2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. SSTR5 antagonist 2 TFA

SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM).

For research use only. We do not sell to patients.

SSTR5 antagonist 2 TFA Chemical Structure

SSTR5 antagonist 2 TFA Chemical Structure

CAS No. : 1254733-98-6

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SSTR5 antagonist 2 TFA Related Antibodies

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Description

SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM)[1].

IC50 & Target

SSTR5[1].
In Vivo

SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rodent diabetic model without risk of hypoglycemia[1].
Dosage: 10 mg/kg.
Administration: Orally.
Result: Increased both total and active circulating incretin hormone GLP1 levels.
Molecular Weight

660.65

Formula

C34H36F4N2O7
CAS No.
SMILES

FC(C=C1)=CC=C1C2=C(OCC)C=C(CN3CCC4(CN(C5=CC=C(C(O)=O)C=C5)C(C4)=O)CC3)C=C2OCC.OC(C(F)(F)F)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SSTR5 antagonist 2 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SSTR5 antagonist 21254733-98-6Somatostatin ReceptorSSTRsSSTRoralSSTR5type 2 diabetes mellitusT2DMGLP1hypoglycemiaInhibitorinhibitorinhibit

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SSTR5 antagonist 2 TFA
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HY-114191A
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