2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Autophagy
  3. Mineralocorticoid Receptor Androgen Receptor Autophagy
  4. Spironolactone-d3

Spironolactone-d3  (Synonyms: SC9420-d3)

Cat. No.: HY-B0561S1 Purity: 99.82%
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Spironolactone-d3 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

For research use only. We do not sell to patients.

Spironolactone-d<sub>3</sub> Chemical Structure

Spironolactone-d3 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Spironolactone-d3:

Spironolactone-d3 Related Antibodies

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Description

Spironolactone-d3 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Spironolactone-d3 Related Antibodies
Molecular Weight

419.59

Formula

C24H29D3O4S
Unlabeled CAS

52-01-7
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@]3(OC(CC3)=O)CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H]4SC(C([2H])([2H])[2H])=O)=CC(CC5)=O)C)([H])CC2
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (119.16 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3833 mL 11.9164 mL 23.8328 mL
5 mM 0.4767 mL 2.3833 mL 4.7666 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3833 mL 11.9164 mL 23.8328 mL 59.5820 mL
5 mM 0.4767 mL 2.3833 mL 4.7666 mL 11.9164 mL
10 mM 0.2383 mL 1.1916 mL 2.3833 mL 5.9582 mL
15 mM 0.1589 mL 0.7944 mL 1.5889 mL 3.9721 mL
20 mM 0.1192 mL 0.5958 mL 1.1916 mL 2.9791 mL
25 mM 0.0953 mL 0.4767 mL 0.9533 mL 2.3833 mL
30 mM 0.0794 mL 0.3972 mL 0.7944 mL 1.9861 mL
40 mM 0.0596 mL 0.2979 mL 0.5958 mL 1.4895 mL
50 mM 0.0477 mL 0.2383 mL 0.4767 mL 1.1916 mL
60 mM 0.0397 mL 0.1986 mL 0.3972 mL 0.9930 mL
80 mM 0.0298 mL 0.1490 mL 0.2979 mL 0.7448 mL
100 mM 0.0238 mL 0.1192 mL 0.2383 mL 0.5958 mL
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Spironolactone-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Spironolactone-d3SC9420-d3Mineralocorticoid ReceptorAndrogen ReceptorAutophagyInhibitorinhibitorinhibit

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