2. Stem Cell/Wnt TGF-beta/Smad
  3. PKA
  4. STAD 2

STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism.

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Custom Peptide Synthesis

STAD 2 Chemical Structure

STAD 2 Chemical Structure

CAS No. : 1542100-77-5

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10 mg USD 1025 In-stock
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Based on 1 publication(s) in Google Scholar

STAD 2 Related Antibodies

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Description

STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism[1][2].

IC50 & Target

PKA-RII[1]
Molecular Weight

2096.68

Formula

C102H182N24O22
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{PEG3}-Lys-Lys-Leu-Ala-Lys-Phe-Leu-Val-Ser-{Aaa}-Ala-Leu-Lys-{Aaa}-Ala-Leu-Lys (Covalent bridge:Aaa10-Aaa14)
Sequence Shortening

{PEG3}-KKLAKFLVS{Aaa}ALK{Aaa}ALK (Covalent bridge:Aaa10-Aaa14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (47.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4769 mL 2.3847 mL 4.7694 mL
5 mM 0.0954 mL 0.4769 mL 0.9539 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4769 mL 2.3847 mL 4.7694 mL 11.9236 mL
5 mM 0.0954 mL 0.4769 mL 0.9539 mL 2.3847 mL
10 mM 0.0477 mL 0.2385 mL 0.4769 mL 1.1924 mL
15 mM 0.0318 mL 0.1590 mL 0.3180 mL 0.7949 mL
20 mM 0.0238 mL 0.1192 mL 0.2385 mL 0.5962 mL
25 mM 0.0191 mL 0.0954 mL 0.1908 mL 0.4769 mL
30 mM 0.0159 mL 0.0795 mL 0.1590 mL 0.3975 mL
40 mM 0.0119 mL 0.0596 mL 0.1192 mL 0.2981 mL
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STAD 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAD 21542100-77-5STAD2STAD-2PKAProtein kinase APKA-RIIAKAPantimalariaInhibitorinhibitorinhibit

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