2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. SSTR5 antagonist 2 hydrochloride

SSTR5 antagonist 2 hydrochloride 

Cat. No.: HY-114191B Purity: 98.85%
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SSTR5 antagonist 2 hydrochloride is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of type 2 diabetes mellitus (T2DM).

For research use only. We do not sell to patients.

SSTR5 antagonist 2 hydrochloride Chemical Structure

SSTR5 antagonist 2 hydrochloride Chemical Structure

CAS No. : 2988224-31-1

Size Price Stock Quantity
5 mg USD 480 In-stock
10 mg USD 750 In-stock
25 mg USD 1500 In-stock
50 mg USD 2400 In-stock
100 mg USD 3900 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of SSTR5 antagonist 2 hydrochloride:

SSTR5 antagonist 2 hydrochloride Related Antibodies

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Description

SSTR5 antagonist 2 hydrochloride is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of type 2 diabetes mellitus (T2DM)[1].

In Vivo

SSTR5 antagonist 2 (compound 10) (10 mg/kg, orally) hydrochloride increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].
SSTR5 antagonist 2 hydrochloride increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

583.09

Formula

C32H36ClFN2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C=C1)=CC=C1C2=C(OCC)C=C(CN3CCC4(CN(C5=CC=C(C(O)=O)C=C5)C(C4)=O)CC3)C=C2OCC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (57.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7150 mL 8.5750 mL 17.1500 mL
5 mM 0.3430 mL 1.7150 mL 3.4300 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7150 mL 8.5750 mL 17.1500 mL 42.8750 mL
5 mM 0.3430 mL 1.7150 mL 3.4300 mL 8.5750 mL
10 mM 0.1715 mL 0.8575 mL 1.7150 mL 4.2875 mL
15 mM 0.1143 mL 0.5717 mL 1.1433 mL 2.8583 mL
20 mM 0.0858 mL 0.4288 mL 0.8575 mL 2.1438 mL
25 mM 0.0686 mL 0.3430 mL 0.6860 mL 1.7150 mL
30 mM 0.0572 mL 0.2858 mL 0.5717 mL 1.4292 mL
40 mM 0.0429 mL 0.2144 mL 0.4288 mL 1.0719 mL
50 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8575 mL
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SSTR5 antagonist 2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SSTR5 antagonist 22988224-31-1Somatostatin ReceptorSSTRsSSTRoralSSTR5type 2 diabetes mellitusT2DMGLP1hypoglycemiaInhibitorinhibitorinhibit

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