2. Inhibitory Antibodies
  3. Sontuzumab

Sontuzumab  (Synonyms: AS1402; huHMFG-1)

Cat. No.: HY-P99591 Purity: 99.66%
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Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer.

For research use only. We do not sell to patients.

CAS No. : 372075-37-1

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Sontuzumab Related Antibodies

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Description

Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer[1].

Isotype

Human IgG1
Recommend Isotype Controls
Species

Humanized
IC50 & Target

Kd: ~1 nM (MUC1)[1]
In Vitro

Sontuzumab (huHMFG-1; 0-25 μg/mL) induces antibody-dependent cellular cytotoxicity (ADCC) in the breast tumor cell line ZR-75-1, in three bone marrow-derived tumor cell lines from breast cancer patients (KM22, 1590, HG15), and in Chinese hamster ovary (CHO) cells transfected with the human MUC1 gene, by using peripheral blood mononuclear cells (PBMCs) from healthy donors. Cell lines that do not express human MUC1 are not susceptible to ADCC in the presence of Sontuzumab[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sontuzumab Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Sontuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 nd
Biological Activity
  • Immobilized Human MUC-1 Protein (His Tag) can bind Sontuzumab. The EC50 for this effect is 17.17 ng/mL.
Purity & Documentation
References
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Sontuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sontuzumab372075-37-1AS1402 huHMFG-1AS 1402AS-1402huHMFG1huHMFG 1huHMFG-1Othersbreast cancerADCCantibody-dependent cellular cytotoxicityZR-75-1Inhibitorinhibitorinhibit

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