(scFv-heavy-kappa)

Species

Mouse

In Vitro

Solitomab (1 μg/mL; 4 hours) shows cytotoxicity to EpCAM-positive cell lines and increases the sensibility of EpCAM positive carcinosarcomas (CS) cells to T-cell-cytotoxicity[1].
Solitomab (7 days) increases the expression level of CD25 and HLA-DR protein (T-cell activation markers) on CD8+ and CD4+ T cells[1].
Solitomab (0-2.5 μg/mL; 4 hours) is cytotoxic to ovarian carcinoma cells and the 1 μg/mL dose shows the best tumor killing effects[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Solitomab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • (scFv-kappa-heavy)-(scFv-heavy-kappa)
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Solitomab
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