2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK JAK/STAT Signaling PI3K/Akt/mTOR
  3. HSP EGFR CDK Akt
  4. SST0116CL1

SST0116CL1 is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 has antiproliferative activity and inhibits tumor growth.

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SST0116CL1 Chemical Structure

SST0116CL1 Chemical Structure

CAS No. : 1799802-29-1

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SST0116CL1 Related Antibodies

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Description

SST0116CL1 is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 has antiproliferative activity and inhibits tumor growth[1].

In Vitro

SST0116CL1 has antiproliferative activity on different tumor cell lines, with IC50s of 0.81 μM (A431), 0.11 μM (NCI-H460), 0.81 μM (A2780), 0.40 μM (MV4;11), 0.23 μM (GTL-16), 0.62 μM (BT474), 0.34 μM (HT-1080)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SST0116CL1 Related Antibodies
Molecular Weight

482.96

Formula

C22H31ClN4O6
CAS No.
SMILES

O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SST0116CL1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SST0116CL11799802-29-1HSPEGFRCDKAktHeat shock proteinsEpidermal growth factor receptorErbB-1HER1Cyclin dependent kinasePKBProtein kinase BInhibitorinhibitorinhibit

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