1. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK Autophagy Apoptosis
  2. Raf VEGFR FLT3 Autophagy Apoptosis Ferroptosis
  3. Sorafenib-13C,d3

Sorafenib-13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

For research use only. We do not sell to patients.

Sorafenib-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Sorafenib-13C,d3 Chemical Structure

CAS No. : 1210608-86-8

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Based on 2 publication(s) in Google Scholar

Other Forms of Sorafenib-13C,d3:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sorafenib-13C,d3

Proliferation Assay

    Sorafenib-13C,d3 purchased from MedChemExpress. Usage Cited in: BMC Cancer. 2023 Jan 25;23(1):87.  [Abstract]

    Sorafenib-13C,d3 (SFB; 4 µM) shows inhibition on the clone formation efficiency of HCC cells.

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    Description

    Sorafenib-13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

    In Vitro

    Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    468.84

    Formula

    C2013CH13D3ClF3N4O3

    CAS No.
    Unlabeled CAS

    284461-73-0

    Appearance

    Solid

    Color

    Off-white to gray

    SMILES

    O=C(NC(C=C1)=CC=C1OC2=CC(C(N[13C]([2H])([2H])[2H])=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3

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    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 16.67 mg/mL (35.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1329 mL 10.6646 mL 21.3292 mL
    5 mM 0.4266 mL 2.1329 mL 4.2658 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1329 mL 10.6646 mL 21.3292 mL 53.3231 mL
    5 mM 0.4266 mL 2.1329 mL 4.2658 mL 10.6646 mL
    10 mM 0.2133 mL 1.0665 mL 2.1329 mL 5.3323 mL
    15 mM 0.1422 mL 0.7110 mL 1.4219 mL 3.5549 mL
    20 mM 0.1066 mL 0.5332 mL 1.0665 mL 2.6662 mL
    25 mM 0.0853 mL 0.4266 mL 0.8532 mL 2.1329 mL
    30 mM 0.0711 mL 0.3555 mL 0.7110 mL 1.7774 mL
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Sorafenib-13C,d3
    Cat. No.:
    HY-10201S2
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