MAC glucuronide α-hydroxy lactone-linked SN-38

Cat. No.: HY-128942: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 agent linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC₅₀ values of 99 and 105 ng/mL, respectively.

For research use only. We do not sell to patients.

MAC glucuronide α-hydroxy lactone-linked SN-38 Chemical Structure

CAS No. : 2246380-70-9

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1 mg		Ask For Quote & Lead Time
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time
25 mg		Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Camptothecins

Molecular Weight

1091.06

Formula

C₅₀H₅₄N₆O₂₀S

CAS No.

2246380-70-9

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C([C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(COC(N(CO[C@](C3=C(CO4)C(N5CC6=C(CC)C7=CC(O)=CC=C7N=C6C5=C3)=O)(CC)C4=O)CCS(=O)(C)=O)=O)C=C2NC(CN(C)C(CCN8C(C=CC8=O)=O)=O)=O)O1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (45.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9165 mL	4.5827 mL	9.1654 mL
5 mM	0.1833 mL	0.9165 mL	1.8331 mL
10 mM	0.0917 mL	0.4583 mL	0.9165 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.89%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (257 KB) HNMR (341 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9165 mL	4.5827 mL	9.1654 mL	22.9135 mL
	5 mM	0.1833 mL	0.9165 mL	1.8331 mL	4.5827 mL
	10 mM	0.0917 mL	0.4583 mL	0.9165 mL	2.2913 mL
	15 mM	0.0611 mL	0.3055 mL	0.6110 mL	1.5276 mL
	20 mM	0.0458 mL	0.2291 mL	0.4583 mL	1.1457 mL
	25 mM	0.0367 mL	0.1833 mL	0.3666 mL	0.9165 mL
	30 mM	0.0306 mL	0.1528 mL	0.3055 mL	0.7638 mL
	40 mM	0.0229 mL	0.1146 mL	0.2291 mL	0.5728 mL