2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Somatostatin-28 (sheep, human rat mouse)

Somatostatin-28 (sheep, human rat mouse) 

Cat. No.: HY-P3954 Purity: 99.40%
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Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion.

For research use only. We do not sell to patients.

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Somatostatin-28 (sheep, human rat mouse) Chemical Structure

Somatostatin-28 (sheep, human rat mouse) Chemical Structure

CAS No. : 73032-94-7

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5 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

Somatostatin-28 (sheep, human rat mouse) Related Antibodies

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

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Description

Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion[1][2].

IC50 & Target[2]

SSTR5

 

In Vitro

Somatostatin-28 dose-dependently inhibits GLP-1 secretion stimulated by gastrin-releasing peptide with an EC50 value of 0.01 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Somatostatin-28 (sheep, human rat mouse) Related Antibodies
In Vivo

Somatostatin-28 (sheep) (1.1 pmol/kg/min; i.v. via a jugular catheter; 15 min) inhibits insulin secretion induced by 25 μg/kg/min glucose in sheep[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)[2]
Dosage: 1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose;
Administration: Intravenous injection via a jugular catheter;
Result: Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L.
Molecular Weight

3148.56

Formula

C137H207N41O39S3
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge:Cys17-Cys28)
Sequence Shortening

SANSNPAMAPRERKAGCKNFFWKTFTSC (Disulfide bridge: Cys17-Cys28)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (31.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3176 mL 1.5880 mL 3.1761 mL
5 mM 0.0635 mL 0.3176 mL 0.6352 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3176 mL 1.5880 mL 3.1761 mL 7.9401 mL
5 mM 0.0635 mL 0.3176 mL 0.6352 mL 1.5880 mL
10 mM 0.0318 mL 0.1588 mL 0.3176 mL 0.7940 mL
15 mM 0.0212 mL 0.1059 mL 0.2117 mL 0.5293 mL
20 mM 0.0159 mL 0.0794 mL 0.1588 mL 0.3970 mL
25 mM 0.0127 mL 0.0635 mL 0.1270 mL 0.3176 mL
30 mM 0.0106 mL 0.0529 mL 0.1059 mL 0.2647 mL
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Somatostatin-28 (sheep, human rat mouse) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Somatostatin-28 (sheep, human rat mouse)73032-94-7Somatostatin ReceptorSSTRsSSTRInhibitorinhibitorinhibit

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